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Cell therapy for a rare disease- hairy cell leukemia variant.
|
Hairy cell leukemia variant (HCL-v) is a rare malignancy of clonal mature B-cells that follows a chronic disease course. HCL-v patients are often resistant to purine nucleoside analogs, which are the first-line therapy. To address the shortcomings of current therapy for HCL-v, we investigated the activity of a BAFF ligand-based CAR-T cell which binds to all three BAFF receptors, BAFF-receptor, TACI, and BCMA. Here, we demonstrate that HCLv patient-derived cells highly express all three BAFF receptors and that BAFF CAR-T cells induce significant cytotoxicity in vitro against both cell lines and HCL-v patient cells. This cytotoxicity corresponds with significant CAR-T cell activation, degranulation, and release of pro-inflammatory cytokines after co-incubation with HCLv cells. Furthermore, we successfully generated BAFF CAR-T cells directly from an HCLv patient and observed direct autologous killing against patient tumor cells in vitro. These HCLv patient-derived CAR-T cells were also effective in killing the Hair-M cell line and tumor cells derived from a different HCLv patient. Lastly, we also developed two mouse xenograft models for HCL, a subcutaneous Bonna-12 model and intravenous Hair-M xenograft model. We observed decreases in tumor burden and prolonged overall survival without significant toxicity. In conclusion, here we show that BAFF CAR-T cells exert anti-tumor effects in vitro and in vivo against multiple cell lines and patient-derived HCL-v samples and may be a successful therapeutic strategy for HCLv patients.
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] | 2024-11-28 | 24 |
39604816
|
[
"HCLv cells",
"multiple cell lines",
"patient tumor cells",
"Hairy cell leukemia variant",
"HCLv patients",
"BAFF CAR-T cells",
"HCLv patient-derived cells",
"HCL-v patient cells",
"significant CAR-T cell activation",
"HCL",
"pro-inflammatory cytokines",
"anti-tumor effects",
"clonal mature B-cells",
"both cell lines",
"BAFF",
"tumor burden",
"the Hair-M cell line and tumor cells",
"significant cytotoxicity",
"These HCLv patient-derived CAR-T cells",
"direct autologous killing",
"significant toxicity",
"current therapy",
"HCL-v patients",
"patient-derived HCL-v samples",
"a different HCLv patient",
"overall survival",
"intravenous Hair-M xenograft model",
"a BAFF ligand-based CAR-T cell",
"nucleoside analogs",
"HCL-v"
] |
[
"BAFF",
"CAR-T cells",
"HCL",
"cytotoxicity",
"leukemia"
] | 0 |
10.1080/2162402X.2024.2432062
10.1016/j.leukres.2012.11.021
10.1016/j.ctrv.2010.05.003
10.2147/OTT.S242247
10.1002/ccr3.2176
10.1186/s13023-020-1325-9
10.1182/blood.V76.1.157.157
10.1182/blood.2020009688
10.1056/NEJMoa1709866
10.1038/s41586-022-05140-y
10.1186/s13045-021-01170-7
10.1186/s13045-022-01308-1
10.3390/biomedicines11102693
10.1038/nrclinonc.2017.128
10.1038/nrclinonc.2013.46
10.3389/fimmu.2022.1034707
10.1158/2159-8290.CD-15-1020
10.1182/blood-2015-08-665547
10.1111/bjh.13562
10.1038/s41467-021-27853-w
10.3389/fimmu.2018.02285
10.1016/j.critrevonc.2014.02.004
10.1080/2162402X.2021.1893501
10.1111/j.1365-2567.2006.02377.x
|
[
"Fritz",
"Wong",
"Rock",
"Burack",
"Radhakrishnan",
"Parameswaran"
] |
[
"Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.",
"Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.",
"Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.",
"Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.",
"Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.",
"Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.\nDivision of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.\nPediatric Hematology and Oncology, The Angie Fowler Adolescent & Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.\nThe Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA."
] |
[
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[] | 6.866675 | 5.914594 |
39604772
| 201 |
A 17-Year Experience of a Large Dedicated Fellowship in Blood and Marrow Transplantation and Cellular Therapy: A Blueprint for Modern Day Training Program.
|
The field of allogeneic blood and marrow transplantation-cellular therapy (BMT-CT) has evolved through incremental advances. Engineered donor grafts, gene editing and chimeric antigen receptor T-cells are all standard clinical practice. Consequently, the scientific knowledge and complexity of clinical skills needed for next generation of BMT-CT physicians have increased. We report a 17-year experience of arguably the largest 12-month BMT-CT clinical fellowship program in the USA. Seventy-three (73) trainees were accepted and 2 cohorts that reflected different time periods (2007-1016 and 2017-2024, inclusive) and different core training curriculum were compared. The cohorts were equivalent in terms of demographics; notably, most (70%) had graduated from international medical schools and trained in the US on a non-immigrant J1 visa. In 2015, we introduced a structured mentoring program to address the desire of trainees for experience with scholarly activities. There was a high rate of successful academic careers with a trend toward a higher likelihood of academic retention following structured mentoring (70% vs 89%). In this report, we included our detailed core curriculum and highlight potential future changes as a blueprint for modern day programs to ensure that graduate "transplant docs" can continue to contribute at the highest academic level.
|
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] | 2024-11-28 | 10 |
39604772
|
[
"different core training curriculum",
"modern day programs",
"clinical skills",
"standard clinical practice",
"successful academic careers",
"academic retention",
"different time periods",
"international medical schools",
"potential future changes",
"structured mentoring",
"gene editing",
"Engineered donor grafts",
"next generation",
"experience",
"allogeneic blood",
"BMT-CT physicians",
"trainees",
"BMT-CT",
"a structured mentoring program",
"a non-immigrant J1 visa",
"scholarly activities",
"our detailed core curriculum",
"incremental advances",
"antigen receptor T-cells",
"the highest academic level",
"marrow transplantation-cellular therapy",
"US",
"the largest 12-month BMT-CT clinical fellowship program",
"demographics",
"complexity"
] |
[
"Blood and marrow transplantation",
"Cell therapy",
"Fellowship",
"Training"
] | 0 |
10.1007/s13187-024-02545-3
10.1182/blood-2019-125232
10.1016/S1083-8791(01)70019-5
10.1016/j.bbmt.2012.04.007
10.1016/j.jtct.2021.12.011
10.1038/s42255-022-00537-5
10.1200/EDBK_200983
10.1007/s13187-023-02375-9
10.1016/j.jtct.2023.03.011
10.1016/j.jtct.2024.04.005
10.1200/JCO.2011.35.8663
10.1182/bloodadvances.2024013218
|
[
"Bharadwaj",
"Lowsky",
"Mikkilineni",
"Smith",
"Weng"
] |
[
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA94304, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA94304, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA94304, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA94304, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA94304, USA. wkweng@stanford.edu."
] |
[
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] |
[] | 7.0323 | 4.14585 |
39604730
| 202 |
Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers.
|
Interleukin-15 (IL-15) promotes the survival of T lymphocytes and enhances the antitumour properties of chimeric antigen receptor (CAR) T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy
|
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] | 2024-11-28 | 44 |
39604730
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[
"chimeric antigen receptor",
"T",
"CAR",
"preclinical models",
"solid neoplasms",
"CAR T cells",
"limited efficacy",
"IL-15",
"CAR) T cells",
"Interleukin-15",
"the antitumour properties",
"the survival",
"which"
] |
[] | 0 |
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[
"Steffin",
"Ghatwai",
"Montalbano",
"Rathi",
"Courtney",
"Arnett",
"Fleurence",
"Sweidan",
"Wang",
"Zhang",
"Masand",
"Maris",
"Martinez",
"Pogoriler",
"Varadarajan",
"Thakkar",
"Lyon",
"Lapteva",
"Zhuyong",
"Patel",
"Lopez-Terrada",
"Ramos",
"Lulla",
"Armaghany",
"Grilley",
"Gottschalk",
"Dotti",
"Metelitsa",
"Heslop",
"Brenner",
"Sumazin",
"Heczey"
] |
[
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.",
"Center for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.\nDepartment of Immunology and Microbiology, Baylor College of Medicine, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Department of Radiology, Baylor College of Medicine, Houston, TX, USA.",
"Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
"Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
"Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
"William A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.\nPathology and Immunology Graduate Program, Baylor College of Medicine, Houston, TX, USA.\nDepartment of Pathology, Baylor College of Medicine, Houston, TX, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Department of Pathology, Baylor College of Medicine, Houston, TX, USA.",
"Department of Pathology, Baylor College of Medicine, Houston, TX, USA.",
"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.",
"Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. heczey@bcm.edu.\nCenter for Advanced Innate Cell Therapy, Baylor College of Medicine, Houston, TX, USA. heczey@bcm.edu.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. heczey@bcm.edu.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA. heczey@bcm.edu.\nTexas Children's Hospital Liver Tumor Program, Houston, TX, USA. heczey@bcm.edu."
] |
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[] | 7.713646 | 5.42682 |
39603960
| 203 |
Advances in cell therapy: progress and challenges in hematological and solid tumors.
|
Cell-based therapies harness the endogenous ability of the immune system to fight cancer and have shown promising results in the treatment of hematological malignancies. However, their clinical application beyond B cell malignancies is hampered by numerous hurdles, ranging from relapsed disease to a hostile tumor microenvironment (TME). Recent advances in cell engineering and TME modulation may expand the applicability of these therapies to a wider range of cancers, creating new treatment possibilities. Breakthroughs in advanced gene editing and sophisticated cell engineering, have also provided promising solutions to longstanding challenges. In this review, we examine the challenges and future directions of the most prominent cell-based therapies, including chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes (TILs), and natural killer (NK) cells, and emerging modalities. We provide a comprehensive analysis of emerging cell types and combination strategies translated into clinical trials, offering insights into the next generation of cell-based cancer treatments.
|
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] | 2024-11-28 | 1 |
39603960
|
[
"cell engineering",
"sophisticated cell engineering",
"emerging cell types",
"CAR)-T cells",
"B cell malignancies",
"cell-based cancer treatments",
"Cell-based therapies",
"promising results",
"new treatment possibilities",
"promising solutions",
"cancer",
"cancers",
"clinical trials",
"advanced gene editing",
"chimeric antigen receptor",
"TME modulation",
"hematological malignancies",
"longstanding challenges",
"future directions",
"relapsed disease",
"numerous hurdles",
"emerging modalities",
"combination strategies",
"natural killer (NK) cells",
"TME",
"the most prominent cell-based therapies",
"Recent advances",
"TILs",
"insights",
"tumor-infiltrating lymphocytes"
] |
[
"CAR-T cells",
"antitumor immune response",
"cell therapy",
"tumor-infiltrating lymphocytes"
] | 0 |
10.1016/j.tips.2024.10.016
|
[
"D'Avanzo",
"Blaeschke",
"Lysandrou",
"Ingelfinger",
"Zeiser"
] |
[
"Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.",
"German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Heidelberg University Hospital, Heidelberg, Germany.",
"Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.",
"Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.",
"Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: robert.zeiser@uniklinik-freiburg.de."
] |
[
"39603960"
] |
[] | 10.287763 | 4.028097 |
39601444
| 204 |
Human T cells engineered with an HLA-A2-restricted murine T-cell receptor targeting glypican 3 effectively control human hepatocellular carcinoma in mice.
|
Glypican-3 (GPC3) is a promising target for T-cell therapy in HCC. While chimeric antigen receptor (CAR) T cells targeting GPC3 have demonstrated therapeutic efficacy, their effectiveness is limited by challenges such as low persistence and shedding of surface GPC3. Natural T-cell receptors (TCRs) may serve as an alternative, though identifying GPC3-specific TCRs within the endogenous repertoire is difficult.
We immunized human leucocyte antigen-A2 (HLA-A2) transgenic mice with an adenovirus expressing human GPC3, identifying a panel of TCRs that recognize the GPC3(522-530) epitope. We cloned 3 murine GPC3-TCRs (TCR-A, TCR-B, and TCR-C) and engineered primary human T cells (TCR-T). TCR-T cells effectively recognized GPC3 + HLA-A2 + human HCC cells, with recognition diminished by GPC3 silencing and HLA-A2 blockade. TCR-B-T and TCR-C-T cells showed the highest reactivity, with TCR-B-T cells exhibiting superior effector functions, proliferative capacity, and therapeutic efficacy in xenograft HCC models. Notable, TCR-B-T cells outperformed second-generation 41BB GPC3-specific CAR-T cells, attributed to lower exhaustion, enhanced proliferation, greater effector function, and improved resilience. Furthermore, mixed dosing of CAR-T and TCR-B-T cells was significantly more effective than staggered dosing of the same cell type, suggesting potential synergistic effects.
Transgenic TCRs join forces with CARs, expanding the arsenal of GPC3-targeting receptors for HCC T-cell therapy.
|
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] | 2024-11-27 | 1 |
39601444
|
[
"primary human T cells",
"human GPC3",
"GPC3",
"TCR-T cells",
"CAR) T cells",
"T-cell therapy",
"greater effector function",
"superior effector functions",
"HCC T-cell therapy",
"Natural T-cell receptors",
"therapeutic efficacy",
"Transgenic TCRs",
"TCRs",
"TCR-B-T cells",
"GPC3-specific TCRs",
"xenograft HCC models",
"low persistence",
"the same cell type",
"GPC3-targeting receptors",
"lower exhaustion",
"chimeric antigen receptor",
"GPC3 + HLA-A2 + human HCC cells",
"HCC",
"CARs",
"second-generation 41BB GPC3-specific CAR-T cells",
"potential synergistic effects",
"CAR-T and TCR-B-T cells",
"enhanced proliferation",
"GPC3-TCRs",
"proliferative capacity"
] |
[] | 0 |
10.1097/HEP.0000000000001175
|
[
"Vercher",
"Covo-Vergara",
"Conde",
"Hernández-Rueda",
"Elizalde",
"Mancheño",
"Glez-Vaz",
"Tamayo-Uria",
"García-García",
"Ferrer-Roig",
"Marañón-Lopez",
"Repáraz",
"Ruiz",
"López-Díaz de Cerio",
"Inogés",
"Iñarrairaegui",
"Lasarte",
"Sangro",
"Sarobe",
"Hervas-Stubbs"
] |
[
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.\nSchool of Medicine, Autonomous University of Guadalajara, Jalisco, Mexico.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.\nCell Therapy Area, Clínica Universidad de Navarra, Pamplona, Spain.",
"Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.\nCell Therapy Area, Clínica Universidad de Navarra, Pamplona, Spain.",
"Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.\nLiver Unit, Clínica Universidad de Navarra, Pamplona, Spain.\nCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.",
"Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.\nLiver Unit, Clínica Universidad de Navarra, Pamplona, Spain.\nCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.\nCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Pamplona, Spain.",
"Immunology and Immunotherapy Program,Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.\nInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.\nCancer Clinic University of Navarra (CCUN), Pamplona, Spain.\nCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Pamplona, Spain."
] |
[
"39601444"
] |
[] | 8.99152 | 5.833854 |
39600090
| 205 |
Managing allorejection in off-the-shelf CAR-engineered cell therapies.
|
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has revolutionized the treatment of various diseases, including cancers and autoimmune disorders. However, all US Food and Drug Administration (FDA)-approved CAR-T cell therapies are autologous, and their widespread clinical application is limited by several challenges, such as complex individualized manufacturing, high costs, and the need for patient-specific selection. Allogeneic off-the-shelf CAR-engineered cell therapy offers promising potential due to its immediate availability, consistent quality, potency, and scalability in manufacturing. Nonetheless, significant challenges, including the risks of graft-versus-host disease (GvHD) and host-cell-mediated allorejection, must be addressed. Strategies such as knocking out endogenous T cell receptors (TCRs) or using alternative therapeutic cells with low GvHD risk have shown promise in clinical trials aimed at reducing GvHD. However, mitigating allorejection remains critical for ensuring the long-term sustainability and efficacy of off-the-shelf cell products. In this review, we discuss the immunological basis of allorejection in CAR-engineered therapies and explore various strategies to overcome this challenge. We also highlight key insights from recent clinical trials, particularly related to the sustainability and immunogenicity of allogeneic CAR-engineered cell products, and address manufacturing considerations aimed at minimizing allorejection and optimizing the efficacy of this emerging therapeutic approach.
|
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] | 2024-11-27 | 1 |
39600090
|
[
"alternative therapeutic cells",
"recent clinical trials",
"clinical trials",
"FDA)-approved CAR-T cell therapies",
"low GvHD risk",
"complex individualized manufacturing",
"allogeneic CAR-engineered cell products",
"address manufacturing considerations",
"various diseases",
"allorejection",
"endogenous T cell receptors",
"several challenges",
"various strategies",
"manufacturing",
"Chimeric antigen receptor",
"significant challenges",
"high costs",
"consistent quality",
"GvHD",
"CAR-engineered therapies",
"promising potential",
"efficacy",
"host-cell-mediated allorejection",
"key insights",
"host",
"autoimmune disorders",
"Strategies",
"their widespread clinical application",
"potency",
"TCRs"
] |
[
"B2M",
"CAR-T cells",
"CIITA",
"HLA",
"NK cells",
"allogeneic cell therapy",
"allorejection",
"beta-2-microglobulin",
"chimeric antigen receptor-engineered T cells",
"class II major histocompatibility complex transactivator",
"genetic engineering",
"human leukocyte antigen",
"natural killer cells",
"off-the-shelf cell therapy"
] | 0 |
10.1016/j.ymthe.2024.11.035
|
[
"Li",
"Fang",
"Niu",
"Chen",
"Lyu",
"Yang"
] |
[
"Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: charlie.li@ucla.edu.",
"Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.",
"Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.",
"Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.",
"Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.",
"Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: liliyang@g.ucla.edu."
] |
[
"39600090"
] |
[] | 8.289518 | 3.264342 |
39599106
| 206 |
A Microfluidic-Based Sensing Platform for Rapid Quality Control on Target Cells from Bioreactors.
|
We investigated the design and characterization of a Lab-On-a-Chip (LoC) cell detection system primarily designed to support immunotherapy in cancer treatment. Immunotherapy uses Chimeric Antigen Receptors (CARs) and T Cell Receptors (TCRs) to fight cancer, engineering the response of the immune system. In recent years, it has emerged as a promising strategy for personalized cancer treatment. However, it requires bioreactor-based cell culture expansion and manual quality control (QC) of the modified cells, which is time-consuming, labour-intensive, and prone to errors. The miniaturized LoC device for automated QC demonstrated here is simple, has a low cost, and is reliable. Its final target is to become one of the building blocks of an LoC for immunotherapy, which would take the place of present labs and manual procedures to the benefit of throughput and affordability. The core of the system is a commercial, on-chip-integrated capacitive sensor managed by a microcontroller capable of sensing cells as accurately measured charge variations. The hardware is based on standardized components, which makes it suitable for mass manufacturing. Moreover, unlike in other cell detection solutions, no external AC source is required. The device has been characterized with a cell line model selectively labelled with gold nanoparticles to simulate its future use in bioreactors in which labelling can apply to successfully engineered CAR-T-cells. Experiments were run both in the air-free drop with no microfluidics-and in the channel, where the fluid volume was considerably lower than in the drop. The device showed good sensitivity even with a low number of cells-around 120, compared with the 10
|
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] | 2024-11-27 | 25 |
39599106
|
[
"sensing cells",
"cells",
"other cell detection solutions",
"personalized cancer treatment",
"manual quality control",
"cancer treatment",
"bioreactor-based cell culture expansion",
"automated QC",
"manual procedures",
"Chimeric Antigen Receptors",
"present labs",
"T Cell Receptors",
"cancer",
"Immunotherapy",
"immunotherapy",
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"standardized components",
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"gold nanoparticles",
"the modified cells",
"good sensitivity",
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"mass manufacturing",
"recent years",
"TCRs",
"labelling",
"successfully engineered CAR-T-cells",
"CARs",
"characterization"
] |
[
"CAR-T quality control",
"capacitive sensor",
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] | 0 |
10.3390/s24227329
10.1038/nrclinonc.2016.25
10.1038/nrclinonc.2014.111
10.1016/j.diff.2022.05.002
10.4161/onci.21206
10.1016/j.biotechadv.2021.107735
10.1007/978-1-0716-0146-4_10
10.1016/j.eng.2018.12.003
10.1016/j.heliyon.2023.e16229
10.1007/978-1-0716-0146-4_14
10.3390/cells10113208
10.3389/fimmu.2024.1335932
10.1016/j.mex.2022.101759
10.1016/j.mee.2016.07.006
10.3390/mi12020104
10.1186/s12967-015-0519-8
10.1002/biot.201800239
10.1039/D3AN00958K
10.1016/j.cca.2022.09.014
10.1088/1361-665X/aa6490
10.1016/j.talanta.2023.125280
10.1039/D0LC00840K
10.1002/smtd.202301195
10.1021/acs.analchem.0c02556
10.1109/TBCAS.2015.2504984
10.1038/s41598-022-18005-1
10.1109/TBCAS.2016.2593639
10.3390/ijms21113906
|
[
"Foscarini",
"Romano",
"Garzarelli",
"Turco",
"Bramanti",
"Tarantini",
"Ferrara",
"Visconti",
"Gigli",
"Chiriacò"
] |
[
"CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.\nDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.",
"Department of Innovation Engineering, University of Salento, Via per Monteroni, Building 'O', 73100 Lecce, Italy.",
"CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.\nDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.\nDepartment of Mathematics and Physics, E. De Giorgi, University of Salento, Via per Arnesano, 73100 Lecce, Italy.",
"CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.",
"Department of Innovation Engineering, University of Salento, Via per Monteroni, Building 'O', 73100 Lecce, Italy.\nSTMicroelectronics srl, c/o Campus Ecotekne, Via per Monteroni, 165, 73100 Lecce, Italy.",
"CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.\nDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.",
"CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.",
"Department of Innovation Engineering, University of Salento, Via per Monteroni, Building 'O', 73100 Lecce, Italy.",
"CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.\nDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.",
"CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy."
] |
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[] | 8.786498 | 3.685874 |
39596267
| 207 |
Significant Advancements and Evolutions in Chimeric Antigen Receptor Design.
|
Recent times have witnessed remarkable progress in cancer immunotherapy, drastically changing the cancer treatment landscape. Among the various immunotherapeutic approaches, adoptive cell therapy (ACT), particularly chimeric antigen receptor (CAR) T cell therapy, has emerged as a promising strategy to tackle cancer. CAR-T cells are genetically engineered T cells with synthetic receptors capable of recognising and targeting tumour-specific or tumour-associated antigens. By leveraging the intrinsic cytotoxicity of T cells and enhancing their tumour-targeting specificity, CAR-T cell therapy holds immense potential in achieving long-term remission for cancer patients. However, challenges such as antigen escape and cytokine release syndrome underscore the need for the continued optimisation and refinement of CAR-T cell therapy. Here, we report on the challenges of CAR-T cell therapies and on the efforts focused on innovative CAR design, on diverse therapeutic strategies, and on future directions for this emerging and fast-growing field. The review highlights the significant advances and changes in CAR-T cell therapy, focusing on the design and function of CAR constructs, systematically categorising the different CARs based on their structures and concepts to guide researchers interested in ACT through an ever-changing and complex scenario. UNIVERSAL CARs, engineered to recognise multiple tumour antigens simultaneously, DUAL CARs, and SUPRA CARs are some of the most advanced instances. Non-molecular variant categories including CARs capable of secreting enzymes, such as catalase to reduce oxidative stress in situ, and heparanase to promote infiltration by degrading the extracellular matrix, are also explained. Additionally, we report on CARs influenced or activated by external stimuli like light, heat, oxygen, or nanomaterials. Those strategies and improved CAR constructs in combination with further genetic engineering through CRISPR/Cas9- and TALEN-based approaches for genome editing will pave the way for successful clinical applications that today are just starting to scratch the surface. The frontier lies in bringing those approaches into clinical assessment, aiming for more regulated, safer, and effective CAR-T therapies for cancer patients.
|
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39596267
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[
"T cells",
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"improved CAR constructs",
"UNIVERSAL CARs",
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"CAR-T cells",
"cancer immunotherapy",
"cancer patients",
"successful clinical applications",
"cancer",
"diverse therapeutic strategies",
"clinical assessment",
"Non-molecular variant categories",
"further genetic engineering",
"the different CARs",
"remarkable progress",
"external stimuli",
"oxidative stress",
"synthetic receptors",
"genome editing",
"future directions",
"ACT"
] |
[
"ATMP",
"CAR-T cells",
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10.3390/ijms252212201
10.1371/journal.pone.0184360
10.1038/nrclinonc.2015.222
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10.1155/2019/4508794
10.1038/nm.3161
10.1002/cpt.985
10.3390/ijms221910828
10.3389/fimmu.2018.01717
10.1172/JCI46110
10.1038/s41568-020-00323-z
10.1056/NEJMoa1707447
10.1002/hon.2591
10.1038/s41434-021-00254-w
10.1182/blood.2021010858
10.3390/ijms21218000
10.1007/s00277-023-05444-7
10.3389/fimmu.2022.991092
10.1186/s13045-018-0681-6
10.1136/bmj-2021-068956
10.1182/blood-2018-99-115465
10.1038/mt.2011.1
10.1038/s41423-021-00655-2
10.1038/s41573-021-00189-2
10.3389/fimmu.2020.01109
10.4049/jimmunol.1700433
10.1038/nri.2017.49
10.1038/s41571-018-0007-1
10.1016/j.coi.2015.01.011
10.1038/nri.2017.145
10.1186/s13046-022-02327-z
10.1038/s41408-021-00459-7
10.3389/fonc.2019.00146
10.1007/s12094-020-02490-9
10.1038/s41591-018-0326-x
10.1155/2017/7513687
10.1016/j.ymthe.2018.09.009
10.3389/fonc.2022.832765
10.3109/08830185.2015.1018419
10.1038/leu.2010.75
10.1080/21645515.2022.2114254
10.1038/s41586-023-05778-2
10.1186/s13045-018-0646-9
10.1186/s13045-019-0705-x
10.3324/haematol.2018.208751
10.1158/2326-6066.CIR-15-0231
10.1172/JCI83416
10.1073/pnas.1524155113
10.1038/nm.4441
10.1158/1078-0432.CCR-20-3863
10.1182/blood-2013-03-478255
10.1182/blood-2013-09-529537
10.3389/fimmu.2021.744823
10.1097/01.cji.0000161397.96582.59
10.1007/s00262-019-02399-5
10.1016/j.omto.2020.04.009
10.1016/j.cell.2018.03.038
10.1186/s13045-018-0677-2
10.1158/1078-0432.CCR-12-1449
10.1016/j.cell.2016.01.012
10.1126/science.abc6270
10.1126/scitranslmed.abd8836
10.1126/scitranslmed.abe7378
10.1016/j.celrep.2017.11.063
10.1158/2326-6066.CIR-13-0099-T
10.1073/pnas.092562399
10.1038/s41598-017-11126-y
10.1016/j.canlet.2011.10.027
10.1186/1476-4598-13-219
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10.3389/fimmu.2020.01965
10.1038/nrclinonc.2017.148
10.1007/s12015-019-09901-7
10.18632/oncotarget.23556
10.1158/2326-6066.CIR-13-0170
10.1158/0008-5472.CAN-13-1365
10.1038/bcj.2016.61
10.3390/ijms21197222
10.1021/jacs.5b00106
10.1016/j.jcyt.2015.10.014
10.1172/JCI87366
10.1186/s13045-020-00856-8
10.1038/mt.2013.262
10.1038/nbt.2459
10.1182/bloodadvances.2022008762
10.1007/s10875-012-9689-9
10.1038/mtna.2013.32
10.2147/OTT.S190336
10.1186/s40425-017-0246-1
10.1038/s41375-018-0212-z
10.1016/j.cell.2009.03.045
10.1038/nsmb1227
10.1016/j.devcel.2015.05.004
10.1016/j.cell.2016.01.011
10.1016/j.ccell.2019.02.003
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10.3389/fimmu.2022.880108
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10.1038/sj.cgt.7700100
10.3390/cancers12082087
10.3109/10715761003667554
10.1186/s13045-020-0843-1
10.4049/jimmunol.0900092
10.4049/jimmunol.168.2.689
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10.3389/fonc.2019.01143
10.1186/s13045-018-0600-x
10.1158/0008-5472.CAN-04-0465
10.1016/S1471-4906(03)00132-7
10.1038/s41590-020-0666-9
10.1038/s41586-018-0622-0
10.3389/fonc.2019.00322
10.2147/BTT.S291768
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10.1038/sj.gene.6364246
10.3389/fimmu.2018.00847
10.1038/cddis.2017.67
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10.1097/CJI.0000000000000260
10.1371/journal.pone.0077769
10.1136/jitc-2021-003837
10.4161/2162402X.2014.994446
10.1038/s41598-017-10940-8
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10.1182/blood-2009-03-209650
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10.1038/ncomms8458
10.1182/blood.2022018330
10.1182/blood-2020-142228
10.1016/j.scib.2020.12.027
10.1038/s41392-021-00544-0
10.1038/nri1918
10.1189/jlb.0507315
10.2174/138161207781039742
10.1002/jcp.1041300113
10.1038/sj.onc.1209425
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10.1146/annurev-immunol-032713-120257
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10.2174/1874471008666150313114005
10.1038/nature22395
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10.1038/srep20070
10.1172/JCI83092
10.3389/fmolb.2021.745286
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10.1146/annurev-pathol-012513-104720
10.1038/s41467-017-02375-6
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10.1016/j.canlet.2018.03.010
10.1016/j.humimm.2018.09.007
10.1038/nature21405
10.1016/j.beha.2019.101097
10.1126/science.aab4077
10.1016/j.bbrc.2018.10.151
10.1158/2326-6066.CIR-16-0043
10.1016/j.ymthe.2020.06.004
10.1126/science.aba1786
10.1021/acsmedchemlett.9b00597
10.1073/pnas.2106612118
10.3389/fphar.2014.00254
10.1182/blood-2004-11-4564
10.1056/NEJMoa1106152
10.1126/scitranslmed.aau5907
10.1182/bloodadvances.2018028720
10.1038/s41467-020-20696-x
10.1111/pcn.12516
10.1038/nmeth.f.324
10.1111/boc.201200056
10.1038/nmeth.1524
10.1126/sciadv.aay9209
10.1016/j.chembiol.2020.10.004
10.1073/pnas.2019285118
10.1038/s41589-021-00792-9
10.1126/science.aaq1144
10.1038/nbt.3415
10.1016/j.cell.2015.06.058
10.1038/s41565-021-00982-5
10.1146/annurev-chembioeng-060817-084034
10.1073/pnas.1714900115
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10.1016/j.scib.2023.11.055
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10.1158/0008-5472.CAN-23-1038
10.1002/adma.202310168
10.3390/vaccines11030658
10.3390/molecules25092193
10.1016/j.ccell.2019.02.006
10.1016/j.celrep.2018.04.051
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[
"Gaimari",
"De Lucia",
"Nicolini",
"Mazzotti",
"Maltoni",
"Rughi",
"Zurlo",
"Marchesini",
"Juan",
"Parras",
"Cerchione",
"Martinelli",
"Bravaccini",
"Tettamanti",
"Pasetto",
"Pasini",
"Magnoni",
"Gazzola",
"Borges de Souza",
"Mazza"
] |
[
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Centro Trial Oncoematologico, Department of \"Onco-Ematologia e Terapia Cellulare e Genica Bambino\" Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Department of Immunology, Centre de Diagnòstic Biomèdic, Hospital Clínic of Barcelona, 08036 Barcelona, Spain.",
"Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Faculty of Medicine and Surgery, \"Kore\" University of Enna, 94100 Enna, Italy.",
"Centro Ricerca Tettamanti, Clinica Pediatrica, Università Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, 20900 Monza, Italy.",
"Oslo University Hospital, 0424 Oslo, Norway.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.\nDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40127 Bologna, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.\nDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40127 Bologna, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy.",
"Scientific Institute for Research, Hospitalization and Healthcare, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", 40121 Meldola, Italy."
] |
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[] | 9.30518 | 3.99571 |
39595996
| 208 |
Folate Receptor Alpha-A Secret Weapon in Ovarian Cancer Treatment?
|
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy worldwide. Due to its nonspecific symptoms and unreliable screening tools, EOC is not diagnosed at an early stage in most cases. Unfortunately, despite achieving initial remission after debulking surgery and platinum-based chemotherapy, most patients experience the recurrence of the disease. The limited therapy approaches have encouraged scientists to search for new detection and therapeutic strategies. In this review, we discuss the role of folate receptor alpha (FRα) in EOC development and its potential application as a biomarker and molecular target in designing new EOC screening and treatment methods. We summarize the mechanisms of the action of various therapeutic strategies based on FRα, including MABs (monoclonal antibodies), ADCs (antibody-drug conjugates), FDCs (folate-drug conjugates), SMDCs (small molecule-drug conjugates), vaccines, and CAR-T (chimeric antigen receptor T) cells, and present the most significant clinical trials of some FRα-based drugs. Furthermore, we discuss the pros and cons of different FR-based therapies, highlighting mirvetuximab soravtansine (MIRV) as the currently most promising EOC-targeting drug.
|
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39595996
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|
[
"Bukowski",
"Rogalska",
"Marczak"
] |
[
"Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland.",
"Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland.",
"Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland."
] |
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[] | 11.144222 | 4.969548 |
39594822
| 209 |
Cellular Therapies for Multiple Myeloma: Engineering Hope.
|
Multiple myeloma (MM) treatment remains challenging due to its relapsed/refractory disease course as well as intra- and inter-patient heterogeneity. Cellular immunotherapies, especially chimeric antigen receptor (CAR)-T cells targeting B cell maturation antigen (BCMA), mark a major breakthrough, achieving long-lasting remissions and instilling hope for a potential cure. While ongoing clinical trials are increasingly driving approved cellular products towards earlier lines of therapy, novel targets as well as advanced approaches employing natural killer (NK) cells or dendritic cell (DC) vaccines are currently under investigation. Treatment resistance, driven by tumor-intrinsic factors such as antigen escape and the intricate dynamics of the tumor microenvironment (TME), along with emerging side effects such as movement and neurocognitive treatment-emergent adverse events (MNTs), are the major limitations of approved cellular therapies. To improve efficacy and overcome resistance, cutting-edge research is exploring strategies to target the microenvironment as well as synergistic combinatorial approaches. Recent advances in CAR-T cell production involve shortened manufacturing protocols and "off-the-shelf" CAR-T cells, aiming at decreasing socioeconomic barriers and thereby increasing patient access to this potential lifesaving therapy. In this review, we provide an extensive overview of the evolving field of cellular therapies for MM, underlining the potential to achieve long-lasting responses.
|
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39594822
|
[
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"CAR)-T cells",
"cellular therapies",
"dendritic cell",
"approved cellular products",
"Treatment resistance",
"Cellular immunotherapies",
"antigen escape",
"inter-patient heterogeneity",
"therapy",
"patient access",
"synergistic combinatorial approaches",
"emerging side effects",
"advanced approaches",
"CAR-T cell production",
"socioeconomic barriers",
"manufacturing protocols",
"novel targets",
"MM",
"earlier lines",
"ongoing clinical trials",
"neurocognitive treatment-emergent adverse events",
"this potential lifesaving therapy",
"Recent advances",
"natural killer (NK) cells",
"especially chimeric antigen receptor",
"strategies",
"movement",
"TME"
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[
"BCMA",
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"CAR-T",
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[
"Vera-Cruz",
"Jornet Culubret",
"Konetzki",
"Alb",
"Friedel",
"Hudecek",
"Einsele",
"Danhof",
"Scheller"
] |
[
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.\nFraunhofer-Institut für Zelltherapie und Immunologie (IZI), Außenstelle Zelluläre Immuntherapie, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.\nMildred Scheel Early Career Center, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.\nInterdisziplinäres Zentrum für Klinische Forschung (IZKF), Universitätsklinikum Würzburg, 97080 Würzburg, Germany."
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Ion channels of T cells (Kv1.3, KCa3.1, and CRAC) participate in the regulation of activation and effector functions via modulation of the Ca
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] | 2024-11-27 | 34 |
39594705
|
[
"effector functions",
"T cells",
"Ion channels",
"Kv1.3",
"activation",
"KCa3.1",
"CRAC",
"modulation",
"the regulation",
"the Ca"
] |
[
"CAR T cells",
"CRAC",
"KCa3.1",
"Kv1.3",
"cancer",
"immunotherapy",
"ion channels"
] | 0 |
10.3390/cancers16223750
10.1016/j.it.2015.06.004
10.1038/s41551-018-0235-9
10.1073/pnas.90.2.720
10.1002/acg2.84
10.1016/j.ymthe.2020.10.022
10.1186/s13287-020-02128-1
10.1126/scitranslmed.3008226
10.1016/j.ymthe.2020.09.015
10.1038/ncomms14644
10.1038/nri3233
10.1016/j.imlet.2003.11.020
10.1073/pnas.90.13.6295
10.1016/j.it.2020.06.012
10.1098/rstb.2013.0106
10.1517/14728220903018957
10.1073/pnas.0605136103
10.1038/onc.2008.271
10.1038/nature19364
10.3390/biomedicines11020626
10.1158/1535-7163.1585.3.12
10.3390/cancers13174301
10.1038/mt.2009.133
10.1158/2159-8290.CD-17-0263
10.1038/307468a0
10.1371/journal.pone.0054267
10.1038/s41408-021-00459-7
10.1074/jbc.M800637200
10.1126/scisignal.aaq1616
10.1111/bjh.19117
10.1073/pnas.97.14.8151
10.1124/mol.112.078006
10.1371/journal.pone.0076740
10.3390/cells12162065
10.1113/JP274964
|
[
"Medyouni",
"Vörös",
"Jusztus",
"Panyi",
"Vereb",
"Szöőr",
"Hajdu"
] |
[
"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.",
"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.",
"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.",
"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.",
"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.\nFaculty of Pharmacy, University of Debrecen, 4032 Debrecen, Hungary.",
"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.",
"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.\nDivision of Dental Biochemistry, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary."
] |
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[] | 33.423004 | 7.409365 |
39594640
| 211 |
Multicellular Cancer-Stroma Spheres (CSS) for In Vitro Assessment of CAR-T Cell-Associated Toxicity.
|
CAR-T therapy has revolutionized the field of oncology, offering a promising treatment option for cancer patients. However, the significant morbidity associated with therapy-related toxicity presents a major challenge to its widespread use. Despite extensive research into the underlying mechanisms of CAR-T therapy-related toxicity, there are still many unknowns. Furthermore, the lack of adequate in vitro models for assessing immunotoxicity and neurotoxicity further complicates the development of safer cellular therapies. Previously in our laboratory, we developed cancer-stroma spheres (CSS) composed of prostate adenocarcinoma PC3 cells and mesenchymal stem cells (MSC). Herein we present evidence that multicellular CSS could serve as a valuable in vitro model for toxicity studies related to CAR-T therapy. CSS containing CD19-overexpressing PC3M cells exhibited increased secretion of CAR-T cell toxicity-associated IL-8, MCP-1, and IP-10 in the presence of anti-CD19 CAR-T cells, compared to spheres derived from single cell types.
|
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] | 2024-11-27 | 56 |
39594640
|
[
"prostate adenocarcinoma PC3 cells",
"mesenchymal stem cells",
"single cell types",
"toxicity studies",
"safer cellular therapies",
"anti-CD19 CAR-T cells",
"multicellular CSS",
"PC3M",
"CAR-T therapy",
"CSS",
"CD19-overexpressing PC3M cells",
"CAR-T therapy-related toxicity",
"CAR-T cell toxicity-associated IL-8",
"therapy-related toxicity",
"cancer patients",
"spheres",
"increased secretion",
"extensive research",
"many unknowns",
"cancer-stroma spheres",
"immunotoxicity",
"neurotoxicity",
"oncology",
"IP-10",
"MCP-1",
"a promising treatment option",
"evidence",
"MSC",
"a valuable in vitro model",
"a major challenge"
] |
[
"CAR-T therapy",
"IL-8",
"IP-10",
"MCP-1",
"cancer-stroma spheres",
"cytokine release syndrome",
"immune effector cell-associated neurotoxicity syndrome",
"mesenchymal stem cell"
] | 0 |
10.3390/cells13221892
10.1126/scitranslmed.3008226
10.1016/S1470-2045(18)30864-7
10.1158/2159-8290.CD-17-1319
10.1182/blood-2019-131077
10.1182/blood-2017-06-793141
10.1056/NEJMoa1709866
10.1056/NEJMoa1707447
10.1056/NEJMoa1804980
10.1038/s41591-018-0041-7
10.1093/intimm/dxad033
10.1016/j.canlet.2013.10.004
10.1158/2159-8290.CD-16-0040
10.1038/s41591-021-01622-0
10.1056/NEJMoa1914347
10.1016/S0140-6736(21)01222-8
10.1016/S0140-6736(20)31366-0
10.1002/hon.3196_LBA4
10.1016/S0140-6736(23)01052-8
10.1056/NEJMoa2213614
10.1200/JCO.22.00842
10.1038/s41392-020-00256-x
10.1084/jem.20190945
10.1126/sciimmunol.aax7969
10.1038/s41409-020-01134-4
10.1158/2159-8290.CD-17-0698
10.1002/ana.25315
10.1038/s41591-018-0036-4
10.3390/ijms23063154
10.1002/cpz1.864
10.1038/s44321-024-00055-9
10.1038/s41467-023-37785-2
10.21037/atm.2019.12.03
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10.1016/j.trecan.2020.10.009
10.1016/j.tranon.2024.101930
10.3390/jpm13111621
10.3390/biomedicines11020626
10.1136/gutjnl-2018-316595
10.1002/pros.22640
10.1016/j.cyto.2021.155479
10.1016/j.immuni.2009.09.002
10.1016/j.bbmt.2018.12.686
10.1038/cmi.2015.50
10.1007/s00262-003-0445-0
10.1371/journal.ppat.1008821
10.1016/j.imbio.2014.10.001
10.1073/pnas.092141999
10.18632/oncotarget.5739
10.1016/j.ctrv.2017.08.004
10.1097/MD.0000000000004328
10.1186/s12935-014-0086-8
10.1016/j.intimp.2021.107598
10.1089/scd.2020.0035
10.3389/fimmu.2021.623610
10.4049/jimmunol.168.7.3195
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|
[
"Rakhmatullina",
"Zolotykh",
"Filina",
"Valiullina",
"Zmievskaya",
"Gafurbaeva",
"Sagdeeva",
"Bulatov",
"Rizvanov",
"Miftakhova"
] |
[
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.\nDivision of Medical and Biological Sciences, Academy of Sciences of the Republic of Tatarstan, 420111 Kazan, Russia.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia."
] |
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[] | 6.24358 | 4.033785 |
39594628
| 212 |
Identification and Characterization of Fully Human FOLR1-Targeting CAR T Cells for the Treatment of Ovarian Cancer.
|
CAR T cell therapy has been an effective treatment option for hematological malignancies. However, the therapeutic potential of CAR T cells can be reduced by several constraints, partly due to immunogenicity and toxicities. The lack of established workflows enabling thorough evaluation of new candidates, limits comprehensive CAR assessment. To improve the selection of lead CAR candidates, we established a stringent, multistep workflow based on specificity assessments, employing multiple assays and technologies. Moreover, we characterized a human FOLR1-directed CAR binding domain. Selection of binding domains was based on extensive specificity assessment by flow cytometry and imaging, to determine on-/off-target and off-tumor reactivity. CAR T cell functionality and specificity were assessed by high-throughput screening and advanced in vitro assays. Our validation strategy highlights that assays comprehensively characterizing CAR functionality and binding specificity complement each other. Thereby, critical specificity considerations can be addressed early in the development process to overcome current limitations for future CAR T cell therapies.
|
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] | 2024-11-27 | 68 |
39594628
|
[
"CAR T cells",
"CAR T cell functionality",
"CAR T cell therapy",
"future CAR T cell therapies",
"comprehensive CAR assessment",
"CAR functionality",
"lead CAR candidates",
"specificity assessments",
"extensive specificity assessment",
"binding specificity",
"CAR",
"critical specificity considerations",
"specificity",
"binding domains",
"established workflows",
"new candidates",
"several constraints",
"multiple assays",
"flow cytometry",
"current limitations",
"thorough evaluation",
"a human FOLR1-directed CAR binding domain",
"hematological malignancies",
"assays",
"imaging",
"Selection",
"tumor",
"immunogenicity",
"FOLR1",
"an effective treatment option"
] |
[
"CAR T cells",
"FOLR1",
"high-throughput screening",
"immune cell engineering",
"immunotherapy",
"lead selection",
"phage panning",
"solid cancers",
"spatial multiplex",
"tissue cross-reactivity"
] | 0 |
10.3390/cells13221880
10.4049/jimmunol.2101058
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10.1016/S0140-6736(21)00933-8
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10.4049/jimmunol.162.9.5037
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10.1681/ASN.2004080711
|
[
"Bethke",
"Abramowski",
"Droste",
"Felsberger",
"Kochsiek",
"Kotter",
"Plettig",
"Antonova",
"Baghdo",
"Burzan",
"Tomszak",
"Martinez-Osuna",
"Eckardt",
"Herbel"
] |
[
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.",
"Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany."
] |
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[] | 8.252198 | 4.639681 |
39592597
| 213 |
CAR-T cell therapy in Multiple Myeloma: current status and future challenges.
|
The treatment of multiple myeloma has changed dramatically in recent years, with huge strides forward made in the field. Chimeric antigen receptor T-cell therapy targeting the B cell maturation antigen (BCMA) is now widely approved in relapsed refractory patients and is moving into earlier treatment lines. In this review, we discuss the evidence underpinning current regulatory approvals and consider mechanisms through which CAR-T cell efficacy could be improved. These include tackling BCMA-loss, harnessing the immunosuppressive tumour microenvironment, manufacturing concerns including the potential role of other cellular sources, safety issues such as cytokine release syndrome and neurotoxicity, and optimal patient selection.
|
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39592597
|
[
"relapsed refractory patients",
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"optimal patient selection",
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"other cellular sources",
"earlier treatment lines",
"recent years",
"huge strides",
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"the potential role",
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"the evidence",
"the field",
"this review",
"These",
"we",
"which"
] |
[] | 0 |
10.1038/s41408-024-01191-8
|
[
"Swan",
"Madduri",
"Hocking"
] |
[
"Department of Haematology, Austin Health, Melbourne, VIC, Australia. dawnswan123@gmail.com.",
"Department of Medicine, Blood and Marrow Transplantation, Stanford Hospital, Palo Alto, CA, USA.",
"Department of Haematology, Austin Health, Melbourne, VIC, Australia."
] |
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[] | 4.943978 | 6.141652 |
39589809
| 214 |
IL-2-inducible T cell kinase deficiency sustains chimeric antigen receptor T cell therapy against tumor cells.
|
Despite the revolutionary achievements of chimeric antigen receptor (CAR) T cell therapy in treating cancers, especially leukemia, several key challenges still limit its therapeutic efficacy. Of particular relevance is the relapse of cancer in large part, as a result of exhaustion and short persistence of CAR-T cells in vivo. IL-2-inducible T cell kinase (ITK) is a critical modulator of the strength of T-cell receptor (TCR) signaling, while its role in CAR signaling is unknown. By electroporation of clustered regularly interspaced short palindromic repeats (CRISPR) associated protein 9 (Cas9) ribonucleoprotein (RNP) complex into CAR-T cells, we successfully deleted ITK in CD19-CAR-T cells with high efficiency. Bulk and single-cell RNA sequencing (scRNA-seq) analyses revealed down-regulation of exhaustion and up-regulation of memory gene signatures in ITK-deficient CD19-CAR-T cells. Our results further demonstrated a significant reduction of T cell exhaustion and enhancement of T cell memory, with significant improvement of CAR-T cell expansion and persistence both in vitro and in vivo. Moreover, ITK-deficient CD19-CAR-T cells showed better control of tumor relapse. Our work provides a promising strategy of targeting ITK to develop sustainable CAR-T products for clinical use.
|
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] | 2024-11-26 | 1 |
39589809
|
[
"T cell exhaustion",
"T cell memory",
"T cell therapy",
"CAR-T cell expansion",
"CAR-T cells",
"CAR",
"T-cell receptor",
"ITK",
"short persistence",
"several key challenges",
"chimeric antigen receptor",
"memory gene signatures",
"CD19-CAR-T cells",
"ITK-deficient CD19-CAR-T cells",
"exhaustion",
"cancer",
"cancers",
"IL-2-inducible T cell kinase",
"tumor relapse",
"large part",
"sustainable CAR-T products",
"significant improvement",
"better control",
"clustered regularly interspaced short palindromic repeats",
"clinical use",
"particular relevance",
"persistence",
"CRISPR",
"protein",
"high efficiency"
] |
[
"Cancer immunotherapy",
"Hematology",
"Immunology",
"Leukemias",
"T cells"
] | 0 |
10.1172/JCI178558
|
[
"Fu",
"Huang",
"Xu",
"Liu",
"Li",
"Song",
"Deng",
"Tao",
"Zhang",
"Wang",
"Li",
"Sheng",
"Zhou",
"Han",
"Fu",
"Wang",
"Choudhary",
"Ye",
"Veggiani",
"Li",
"August",
"Huang",
"Shan",
"Peng"
] |
[
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Suzhou, China.",
"Lianshui People's Hospital of Kangda College, Nanjing Medical University, Lianshui, China.",
"Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.",
"Tianjin Mogenetics Biotech Co., Ltd., Tianjin, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Lianshui People's Hospital of Kangda College, Nanjing Medical University, Lianshui, China.",
"MegaRobo Technologies Co., Ltd., Suzhou, China.",
"MegaRobo Technologies Co., Ltd., Suzhou, China.",
"MegaRobo Technologies Co., Ltd., Suzhou, China.",
"Institute of Bioinformatics, University of Georgia, Athens, United States of America.",
"Institute of Bioinformatics, University of Georgia, Athens, United States of America.",
"Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, United States of America.",
"Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.",
"Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, United States of America.",
"Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, United States of America.",
"National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Suzhou, China.",
"Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China."
] |
[
"39589809"
] |
[] | 8.423177 | 5.193933 |
39589646
| 215 |
Accelerating CAR-T Cell Therapies with Small-Molecule Inhibitors.
|
Chimeric antigen receptor T-cell therapies have markedly improved the survival rates of patients with B-cell malignancies. However, their efficacy in other hematological cancers, such as acute myeloid leukemia, and in solid tumors has been limited. Key obstacles include the downregulation or loss of antigen expression on cancer cells, restricted accessibility to target cells, and the poor persistence of these "living drugs" because of the highly immunosuppressive tumor microenvironment. Additionally, manufacturing these immunotherapies presents significant challenges, and patients frequently experience side effects such as cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. This review emphasizes the potential of small-molecule inhibitors, many of which are already approved for clinical use, to facilitate chimeric antigen receptor T-cell manufacturing, enhance their anti-tumor efficacy, and mitigate their side effects. Although substantial work remains, the robust pre-clinical data and the growing clinical interest suggest significant promise for using cancer signaling pathway inhibitors to enhance and refine chimeric antigen receptor T-cell therapy for both hematological and solid tumors. Exploring these combination strategies could lead to more effective therapies, offering new hope for patients with resistant forms of cancer.
|
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] | 2024-11-26 | 137 |
39589646
|
[
"cancer cells",
"cells",
"other hematological cancers",
"Chimeric antigen receptor T-cell therapies",
"chimeric antigen receptor T-cell therapy",
"chimeric antigen receptor T-cell manufacturing",
"cancer",
"clinical use",
"solid tumors",
"patients",
"significant challenges",
"significant promise",
"side effects",
"pathway inhibitors",
"acute myeloid leukemia",
"antigen expression",
"cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome",
"the robust pre-clinical data",
"new hope",
"B-cell malignancies",
"Key obstacles",
"resistant forms",
"substantial work",
"their anti-tumor efficacy",
"loss",
"the growing clinical interest",
"small-molecule inhibitors",
"myeloid",
"more effective therapies",
"accessibility"
] |
[] | 0 |
10.1007/s40259-024-00688-9
|
[
"Mestermann",
"Garitano-Trojaola",
"Hudecek"
] |
[
"Medizinische Klinik und Poliklinik II, Lehrstuhl für zelluläre Immuntherapie, Universitätsklinikum Würzburg, Haus E4-/Raum 4.06, Versbacher Straße 5, 97078, Würzburg, Germany. Mestermann_K@ukw.de.\nFraunhofer-Institut für Zelltherapie und Immunologie, Außenstelle Zelluläre Immuntherapie, Würzburg, Germany. Mestermann_K@ukw.de.",
"Medizinische Klinik und Poliklinik II, Lehrstuhl für zelluläre Immuntherapie, Universitätsklinikum Würzburg, Haus E4-/Raum 4.06, Versbacher Straße 5, 97078, Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II, Lehrstuhl für zelluläre Immuntherapie, Universitätsklinikum Würzburg, Haus E4-/Raum 4.06, Versbacher Straße 5, 97078, Würzburg, Germany.\nFraunhofer-Institut für Zelltherapie und Immunologie, Außenstelle Zelluläre Immuntherapie, Würzburg, Germany."
] |
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[] | 9.229278 | 4.1937 |
39585688
| 216 |
Current and Future Roles of Chimeric Antigen Receptor T-Cell Therapy in Neurology: A Review.
|
Advancements in molecular engineering have facilitated the creation of engineered T cells that express synthetic receptors, termed chimeric antigen receptors (CARs). This is promising not only in cancer treatment but also in addressing a spectrum of other conditions. This review provides a comprehensive overview of the current approaches and future potential of CAR T-cell therapy in the field of neurology, particularly for primary brain tumors and autoimmune neurological disorders.
CAR T-cell therapy for glioblastoma is promising; however, first-in-human trials did not yield significant success or showed only limited success in a subset of patients. To date, the efficacy of CAR T-cell therapies has been demonstrated in animal models of multiple sclerosis, but larger human studies to corroborate the efficacy remain pending. CAR T cells showed efficacy in treatment of patients with relapsed or refractory aquaporin 4-immunoglobulin G-seropositive neuromyelitis optica spectrum disorders. Further studies with larger patient populations are needed to confirm these results. Success was reported also for treatment of cases with generalized myasthenia gravis using CAR T cells. Chimeric autoantibody receptor T cells, representing a modified form of CAR T cells directed against autoreactive B cells secreting autoantibodies, were used to selectively target autoreactive anti-N-methyl-d-aspartate B cells under in vitro and in vivo conditions, providing the basis for human studies and application to other types of autoimmune encephalitis associated with neuronal or glial antibodies.
CAR T cells herald a new era in the therapeutic landscape of neurological disorders. While their application in solid tumors, such as glioblastoma, has not universally yielded robust success, emerging innovative strategies show promise, and there is optimism for their effectiveness in certain autoimmune neurological disorders.
|
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] | 2024-11-25 | 1 |
39585688
|
[
"CAR T cells",
"engineered T cells",
"Chimeric autoantibody receptor T cells",
"autoreactive B cells",
"larger human studies",
"human studies",
"CAR T-cell therapy",
"certain autoimmune neurological disorders",
"autoimmune neurological disorders",
"larger patient populations",
"CAR T-cell therapies",
"neurological disorders",
"robust success",
"significant success",
"termed chimeric antigen receptors",
"cancer treatment",
"primary brain tumors",
"other conditions",
"Further studies",
"Success",
"other types",
"patients",
"treatment",
"synthetic receptors",
"emerging innovative strategies",
"generalized myasthenia gravis",
"autoimmune encephalitis",
"solid tumors",
"vivo conditions",
"efficacy"
] |
[] | 0 |
10.1001/jamaneurol.2024.3818
|
[
"Ismail",
"Gallus",
"Meuth",
"Okada",
"Hartung",
"Melzer"
] |
[
"Department of Neurology, Klinikum Vest, Academic Teaching Hospital of the Ruhr University Bochum, Recklinghausen, Germany.",
"Department of Neurological Surgery, University of California, San Francisco.\nDepartment of Neurosurgery, University Hospital Muenster, Muenster, Germany.",
"Department of Neurology, Medical Faculty and University Hospital, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany.",
"Department of Neurological Surgery, University of California, San Francisco.\nParker Institute for Cancer Immunotherapy, San Francisco, California.\nHelen Diller Family Comprehensive Cancer Center, San Francisco, California.",
"Department of Neurology, Medical Faculty and University Hospital, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany.\nBrain and Mind Center, University of Sydney, Sydney, New South Wales, Australia.\nDepartment of Neurology, Palacky University Olomouc, Olomouc, Czech Republic.",
"Department of Neurology, Medical Faculty and University Hospital, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany."
] |
[
"39585688"
] |
[] | 9.850259 | 7.312789 |
39582866
| 217 |
Optimizing cancer treatment: the synergistic potential of CAR-T cell therapy and CRISPR/Cas9.
|
Optimizing cancer treatment has become a pivotal goal in modern oncology, with advancements in immunotherapy and genetic engineering offering promising avenues. CAR-T cell therapy, a revolutionary approach that harnesses the body's own immune cells to target and destroy cancer cells, has shown remarkable success, particularly in treating acute lymphoblastic leukemia (ALL), and in treating other hematologic malignancies. While CAR-T cell therapy has shown promise, challenges such as high cost and manufacturing complexity remain. However, its efficacy in solid tumors remains limited. The integration of CRISPR/Cas9 technology, a powerful and precise genome-editing tool, also raises safety concerns regarding unintended edits and off-target effects, offers a synergistic potential to overcome these limitations. CRISPR/Cas9 can enhance CAR-T cell therapy by improving the specificity and persistence of CAR-T cells, reducing off-target effects, and engineering resistance to tumor-induced immunosuppression. This combination can also facilitate the knockout of immune checkpoint inhibitors, boosting the anti-tumor activity of CAR-T cells. Recent studies have demonstrated that CRISPR/Cas9-edited CAR-T cells can target previously untreatable cancer types, offering new hope for patients with refractory cancers. This synergistic approach not only enhances the efficacy of cancer treatment but also paves the way for personalized therapies tailored to individual genetic profiles. This review highlights the ongoing research efforts to refine this approach and explores its potential to revolutionize cancer treatment across a broader range of malignancies. As research progresses, the integration of CAR-T cell therapy and CRISPR/Cas9 holds the promise of transforming cancer treatment, making it more effective and accessible. This review explores the current advancements, challenges, and future prospects of this innovative therapeutic strategy.
|
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39582866
|
[
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"cancer treatment",
"refractory cancers",
"personalized therapies",
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"immune checkpoint inhibitors",
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"engineering resistance",
"individual genetic profiles",
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"target",
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"CRISPR/Cas9-edited CAR-T cells",
"promise",
"immunotherapy and genetic engineering offering",
"CRISPR/Cas9 technology",
"the bodys own immune cells",
"promising avenues",
"Recent studies",
"ALL"
] |
[
"CAR-T cell therapy",
"CRISPR/Cas9 technology",
"genetic engineering",
"immunotherapy",
"personalized cancer treatment"
] | 0 |
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10.1126/science.1231143
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10.1016/j.tranon.2021.101079
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10.3389/fonc.2021.627549
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10.1056/NEJMoa1407222
10.3389/fimmu.2022.795164
10.1002/cpt.v107.1
10.3389/fimmu.2022.927153
10.1038/leu.2017.145
10.1002/cam4.v9.16
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10.1038/s41375-019-0488-7
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10.1093/jnci/djz017
10.1016/j.jaci.2020.07.025
10.1038/s41409-020-01134-4
10.1053/j.ackd.2021.09.007
10.1158/2326-6066.CIR-13-0006
10.1182/blood-2013-08-519413
10.1038/mt.2010.24
10.1007/s00262-017-2034-7
10.1172/JCI86000
10.1200/JCO.2018.36.15_suppl.12079
10.1007/s13238-017-0411-9
10.5114/wo.2018.73892
10.1182/blood-2011-10-384388
10.1126/scitranslmed.3005930
10.1172/JCI125423
10.1126/scitranslmed.3008226
10.1186/s12943-023-01723-z
10.1186/s13046-022-02327-z
10.1590/1983-80422019272304
10.1016/j.celrep.2017.09.072
10.1007/s10528-022-10193-9
10.1172/JCI72992
10.1038/s41598-018-26756-z
10.1038/s41467-020-18875-x
10.1038/nrd.2016.238
10.1038/ng.3984
10.1038/s41586-019-1103-9
10.1016/j.cell.2015.02.038
10.1038/nn.4620
10.1186/s12575-021-00151-x
10.1080/14712598.2017.1338684
10.1038/mt.2015.151
10.1016/j.omtm.2021.04.009
10.1016/j.cell.2013.02.022
10.1038/nmeth.3312
10.1093/bfgp/elz039
10.1038/nmeth.2649
10.1007/s10529-014-1656-5
10.1073/pnas.2200626120
10.1016/j.immuni.2023.09.001
10.1038/nature21405
10.1038/nbt.2808
10.1038/nature16526
10.1038/nchembio.2559
10.1126/science.aad5227
10.1038/nbt.3190
10.1038/s41551-017-0145-2
10.1038/ncomms10548
10.1158/1078-0432.CCR-16-1300
10.1007/s11684-017-0543-6
10.3389/fphar.2018.01118
10.1158/0008-5472.CAN-18-0030
10.1038/s41375-018-0065-5
10.18632/oncotarget.15218
10.14348/molcells.2018.0242
10.3389/fonc.2019.00126
10.1038/s41375-018-0065-5
10.1182/blood.V130.Suppl_1.1914.1914
10.1172/jci.insight.99442
10.1182/blood.V126.23.116.116
10.1002/acg2.v1.1
10.1038/nature09328
10.1038/s41586-018-0326-5
10.1038/gt.2009.135
10.1038/nature13420
10.1158/2159-8290.CD-12-0548
10.1038/mto.2016.15
10.1016/j.blre.2015.10.003
10.1126/science.aba7365
10.1016/j.cell.2013.04.025
10.1038/cr.2016.142
10.1038/nature26155
10.1038/nmeth.2857
10.1038/nature24268
10.1038/ncomms15464
10.1038/nbt.2647
10.1038/mtna.2015.37
10.1016/j.cell.2016.10.044
10.1038/nbt.3198
10.1038/nbt.3481
10.3390/ijms241512317
10.1172/JCI83092
10.1158/2159-8290.CD-21-0407
10.1186/s40164-023-00435-w
10.3390/cancers13081926
10.1038/s41551-021-00842-6
10.1158/2159-8290.CD-22-1276
10.1002/cam4.2257
|
[
"Amiri",
"Moaveni",
"Majidi Zolbin",
"Shademan",
"Nourazarian"
] |
[
"Pediatric Urology and Regenerative Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.",
"Pediatric Urology and Regenerative Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.",
"Pediatric Urology and Regenerative Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.",
"Medical Journalism, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.",
"Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran."
] |
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] |
[] | 9.515622 | 3.000975 |
39580601
| 218 |
EEG features and synek scale indicate severity of neurotoxicity in adult patients treated with CD19 CAR T-cell therapy.
|
Patients who develop chimeric antigen receptor (CAR) T-cell-related immune effector cell-associated neurotoxicity syndrome (ICANS) frequently undergo evaluation with electroencephalography (EEG). We hypothesize that EEG features and Synek scale score, a measure of degree of EEG abnormality, are associated with ICANS severity. Here, we performed a retrospective review of 125 adult patients at Memorial Sloan Kettering Cancer Center (MSKCC) who received CAR-T cell therapy from 2010 to 2019, including 53 patients with B-acute lymphoblastic leukemia treated with 1928z CAR T cells (NCT01044069) and 72 patients with large B-cell lymphoma (LBCL) treated with the commercial CAR T products axicabtagene ciloleucel or tisagenlecleucel. We collected video EEG monitoring (27 with B-ALL and 20 with LBCL) and recorded daily EEG features, Synek scores, and ICANS grade for 47 eligible patients. Synek scale and ICANS grade were positively correlated (correlation coefficient 0.47, 95% CI: 0.31-0.60). This was further corroborated in the univariable model associating high Synek scale (3 or 4) with high ICANS grade (OR = 15.2; 95%CI:7.8-29.7, p < 0.0001). EEG features such as discontinuity, absence of posterior dominant rhythm, and presence of generalized sharp waves were statistically significantly associated with higher ICANS grade in univariable models. In the multivariable model, discontinuity (OR = 4.2 (95%CI:1.3-13.8, p = 0.02) and absence of posterior dominant rhythm (OR = 10.5 (95%CI:4.6-23.9, p < 0.0001) were statistically associated with higher ICANS grade. Overall, EEG discontinuity and absence of posterior dominant rhythm were independently associated with higher severity of neurotoxicity. Further, our data suggest that Synek Scale, may be a severity marker for neurotoxicity.
|
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] | 2024-11-24 | 23 |
39580601
|
[
"high ICANS grade",
"higher ICANS grade",
"ICANS grade",
"high Synek scale",
"ICANS severity",
"Synek scale score",
"EEG features",
"daily EEG features",
"EEG discontinuity",
"ICANS",
"posterior dominant rhythm",
"Synek scores",
"video EEG monitoring",
"higher severity",
"EEG abnormality",
"Patients",
"Synek Scale",
"EEG",
"Memorial Sloan Kettering Cancer Center",
"Synek",
"B",
"chimeric antigen receptor",
"univariable models",
"Synek scale",
"CAR-T cell therapy",
"large B-cell lymphoma",
"the commercial CAR T products axicabtagene ciloleucel",
"absence",
"generalized sharp waves",
"="
] |
[
"CAR T-cell therapy",
"EEG",
"ICANS",
"Immune-related adverse events",
"Synek"
] | 0 |
10.1038/s41598-024-80566-0
|
[
"Mao",
"Reiner",
"Chen",
"Park",
"Pennisi",
"Perales",
"Avila",
"Santomasso"
] |
[
"Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. maod@mskcc.org.\nMemorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. maod@mskcc.org.",
"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.",
"Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.\nDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.",
"Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA."
] |
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[] | 5.887917 | 4.401591 |
39577200
| 219 |
Hybrid Chimeric Antigen Receptor (CAR) γδ T Cells for Oral Cancer Therapy: Enhanced Safety and Targeted Efficacy.
| null |
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] | 2024-11-23 | 1 |
39577200
|
[] |
[] | 0 |
10.1016/j.clon.2024.103683
|
[
"Kamala",
"Sivaperumal"
] |
[
"Marine Microbial Research Lab, Department of Research and Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600 077, India; Centre for Marine and Aquatic Research (CMAR), Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602105, India.",
"Marine Biomedical Research Lab & Environmental Toxicology Unit, Cellular and Molecular Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600 077, India; Centre for Marine and Aquatic Research (CMAR), Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602105, India."
] |
[
"39577200"
] |
[] | 32.993107 | 7.51435 |
39576012
| 220 |
Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.
|
The application of chimeric antigen receptor (CAR) T cell therapy in solid tumors is hindered by life-threatening toxicities resulting from on-target, off-tumor killing of nonmalignant cells that express low levels of the target antigen. Mesothelin (MSLN) has been identified as a target antigen for CAR T cell treatment of mesothelioma, lung, ovarian, and other cancers because of its high expression on tumor cells and limited expression on mesothelial cells. However, fatal off-tumor toxicity of high-affinity MSLN-targeting CAR T cells has been reported in multiple clinical trials. In this study, we constructed CARs using mutant variants of a single-domain nanobody that bind both human and mouse MSLN with a wide range of affinities and examined tumor responses and their toxicities from on-target, off-tumor interactions in mouse models. CAR T cells with low nanomolar affinity (equilibrium dissociation constant, KD) exhibited profound systemic expansion with no apparent infiltration into the tumor. With a gradual reduction of CAR affinity toward the micromolar KD, the expansion of CAR T cells became more restricted to tumors. Our preclinical studies demonstrated that high-affinity MSLN CARs were associated with fatal on-target, off-tumor toxicity and that affinity-tuned CARs rendered T cells more selective for MSLN-high tumors.
|
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] | 2024-11-22 | 40 |
39576012
|
[
"CAR T cells",
"tumor cells",
"CAR T cell treatment",
"T cells",
"T cell therapy",
"CAR affinity",
"nonmalignant cells",
"mesothelial cells",
"solid tumors",
"tumor responses",
"tumor",
"tumors",
"CAR",
"CARs",
"low nanomolar affinity",
"affinities",
"high-affinity MSLN-targeting CAR T cells",
"high-affinity MSLN CARs",
"target",
"MSLN",
"profound systemic expansion",
"chimeric antigen receptor",
"MSLN-high tumors",
"affinity-tuned CARs",
"equilibrium dissociation constant",
"mutant variants",
"KD",
"multiple clinical trials",
"other cancers",
"limited expression"
] |
[
"Cancer immunotherapy",
"Cellular immune response",
"Mouse models",
"Oncology",
"Therapeutics"
] | 0 |
10.1172/jci.insight.186268
10.1073/pnas.93.1.136
10.1158/2159-8290.CD-15-0583
10.1158/1078-0432.CCR-13-1862
10.18632/oncotarget.3429
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10.1186/1476-4598-10-106
10.1056/NEJMra1706169
10.1016/j.ymthe.2019.07.015
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10.1016/S0090-8258(22)01537-2
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10.1128/JVI.72.11.8463-8471.1998
|
[
"Yang",
"Vedvyas",
"Alcaina",
"Trumper",
"Babu",
"Min",
"Tremblay",
"Shoemaker",
"Jin"
] |
[
"Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.\nDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.",
"Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.\nDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.",
"Department of Radiology, Weill Cornell Medicine, New York, New York, USA.",
"Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.",
"Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.",
"Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.\nDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.",
"Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.",
"Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.",
"Department of Radiology, Houston Methodist Research Institute, Houston, Texas, USA.\nDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA."
] |
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[] | 9.780196 | 5.932434 |
39572159
| 221 |
MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity.
|
The development of chimeric antigen receptor (CAR)-T cell therapies for solid tumors has attracted considerable attention, yet their clinical efficacy remains limited. Therefore, various efforts have been made to improve the efficacy of CAR-T cell therapy. As one promising strategy, incorporating the T-cell receptor (TCR) machinery into CAR structures has been reported to improve the efficacy of CAR-T cells in studies using conventional CARs targeting such as EGFR. However, in the case of peptide/major histocompatibility complex (pMHC)-targeted CARs, the advantages of exploiting TCR machinery have not been fully elucidated. We recently developed MAGE-A4-derived pMHC (MAGE-A4 pMHC)-targeted CAR-T cells (MA-CAR-T cells) using a highly specific human scFv antibody against MAGE-A4
We constructed a retroviral vector expressing Hybrid MA-TCR where MAGE-A4 pMHC-specific scFv are fused to human TCR constant chains.
Hybrid MA-TCR-T cells demonstrated superior in vitro functions compared with MA-CAR-T cells, while maintaining strict antigen specificity. In addition, functional superiority of Hybrid MA-TCR-T cells to MA-CAR-T cells became more pronounced on repetitive antigen stimulation. In particular, Hybrid MA-TCR-T cells significantly inhibited tumor growth in an immunodeficient mouse model more effectively than MA-CAR-T cells. Ex vivo analyses indicated that their enhanced therapeutic efficacy might result from higher infiltration of functionally active, less differentiated Hybrid MA-TCR-T cells in tumor tissues.
These findings suggest that leveraging the TCR machinery is a promising strategy for enhancing pMHC-targeted CAR-T cell therapy for solid tumors, potentially leading to more effective treatments.
|
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] | 2024-11-22 | 48 |
39572159
|
[
"TCR machinery",
"TCR",
"human TCR constant chains",
"CAR-T cell therapy",
"solid tumors",
"CAR-T cells",
"Hybrid MA-TCR",
"tumor growth",
"Hybrid MA-TCR-T cells",
"chimeric antigen receptor",
"tumor tissues",
"conventional CARs",
"CAR structures",
"pMHC-targeted CAR-T cell therapy",
"MA-CAR-T cells",
"repetitive antigen stimulation",
"strict antigen specificity",
"(CAR)-T cell therapies",
"CAR",
"Hybrid MA-TCR-T",
"(MAGE-A4 pMHC)-targeted CAR-T cells",
"the TCR machinery",
"MA-CAR",
"Ex vivo analyses",
"considerable attention",
"higher infiltration",
"vitro functions",
"their enhanced therapeutic efficacy",
"the T-cell receptor (TCR) machinery",
"functionally active, less differentiated Hybrid MA-TCR-T cells"
] |
[
"Adoptive cell therapy - ACT",
"Chimeric antigen receptor - CAR",
"Major histocompatibility complex - MHC",
"Solid tumor",
"T cell Receptor - TCR"
] | 0 |
10.1136/jitc-2024-010248
10.1056/NEJMoa1707447
10.1056/NEJMoa1709866
10.3389/fimmu.2018.02593
10.1038/s41571-023-00832-4
10.1056/NEJMoa2210859
10.1038/s41591-023-02612-0
10.1038/s41591-022-01800-8
10.1073/pnas.93.5.1820
10.4049/jimmunol.169.2.1110
10.1182/blood-2017-08-802926
10.1016/j.ymthe.2024.01.018
10.1038/s41408-021-00459-7
10.3389/fimmu.2022.1053120
10.1158/2326-6066.CIR-14-0186
10.1126/scitranslmed.aau7746
10.1038/s41467-023-40303-z
10.1038/nm.3838
10.1038/nbt.4086
10.1038/s41586-019-1805-z
10.1038/s41587-023-02060-8
10.1038/s41421-018-0066-6
10.1038/s41467-018-05395-y
10.1038/s41467-019-10097-0
10.1126/scitranslmed.abb5191
10.1038/s41591-021-01621-1
10.1158/0008-5472.CAN-06-3986
10.4049/jimmunol.1103020
10.1016/j.jim.2019.01.003
10.3390/ijms241310873
10.1016/j.isci.2023.107802
10.1016/j.immuni.2007.09.006
10.1038/s41586-019-1325-x
10.1016/j.ebiom.2022.103941
10.1016/j.xpro.2022.101954
10.1182/bloodadvances.2019000600
10.1172/JCI24480
10.3389/fimmu.2022.878209
10.1038/s41571-019-0297-y
10.1016/0006-291x(87)90502-x
10.1073/pnas.86.24.10024
10.1158/0008-5472.CAN-10-1322
10.4049/jimmunol.179.12.8243
10.1126/sciadv.abo0514
10.1038/nature21405
10.1038/mtna.2012.52
10.1158/2767-9764.CRC-21-0165
10.1038/s41551-020-00625-5
|
[
"Liu",
"Akahori",
"Imai",
"Wang",
"Negishi",
"Kato",
"Fujiwara",
"Miwa",
"Shiku",
"Miyahara"
] |
[
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan.",
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan.",
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan.",
"Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan.",
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan.",
"Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan.",
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan.",
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan.",
"Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan miyahr-y@med.mie-u.ac.jp."
] |
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[] | 9.204081 | 5.019451 |
39572158
| 222 |
IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors.
|
Oncofetal splice variants of extracellular matrix (ECM) proteins present a unique group of target antigens for the immunotherapy of pediatric cancers. However, limited data is available if these splice variants can be targeted with T cells expressing chimeric antigen receptors (CARs).
To determine the expression of the oncofetal version of tenascin C (TNC) encoding the C domain (C.TNC) in pediatric brain and solid tumors, we used quantitative reverse transcription PCR and immunohistochemistry. Genetically modified T cells were generated from human peripheral blood mononuclear cells and evaluated in vitro and in vivo.
We demonstrate that C.TNC is expressed on a protein level in pediatric tumors, including diffuse intrinsic pontine glioma, osteosarcoma, rhabdomyosarcoma, and Ewing sarcoma. We generate C.TNC-CAR T cells and establish that these recognize and kill C.TNC-positive tumor cells. However, their antitumor activity in vivo is limited. To improve the effector function of C.TNC-CAR T cells, we design a leucine zipper-based chimeric cytokine receptor that activates interleukin-18 signaling pathways (Zip18R). Expression of Zip18R in C.TNC-CAR T cells improves their ability to secrete cytokines and expand in repeat stimulation assays. C.TNC-CAR.Zip18R T cells also have significantly greater antitumor activity in vivo compared with unmodified C.TNC-CAR T cells.
Our study identifies the C domain of the ECM protein TNC as a promising CAR T-cell therapy for pediatric solid tumors and brain tumors. While we focus here on pediatric cancer, our work has relevance to a broad range of adult cancers that express C.TNC.
|
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] | 2024-11-22 | 74 |
39572158
|
[
"T cells",
"pediatric solid tumors",
"pediatric tumors",
"human peripheral blood mononuclear cells",
"pediatric cancer",
"pediatric cancers",
"unmodified C.TNC-CAR T cells",
"pediatric brain",
"solid tumors",
"C.TNC-CAR T cells",
"brain tumors",
"Oncofetal splice variants",
"C.TNC-positive tumor cells",
"CAR",
"CARs",
"quantitative reverse transcription PCR",
"intrinsic pontine glioma",
"adult cancers",
"C.TNC",
"chimeric antigen receptors",
"Genetically modified T cells",
"cytokines",
"repeat stimulation assays",
"tenascin C",
"ECM",
"extracellular matrix",
"TNC",
"vivo",
"a promising CAR T-cell therapy",
"C.TNC-CAR.Zip18R T cells"
] |
[
"Chimeric antigen receptor - CAR",
"Immunotherapy",
"T cell"
] | 0 |
10.1136/jitc-2024-009743
10.1002/eji.202049064
10.1016/j.ymthe.2020.09.015
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10.1136/jitc-2021-004479
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10.1158/2326-6066.CIR-22-0640
10.1158/1078-0432.CCR-23-3157
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10.1038/s41551-023-01143-w
10.1093/protein/gzl033
10.1038/nature23647
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10.1093/bioinformatics/btw777
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10.1002/1097-0142(19940201)73:3+<1076::aid-cncr2820731347>3.0.co;2-z
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|
[
"Wickman",
"Lange",
"Wagner",
"Ibanez",
"Tian",
"Lu",
"Sheppard",
"Chiang",
"Koo",
"Vogel",
"Langfitt",
"Perry",
"Shanmugam",
"Bell",
"Shaw",
"Krenciute",
"Zhang",
"Gottschalk"
] |
[
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.\nGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Biostatistics and Bioinformatics, H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
"Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA stephen.gottschalk@stjude.org."
] |
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[] | 9.409995 | 5.541444 |
39571171
| 223 |
Impact of prior CAR-T cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas.
|
Mosunetuzumab and other CD20/CD3 bispecific antibodies (BsAbs) have efficacy in B-cell lymphomas relapsing after or refractory to CD19-directed chimeric antigen receptor-modified T cells (CAR-T). The optimal timing of BsAbs and biomarkers of BsAb response after CAR-T are unknown. We addressed these questions using clinical data and blood samples from patients previously treated with CAR-T treated on a phase I/II study of mosunetuzumab (clinicaltrials.gov; NCT02500407). Thirty patients had paired samples at baseline and after 1 cycle of mosunetuzumab. Median time from CAR-T to mosunetuzumab was significantly longer for responding than for nonresponding patients (p=0.006, unadjusted for multiple comparisons). Most patients (20/30) did not receive intervening therapy between CAR-T administration and mosunetuzumab. The remainder of patients received one intervening therapy after a protocol-mandated drug washout. After mosunetuzumab, responding patients had higher lymphocytes (995 vs 400 cells/µL, p = 0.02) and greater increases in CD4 and CD8 cells (median change, 73 vs -90 cells/µL, p=0.005; 243 vs -103 cells/µL, p=0.004, respectively). Additionally, responding patients had an increase in activated CD8 cells (median 1.7-fold-change, p=0.02). Non-responders had a relative decrease in CAR transgene levels (N=16; p=0.04). This is the first study to assess changes in lymphocytes, T cells, and CAR transgene levels in patients treated with BsAb after CAR-T. These findings suggest an interaction between prior CAR-T and BsAb outcomes, and have implications for optimal timing of BsAb after CAR-T.
|
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] | 2024-11-21 | 1 |
39571171
|
[
"CAR transgene levels",
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"patients",
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"median change",
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"intervening therapy",
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"-103 cells/µL",
"CD19-directed chimeric antigen receptor-modified T cells",
"lymphocytes",
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"samples",
"prior CAR-T and BsAb outcomes",
"B-cell lymphomas",
"CAR-T.",
"multiple comparisons",
"cells/µL"
] |
[] | 0 |
10.1182/bloodadvances.2024013640
|
[
"Chong",
"Penuel",
"Napier",
"Lundberg",
"Budde",
"Shadman",
"Matasar",
"Bartlett",
"Flinn",
"Bosch",
"Fay",
"Goy",
"Kumar",
"Nastoupil",
"Wei",
"Wu",
"Yin",
"Fraietta",
"Chong",
"Schuster"
] |
[
"Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States.",
"Genentech, Inc., South San Francisco, California, United States.",
"University of Pennsylvania, Philadelphia, Pennsylvania, United States.",
"University of Pennsylvania, Philadelphia, Pennsylvania, United States.",
"City of Hope National Medical Center, Duarte, California, United States.",
"Fred Hutchinson Cancer Research Center, Seattle, Washington, United States.",
"Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States.",
"Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States.",
"Tennessee Oncology and OneOncology, Nashville, Tennessee, United States.",
"Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.",
"St Vincent's Hospital and Royal North Shore Hospital, Sydney, NSW, Australia.",
"John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey, United States.",
"Memorial Sloan Kettering Cancer Center, New York, New York, United States.",
"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.",
"Genentech, Inc., South San Francisco, California, United States.",
"Genentech, Inc., South San Francisco, California, United States.",
"Genentech, Inc., South San Francisco, California, United States.",
"University of Pennsylvania, Philadelphia, Pennsylvania, United States.",
"University of Pennsylvania, Philadelphia, Pennsylvania, United States.",
"Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States."
] |
[
"39571171"
] |
[] | 5.826178 | 5.688384 |
39570653
| 224 |
CD70: An Emerging Anticancer Target in Renal Cell Carcinoma and Beyond.
|
CD70 is an emerging target for anticancer therapies. It is an ideal antigen target given its limited expression in normal physiologic tissues and propensity to be aberrantly expressed in a variety of malignancies, thus limiting off-target toxicities. It is also heavily involved in immune homeostasis, and disruption of this pathway can help overcome tumor-related immune cell exhaustion. Recent phase I/II trials using cellular therapies targeting CD70, such as chimeric antigen receptor-T cells, have shown promising effectiveness and safety in treating relapsed or refractory renal cell carcinoma. Noncellular therapies targeting CD70, such as antibody-drug conjugates, monoclonal antibodies, radionuclides, and cytokines, are currently under investigation, with early data showing encouraging results as well. Efforts are already underway to further improve and optimize CD70-based therapies.
|
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] | 2024-11-21 | 1 |
39570653
|
[
"cellular therapies",
"CD70",
"anticancer therapies",
"Noncellular therapies",
"normal physiologic tissues",
"immune homeostasis",
"early data",
"promising effectiveness",
"chimeric antigen receptor-T cells",
"tumor-related immune cell exhaustion",
"relapsed or refractory renal cell carcinoma",
"CD70-based therapies",
"Recent phase",
"disruption",
"an ideal antigen target",
"malignancies",
"propensity",
"safety",
"investigation",
"I/II trials",
"antibody-drug conjugates",
"an emerging target",
"Efforts",
"results",
"its limited expression",
"-target",
"this pathway",
"a variety",
"It"
] |
[] | 0 |
10.1146/annurev-med-070623-045906
|
[
"Zang",
"Angeles",
"Pal"
] |
[
"1Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, California, USA; email: spal@coh.org.",
"2BC Cancer Agency, Vancouver, British Columbia, Canada.",
"1Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, California, USA; email: spal@coh.org."
] |
[
"39570653"
] |
[] | 10.858895 | 5.741714 |
39569202
| 225 |
CAR-T cell therapy for hepatocellular carcinoma: current trends and challenges.
|
Hepatocellular carcinoma (HCC) ranks among the most prevalent cancers worldwide, highlighting the urgent need for improved diagnostic and therapeutic methodologies. The standard treatment regimen generally involves surgical intervention followed by systemic therapies; however, the median survival rates for patients remain unsatisfactory. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a pivotal advancement in cancer treatment. Both clinical and preclinical studies emphasize the notable efficacy of CAR T cells in targeting HCC. Various molecules, such as GPC3, c-Met, and NKG2D, show significant promise as potential immunotherapeutic targets in liver cancer. Despite this, employing CAR T cells to treat solid tumors like HCC poses considerable challenges within the discipline. Numerous innovations have significant potential to enhance the efficacy of CAR T-cell therapy for HCC, including improvements in T cell trafficking, strategies to counteract the immunosuppressive tumor microenvironment, and enhanced safety protocols. Ongoing efforts to discover therapeutic targets for CAR T cells highlight the need for the development of more practical manufacturing strategies for CAR-modified cells. This review synthesizes recent findings and clinical advancements in the use of CAR T-cell therapies for HCC treatment. We elucidate the therapeutic benefits of CAR T cells in HCC and identify the primary barriers to their broader application. Our analysis aims to provide a comprehensive overview of the current status and future prospects of CAR T-cell immunotherapy for HCC.
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39569202
|
[
"CAR T cells",
"T cell trafficking",
"HCC treatment",
"CAR T-cell therapies",
"CAR T-cell therapy",
"HCC",
"systemic therapies",
"CAR T-cell immunotherapy",
"therapeutic targets",
"cancer treatment",
"potential immunotherapeutic targets",
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"significant promise",
"clinical advancements",
"significant potential",
"solid tumors",
"enhanced safety protocols",
"liver cancer",
"Chimeric antigen receptor (CAR) T-cell therapy",
"surgical intervention",
"recent findings",
"future prospects",
"strategies",
"Various molecules",
"considerable challenges",
"Numerous innovations",
"GPC3",
"c",
"Ongoing efforts",
"improved diagnostic and therapeutic methodologies"
] |
[
"antigen",
"chimeric antigen receptor T cell",
"gene therapy",
"hepatocellular carcinoma",
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|
[
"Zhou",
"Wei",
"Xu",
"Wu",
"Dou",
"Li",
"Zhang",
"Zhang"
] |
[
"Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.\nThe General Hospital of Western Theater Command, Chengdu, China.",
"Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan, China.",
"The General Hospital of Western Theater Command, Chengdu, China.",
"Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
"Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
"Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
"Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan, China.",
"Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan, China."
] |
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[] | 10.970166 | 3.992625 |
39568416
| 226 |
Predictors and implications of renal injury after CD19 chimeric antigen receptor T-cell therapy.
|
Chimeric Antigen Receptor (CAR) T cells targeting CD19 induce durable remissions in patients with relapsed or refractory non-Hodgkin lymphoma (NHL), but many patients experience treatmentrelated toxicity. Cytokine release syndrome and immune effector cell-associated neurologic syndrome are extensively characterized. However, limited data exist on the burden, predictors, and implications of acute kidney injury (AKI) after CAR T cell therapy. On initial screening of the FDA adverse event reporting system, we identified a disproportionately high rate of renal adverse events among nearly 6,000 CAR T adverse event reports, suggesting it is clinically important in this patient population. In a subsequent single-center analysis of 399 NHL patients treated with CD19 CAR T cells, we found a substantial burden of AKI after CAR T infusion (10% and 5% of any grade and grade ≥2 AKI) with pre-renal causes being predominant (72%). Evolution to chronic kidney disease was rare, however, 3 patients required hemodialysis. Importantly, patients experiencing cytokine release syndrome and/or neurotoxicity as well as those with low serum albumin and high inflammatory cytokines, including IL-6 and TNF-alpha, were more likely to develop AKI. While pre-CAR T renal dysfunction was not associated with adverse outcomes, patients developing post-CAR T AKI had lower overall survival compared to their counterparts. Our findings indicate that renal dysfunction is a common toxicity of CAR T cell therapy with meaningful prognostic impact. Notably, the link between systemic inflammation and renal dysfunction, suggests that readily available biomarkers may inform on renal injury risk after CAR T cell therapy.
|
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] | 2024-11-21 | 1 |
39568416
|
[
"CAR T cell therapy",
"pre-CAR T renal dysfunction",
"CD19 CAR T cells",
"CAR T infusion",
"renal adverse events",
"renal dysfunction",
"pre-renal causes",
"post-CAR T AKI",
"many patients",
"renal injury risk",
"patients",
"cytokine release syndrome",
"non-Hodgkin",
"AKI",
"high inflammatory cytokines",
"adverse outcomes",
"CAR",
"lower overall survival",
"low serum albumin",
"chronic kidney disease",
"acute kidney injury",
"Cytokine release syndrome and immune effector cell-associated neurologic syndrome",
"nearly 6,000 CAR T adverse event reports",
"the FDA adverse event reporting system",
"relapsed or refractory non-Hodgkin lymphoma",
"NHL",
"treatmentrelated toxicity",
"durable remissions",
"399 NHL patients",
"meaningful prognostic impact"
] |
[] | 0 |
10.3324/haematol.2024.286021
|
[
"Boardman",
"Gutgarts",
"Flynn",
"Devlin",
"Goldman",
"Tomas",
"Fein",
"Slingerland",
"Parascondola",
"Lin",
"Scordo",
"Dahi",
"Giralt",
"Palomba",
"Salles",
"Nath",
"Walji",
"Corona",
"Park",
"Shah",
"Perales",
"Jaffer-Sathick",
"Shouval"
] |
[
"Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, NY; Renal Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York.",
"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York.",
"Department of Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Aviv University, Israel.",
"Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Hematology and Hemotherapy Service, Hospital Universitario Gregorio Marañón, Madrid, Spain.",
"Department of Medicine, Weill Cornell Medical College, New York.",
"Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York.",
"Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Hematology and Hemotherapy Service, Hospital Universitario Ramón y Cajal, Madrid, Spain.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, NY; Renal Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.",
"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Aviv University, Israel. shouvalr@mskcc.org."
] |
[
"39568416"
] |
[] | 5.953009 | 4.264222 |
39566469
| 227 |
Solid tumor immunotherapy using NKG2D-based adaptor CAR T cells.
|
NKG2D ligands (NKG2DLs) are broadly expressed in cancer. To target these, we describe an adaptor chimeric antigen receptor (CAR) termed NKG2D/Dap10-12. Herein, T cells are engineered to co-express NKG2D with a fusion protein that comprises Dap10 joined to a Dap12 endodomain. NKG2D/Dap10-12 T cells elicit compelling efficacy, eradicating or controlling NKG2DL-expressing tumors in several established xenograft models. Importantly, durable responses, long-term survival, and rejection of tumor re-challenge are reproducibly achieved. Efficacy is markedly superior to a clinical stage CAR analog, comprising an NKG2D-CD3ζ fusion. Structure-function analysis using an extended CAR panel demonstrates that potency is dependent on membrane proximity of signaling units, high NKG2D cell surface expression, adaptor structure, provision of exogenous Dap10, and inclusion of one rather than three immune tyrosine activation motifs per signaling unit. Potent therapeutic impact of NKG2D/Dap10-12 T cells is also underpinned by enhanced oxidative phosphorylation, reduced senescence, and transcriptomic re-programming for increased ribosomal biogenesis.
|
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] | 2024-11-21 | 67 |
39566469
|
[
"high NKG2D cell surface expression",
"exogenous Dap10",
"tumor re",
"Dap10",
"express NKG2D",
"adaptor structure",
"transcriptomic re",
"NKG2D ligands",
"signaling unit",
"signaling units",
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"CAR",
"-",
"increased ribosomal biogenesis",
"reduced senescence",
"membrane proximity",
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"Potent therapeutic impact",
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"a clinical stage CAR analog",
"an adaptor chimeric antigen receptor",
"rejection",
"an extended CAR panel",
"T cells",
"inclusion",
"provision",
"long-term survival",
"NKG2D/Dap10-12 T cells"
] |
[
"Dap10",
"Dap12",
"NKG2D",
"adaptor",
"chimeric antigen receptor"
] | 0 |
10.1016/j.xcrm.2024.101827
10.3390/biology12081079
10.1038/ncomms13930
10.1016/j.immuni.2008.02.016
10.1093/immadv/ltab004
10.1182/blood-2004-11-4365
10.1016/j.ymthe.2020.08.016
10.1016/j.omto.2020.04.013
10.1371/journal.pone.0031210
10.1158/1078-0432.CCR-17-0075
10.1186/s13045-018-0635-z
10.1158/0008-5472.CAN-12-3558
10.1089/hum.2012.143
10.1158/2326-6066.CIR-18-0307
10.1016/S2352-3026(22)00378-7
10.3389/fimmu.2018.02940
10.1158/1078-0432.CCR-19-3417
10.4161/self.2.1.14790
10.1158/2326-6066.CIR-15-0054
10.1182/blood-2011-04-346825
10.1016/j.omto.2022.06.003
10.1038/nature01112
10.1007/s00262-008-0585-3
10.1080/2162402X.2017.1339854
10.1136/bmjopen-2017-017075
10.1016/j.xcrm.2021.100457
10.1016/j.smim.2023.101840
10.4161/2162402X.2014.994446
10.1038/s41590-020-0725-2
10.1038/nbt0102-70
10.4049/jimmunol.0900447
10.1038/s41591-018-0290-5
10.1111/cei.13478
10.1172/JCI133215
10.1158/1535-7163.MCT-17-1097
10.1002/eji.200636195
10.1083/jcb.201009094
10.1038/s41587-023-01687-x
10.1126/scitranslmed.add1951
10.1182/blood-2023-187665
10.1126/sciimmunol.abh4271
10.1016/j.intimp.2022.109253
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10.1042/BCJ20220144
10.1186/s13075-018-1783-9
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10.1016/j.jaci.2014.02.019
10.1038/s41587-019-0246-4
10.1016/j.autrev.2013.04.001
10.1016/j.cell.2018.10.028
10.1038/nm.2129
10.1093/nar/27.2.573
10.1002/cyto.a.21015
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10.1093/nar/gkac958
10.1016/j.cels.2015.12.004
10.1073/pnas.0506580102
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10.2119/molmed.2011.00493
10.3390/cancers11050674
10.1371/journal.pcbi.1007664
10.1002/sim.4780090710
10.1093/bioinformatics/btr260
10.1007/978-0-387-98141-3
|
[
"Obajdin",
"Larcombe-Young",
"Glover",
"Kausar",
"Hull",
"Flaherty",
"Tan",
"Beatson",
"Dunbar",
"Mazza",
"Bove",
"Taylor",
"Bille",
"Spillane",
"Cozzetto",
"Vigilante",
"Schurich",
"Davies",
"Maher"
] |
[
"King's College London, School of Cancer and Pharmaceutical Sciences, CAR Mechanics Lab, London SE1 9RT, UK.",
"King's College London, School of Cancer and Pharmaceutical Sciences, CAR Mechanics Lab, London SE1 9RT, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"King's College London, Department of Infectious Diseases, School of Immunology and Microbial Sciences, Guy's Hospital, London SE1 9RT, UK.",
"King's College London, School of Cancer and Pharmaceutical Sciences, CAR Mechanics Lab, London SE1 9RT, UK.",
"Department of Respiratory Medicine, Division of Medicinal Sciences, University College London, London, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"Department of Thoracic Surgery, Guy's and St. Thomas' NHS Trust Foundation, London SE1 9RT, UK.",
"Department of Physics, King's College London, London WC2R 2LS, UK.",
"Division of Digestive Diseases, Faculty of Medicine, Imperial College London, London W12 0NN, UK.",
"King's College London, Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, Guy's Hospital, London SE1 9RT, UK.",
"King's College London, Department of Infectious Diseases, School of Immunology and Microbial Sciences, Guy's Hospital, London SE1 9RT, UK.",
"Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK.",
"King's College London, School of Cancer and Pharmaceutical Sciences, CAR Mechanics Lab, London SE1 9RT, UK; Leucid Bio Ltd, Guy's Hospital, London SE1 9RT, UK; Department of Immunology, Eastbourne Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD, UK. Electronic address: john.maher@kcl.ac.uk."
] |
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[] | 11.241684 | 5.948632 |
39563035
| 228 |
ARI0003: Co-transduced CD19/BCMA dual-targeting CAR-T cells for the treatment of non-Hodgkin lymphoma.
|
CD19 CAR-T therapy has achieved remarkable responses in relapsed/refractory non-Hodgkin lymphoma (NHL). However, challenges persist, with refractory responses or relapses after CAR-T administration linked to CD19 loss or downregulation. Given the co-expression of CD19 and BCMA in NHL, we hypothesized that dual targeting could enhance long-term efficacy. We optimized different dual-targeting approaches, including co-transduction of two lentiviral vectors, bicistronic, tandem, and loop and pool strategies, based on our academic anti-CD19 (ARI0001) and anti-BCMA (ARI0002h) CAR-T cells. Comparison with anti-CD19/CD20 or anti-CD19/CD22 dual targeting was also performed. We demonstrate that anti-CD19/BCMA CAR-T cells can be effectively generated through the co-transduction of two lentiviral vectors after optimization to minimize competition for cellular resources. Co-transduced T cells, called ARI0003, effectively targeted NHL tumor cells with high avidity, outperforming anti-CD19 CAR-T cells and other dual-targeting approaches both in vitro and in vivo, particularly in low CD19 antigen density models. ARI0003 maintained effectiveness post-CD19 CAR-T treatment in xenograft models and in spheroids from relapsed CART-treated patients. ARI0003 CAR-T cells were effectively manufactured under Good Manufacturing Practice conditions, with a reduced risk of genotoxicity compared to other dual-targeting approaches. A first-in-human phase 1 clinical trial (CARTD-BG-01; this study was registered at ClinicalTrials.gov [NCT06097455]) has been initiated to evaluate the safety and efficacy of ARI0003 in NHL.
|
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] | 2024-11-20 | 1 |
39563035
|
[
"anti-BCMA",
"NHL tumor cells",
"outperforming anti-CD19 CAR-T cells",
"non-Hodgkin",
"low CD19 antigen density models",
"effectiveness post-CD19 CAR-T treatment",
"Co-transduced T cells",
"anti-CD19/BCMA CAR-T cells",
"refractory responses",
"anti-CD19/CD20 or anti-CD19/CD22 dual targeting",
"dual targeting",
"Good Manufacturing Practice conditions",
"relapsed/refractory non-Hodgkin lymphoma",
"ARI0003 CAR-T cells",
"NHL",
"CD19 loss",
"remarkable responses",
"co",
"CD19 CAR-T therapy",
"Good Manufacturing Practice",
"-",
"xenograft models",
"CD19",
"transduction",
"high avidity",
"BCMA",
"ARI0003",
"efficacy",
"cellular resources",
"CAR-T administration"
] |
[
"CAR-T cells",
"co-transduction",
"dual targeting",
"lymphoma"
] | 0 |
10.1016/j.ymthe.2024.11.028
|
[
"Bachiller",
"Barceló-Genestar",
"Rodriguez-Garcia",
"Alserawan",
"Dobaño-López",
"Giménez-Alejandre",
"Castellsagué",
"Colell",
"Otero-Mateo",
"Antoñana-Vildosola",
"Español-Rego",
"Ferruz",
"Pascal",
"Martín-Antonio",
"Anguela",
"Fillat",
"Olesti",
"Calvo",
"Juan",
"Delgado",
"Pérez-Galán",
"Urbano-Ispizua",
"Guedan"
] |
[
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Department of Immunology, Hospital Clínic, 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red-Oncología (CIBERONC), 28029 Madrid, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Department of Immunology, Hospital Clínic, 08036 Barcelona, Spain.",
"Centre for Genomic Regulation (CRG), Barcelona Institute for Science and Technology, 08003 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Department of Immunology, Hospital Clínic, 08036 Barcelona, Spain; University of Barcelona, 08034 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Instituto de Salud Carlos III, 28029 Madrid, Spain.",
"Estuary Biotherapeutics, Philadelphia, PA 19104, USA.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación en Red-Enfermedades Raras (CIBERER), 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; University of Barcelona, 08034 Barcelona, Spain; Department of Clinical Pharmacology, Hospital Clínic, 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; University of Barcelona, 08034 Barcelona, Spain; Department of Clinical Pharmacology, Hospital Clínic, 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Department of Immunology, Hospital Clínic, 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red-Oncología (CIBERONC), 28029 Madrid, Spain; University of Barcelona, 08034 Barcelona, Spain; Department of Hematology, Hospital Clínic, 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red-Oncología (CIBERONC), 28029 Madrid, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain; University of Barcelona, 08034 Barcelona, Spain; Department of Hematology, Hospital Clínic, 08036 Barcelona, Spain.",
"Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain. Electronic address: sguedan@recerca.clinic.cat."
] |
[
"39563035"
] |
[] | 6.910204 | 5.391012 |
39562721
| 229 |
Graft-versus-host disease after anti-CD19 chimeric antigen receptor T-cell therapy following allogeneic hematopoietic cell transplantation: a transplant complications and paediatric diseases working parties joint EBMT study.
|
In patients diagnosed with B-acute lymphoblastic leukemia (B-ALL) or B-non-Hodgkin's lymphoma (B-NHL) relapsing after allogeneic stem cell transplantation (allo-HCT), it is a standard practice to perform anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. When collected from the patient after allo-HCT, the produced CAR-T cells are likely to be donor T-cell-derived, creating unknown safety risks due to their potential allo-reactivity. We therefore performed an EBMT registry-based study on the incidence of graft-versus-host disease (GvHD) in this setting. We included 257 allo-HCT patients (n = 172 ≥ 18 years) with B-ALL or B-NHL, treated with anti-CD19 CAR T-cells (tisagenlecleucel n = 184, brexucabtagene autoleucel n = 43 and axicabtagene ciloleucel n = 30), between 2018 and 2022. Three patients developed aGvHD, whereas 6 patients developed cGvHD after CAR T-cell. The 100-day cumulative incidence (CI) of new aGvHD was 1.6% and the 12-month CI of new cGvHD was 2.8%. The 1-year GvHD relapse-free survival and non-relapse mortality were 52.1% and 4.7%, respectively. Last, with a median follow up of 18.8 months, the 1-year overall survival was 76.8%. In summary, the GvHD rate in allo-HCT patients treated with CAR T-cell therapy is relatively low. Our data support the view that GvHD is not a major safety issue in this setting.
|
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] | 2024-11-20 | 30 |
39562721
|
[
"allogeneic stem cell transplantation",
"anti-CD19 chimeric antigen receptor",
"non-relapse mortality",
"unknown safety risks",
"anti-CD19 CAR T-cells",
"HCT",
"GvHD",
"patients",
"CAR T-cell therapy",
"new cGvHD",
"CAR T-cell",
"allo",
"=",
"allo-HCT patients",
"B",
"new aGvHD",
"CI",
"cGvHD",
"the produced CAR-T cells",
"B-acute lymphoblastic leukemia",
"host",
"257 allo-HCT patients",
"(CAR) T-cell therapy",
"a major safety issue",
"B-NHL",
"tisagenlecleucel",
"the GvHD rate",
"brexucabtagene",
"aGvHD",
"-"
] |
[] | 0 |
10.1038/s41375-024-02467-5
10.1126/science.aar6711
10.1056/NEJMoa1707447
10.1056/NEJMoa1804980
10.1016/S0140-6736(20)31366-0
10.1016/j.bbmt.2010.06.008
10.1056/NEJMoa2300709
10.1038/s41467-022-29668-9
10.1126/sciimmunol.abl3642
10.1016/j.bbmt.2018.12.758
10.1056/NEJMra1609337
10.1056/NEJMra1703472
10.1200/JCO.1997.15.2.433
10.1038/nm.4258
10.1200/JCO.2015.64.5929
10.1182/blood-2013-08-519413
10.1080/2162402X.2015.1027469
10.1111/bjh.17121
10.1016/S0140-6736(20)32334-5
10.1182/blood-2017-08-752121
10.3389/fimmu.2022.887866
10.1016/j.bbmt.2006.01.008
10.1016/j.bbmt.2015.02.025
10.1016/S2352-3026(19)30256-X
10.1111/bjh.17737
10.1182/blood-2015-08-664250
10.1016/j.ccell.2015.09.004
10.1016/j.immuni.2016.01.021
10.1172/JCI85309
10.1126/scitranslmed.aaf8621
10.1182/blood-2017-02-769208
10.1182/blood-2016-01-628982
10.1172/JCI165476
10.1182/blood-2010-01-262089
10.1038/bmt.2009.177
|
[
"Ortí",
"Peczynski",
"Boreland",
"O'Reilly",
"von Bonin",
"Balduzzi",
"Besley",
"Kalwak",
"Ryhänen",
"Güngör",
"Wynn",
"Bader",
"Mielke",
"Blaise",
"Amrolia",
"Yakoub-Agha",
"Calkoen",
"Schubert",
"Potter",
"Pichler",
"Kröger",
"Kwon",
"Sengeloev",
"Torrent",
"Chalandon",
"van Gorkom",
"Koenecke",
"Graham",
"Schoemans",
"Moiseev",
"Penack",
"Peric"
] |
[
"Department of Hematology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. gorti@vhio.net.",
"EBMT Paris Data Office, Saint Antoine Hospital, Paris, France.",
"EBMT Paris Data Office, Saint Antoine Hospital, Paris, France.",
"University College London Hospital, London, UK.",
"Universitaetsklinikum Dresden, Dresden, Germany.",
"Pediatric Hematopoietic Transplant Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.\nSchool of Medicine and Surgery, Milano-Bicocca University, Milan, Italy.",
"University Hospitals Bristol and Weston NHSFT, Bristol, UK.",
"Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland.",
"University of Helsinki and Helsinki University Hospital, Children´s Hospital, and Pediatric Research CenterDivision of Hematology, Oncology, and Stem Cell Transplantation, Helsinki, Finland.",
"Division of Hematology/Oncology/Immunology, Gene-therapy, and Stem Cell Transplantation, University Children's Hospital - Eleonore Foundation & Children's Research Center (CRC), Zürich, Switzerland.",
"Royal Manchester Children's Hospital, Manchester, UK.",
"Goethe University, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Frankfurt Main, Germany.",
"Karolinska University Hospital, Stockholm, Sweden.",
"Programme de Transplantation & Therapie Cellulaire, Marseille, France.",
"Department of Bone Marrow Transplant, Great Ormond St Children's Hospital, London, UK.",
"CHU de Lille, Univ de Lille, INSERM U1286, Infinite, 59000, Lille, France.",
"Princess Maxima Center. University Hospital for Children (WKZ), Utrecht, Netherlands.",
"University of Heidelberg, Heidelberg, Germany.",
"Kings College Hospital, London, UK.",
"Department of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.\nChildren's Cancer Research Institute, Medical University of Vienna, Vienna, Austria.",
"University Hospital Eppendorf, Hamburg, Germany.",
"Department of Hematology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.",
"Rigshospitalet, Copenhagen, Denmark.",
"ICO-Badalona. Hospital Universitari Germans Trias i Pujol, Badalona, Spain.",
"Hôpitaux Universitaires de Genève, Hematology Division and Faculty of Medicine, University of Geneva, Geneva, Switzerland.",
"University Hospital Maastricht, Maastricht, Netherlands.",
"Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.",
"Comprehensive Cancer Centre, King's College London, London, UK.",
"Department of Hematology, University Hospitals Leuven and Department of Public Health and Primary Care, ACCENT VV, KU Leuven - University of Leuven, Leuven, Belgium.",
"RM Gorbacheva Research Institute, Pavlov University, St Petersburg, Russia.",
"Medical Clinic, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Tumorimmunology, Augustenburger Platz 1, 13353, Berlin, Germany.\nBerlin Institute of Health at Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.",
"University Hospital Centre Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia."
] |
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[] | 6.420393 | 5.544801 |
39562005
| 230 |
Preclinical evaluation of antigen-sensitive B7-H3-targeting nanobody-based CAR-T cells in glioblastoma cautions for on-target, off-tumor toxicity.
|
Glioblastoma is the most common lethal primary brain tumor, urging evaluation of new treatment options. Chimeric antigen receptor (CAR)-T cells targeting B7 homolog 3 (B7-H3) are promising because of the overexpression of B7-H3 on glioblastoma cells but not on healthy brain tissue. Nanobody-based (nano)CARs are gaining increasing attention as promising alternatives to classical single-chain variable fragment-based (scFv)CARs, because of their single-domain nature and low immunogenicity. Still, B7-H3 nanoCAR-T cells have not been extensively studied in glioblastoma.
B7-H3 nanoCAR- and scFvCAR-T cells were developed and evaluated in human glioblastoma models. NanoCAR-T cells targeting an irrelevant antigen served as control. T cell activation, cytokine secretion and killing capacity were evaluated in vitro using ELISA, live cell imaging and flow cytometry. Antigen-specific killing was assessed by generating B7-H3 knock-out cells using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-genome editing. The tumor tracing capacity of the B7-H3 nanobody was first evaluated in vivo using nuclear imaging. Then, the therapeutic potential of the nanoCAR-T cells was evaluated in a xenograft glioblastoma model.
We showed that B7-H3 nanoCAR-T cells were most efficient in lysing B7-H3
B7-H3 nanoCAR-T cells showed promise for glioblastoma therapy following in vitro characterization, but limiting in vivo toxicity was observed. Off-tumor recognition of healthy mouse tissue by the cross-reactive B7-H3 nanoCAR-T cells was identified as a potential cause for this toxicity, warranting caution when using highly sensitive nanoCAR-T cells, recognizing the low-level expression of B7-H3 on healthy tissue.
|
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] | 2024-11-20 | 51 |
39562005
|
[
"T cell activation",
"glioblastoma cells",
"CAR)-T cells",
"B7 homolog",
"NanoCAR-T cells",
"B7-H3 nanoCAR-T cells",
"scFvCAR-T cells",
"healthy brain tissue",
"glioblastoma therapy",
"human glioblastoma models",
"healthy mouse tissue",
"the cross-reactive B7-H3 nanoCAR-T cells",
"healthy tissue",
"B7-H3\nB7-H3 nanoCAR-T cells",
"live cell imaging and flow cytometry",
"glioblastoma",
"killing capacity",
"highly sensitive nanoCAR-T cells",
"B7-H3",
"promising alternatives",
"vivo toxicity",
"Chimeric antigen receptor",
"the nanoCAR-T cells",
"new treatment options",
"tumor",
"B7-H3 knock-out cells",
"increasing attention",
"vitro characterization",
"low immunogenicity",
"B7-H3 nanoCAR-"
] |
[
"Adoptive cell therapy - ACT",
"Chimeric antigen receptor - CAR",
"Immunotherapy",
"Solid tumor",
"T cell"
] | 0 |
10.1136/jitc-2024-009110
10.3322/caac.21613
10.1007/978-3-030-96376-7_5
10.1007/s11060-020-03448-1
10.1038/s41571-018-0003-5
10.1038/s41593-018-0227-9
10.1038/s41593-020-00789-y
10.1136/jitc-2020-002296
10.3389/fimmu.2023.1183641
10.7554/eLife.52176
10.1056/NEJMra1706169
10.1038/s41586-022-04489-4
10.1126/scitranslmed.aaa0984
10.3389/fonc.2021.669071
10.1001/jamaoncol.2017.0184
10.1158/1078-0432.CCR-15-0428
10.3389/fonc.2021.694941
10.1056/NEJMoa1610497
10.1038/s41571-019-0297-y
10.1158/1078-0432.CCR-18-0432
10.3389/fimmu.2021.701006
10.1158/1078-0432.CCR-20-2584
10.4049/jimmunol.168.12.6294
10.1186/s12943-023-01751-9
10.1002/stem.2944
10.1038/s41392-021-00505-7
10.1002/med.21818
10.3389/fimmu.2021.632687
10.7150/thno.34941
10.1016/bs.ircmb.2022.03.010
10.1038/leu.2013.292
10.1073/pnas.89.10.4285
10.3390/cancers12123582
10.1002/anbr.202100124
10.1016/j.ymthe.2021.05.006
10.1007/978-1-61779-974-7_8
10.1096/fj.10-180331
10.1007/978-1-61779-968-6_30
10.3389/fimmu.2023.1268900
10.1016/j.ccell.2017.03.005
10.1016/j.ccell.2017.03.009
10.1016/j.ccell.2019.01.002
10.1002/ijc.28474
10.1042/BSR20211986
10.1158/2767-9764.CRC-23-0538
10.1016/j.omtm.2022.08.008
10.2217/nnm.13.86
10.1038/s41467-023-41631-w
10.1016/j.ebiom.2020.102931
10.3389/fimmu.2023.1321596
10.1007/s00018-021-04089-x
10.1093/neuonc/noaa278
|
[
"Meeus",
"Funeh",
"Awad",
"Zeven",
"Autaers",
"De Becker",
"Van Riet",
"Goyvaerts",
"Tuyaerts",
"Neyns",
"Devoogdt",
"De Vlaeminck",
"Breckpot"
] |
[
"Translational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Molecular and Cellular Therapy (LMCT), Vrije Universiteit Brussel, Brussels, Belgium fien.meeus@vub.be.\nDepartment of Medical Imaging (MIMA), Molecular Imaging and Therapy (MITH) research group, Vrije Universiteit Brussel, Brussels, Belgium.",
"Department of Medical Imaging (MIMA), Molecular Imaging and Therapy (MITH) research group, Vrije Universiteit Brussel, Brussels, Belgium.",
"Translational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Molecular and Cellular Therapy (LMCT), Vrije Universiteit Brussel, Brussels, Belgium.",
"Department of Medical Imaging (MIMA), Molecular Imaging and Therapy (MITH) research group, Vrije Universiteit Brussel, Brussels, Belgium.",
"Translational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Molecular and Cellular Therapy (LMCT), Vrije Universiteit Brussel, Brussels, Belgium.",
"Department of Hematology, Cellular Therapy Laboratory, University Hospital Brussels, Universitair Ziekenhuis Brussel, Brussels, Belgium.",
"Department of Hematology, Cellular Therapy Laboratory, University Hospital Brussels, Universitair Ziekenhuis Brussel, Brussels, Belgium.\nTranslational Oncology Research Center (TORC), Department of Biomedical Sciences, Hematology and Immunology Research Team (HEIM), Vrije Universiteit Brussel, Brussels, Belgium.",
"Department of Medical Imaging (MIMA), Molecular Imaging and Therapy (MITH) research group, Vrije Universiteit Brussel, Brussels, Belgium.",
"Department of Medical Oncology, University Hospital Brussels, Universitair Ziekenhuis Brussel, Brussels, Belgium.\nTranslational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Medical and Molecular Oncology (LMMO), Vrije Universiteit Brussel, Brussels, Belgium.",
"Department of Medical Oncology, University Hospital Brussels, Universitair Ziekenhuis Brussel, Brussels, Belgium.\nTranslational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Medical and Molecular Oncology (LMMO), Vrije Universiteit Brussel, Brussels, Belgium.",
"Department of Medical Imaging (MIMA), Molecular Imaging and Therapy (MITH) research group, Vrije Universiteit Brussel, Brussels, Belgium.",
"Translational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Molecular and Cellular Therapy (LMCT), Vrije Universiteit Brussel, Brussels, Belgium.",
"Translational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Molecular and Cellular Therapy (LMCT), Vrije Universiteit Brussel, Brussels, Belgium."
] |
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[] | 10.117903 | 7.071774 |
39561966
| 231 |
Hepatocellular carcinoma systemic treatment 2024 update: from early to advanced stage.
|
Hepatocellular carcinoma (HCC) ranks the sixth most common malignancy but the third leading cause of cancer-related mortality in the world. Significant breakthroughs have been made in systemic treatment for HCC over the past two decades, which have improved treatment outcomes. In addition to multiple tyrosine kinase inhibitors (mTKIs), immune checkpoint inhibitors (ICIs) and antiangiogenic drugs are increasingly being applied. The combination of ICI and antiangiogenic or dual ICIs has become the new standard of care due to remarkable response rates. However, currently available systemic regimens are primarily reserved for certain patients in the intermediate and advanced stages who will not benefit from locoregional treatments. Evidence supporting the use of systemic treatment as neoadjuvant or adjuvant therapies in patients with early-stage HCC, especially the high risk of recurrence after curative treatments, remains limited. This review identified recent developments in systemic therapy, including mTKIs and ICIs, considering results on first- and second-line treatment, role of neoadjuvant and adjuvant settings, and combination with loco-regional therapy. Various ongoing clinical trials regarding the role of systemic therapies and potential novel targets in patients with early-, intermediate-, and advanced-stage HCC were also summarized and revealed that systemic therapy is no longer limited to advanced-stage HCC. Moreover, the introduction of T-cell redirecting strategies, including bispecific antibodies and chimeric antigen receptor T cells, has revolutionized the treatment landscape for HCC. Future research should focus on an in-depth exploration of the mechanisms governing the establishment of tumor barriers.
|
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] | 2024-11-20 | 1 |
39561966
|
[
"systemic treatment",
"systemic therapies",
"systemic therapy",
"curative treatments",
"locoregional treatments",
"treatment outcomes",
"HCC",
"chimeric antigen receptor T cells",
"multiple tyrosine kinase inhibitors",
"immune checkpoint inhibitors",
"certain patients",
"patients",
"advanced-stage HCC",
"Various ongoing clinical trials",
"antiangiogenic drugs",
"remarkable response rates",
"potential novel targets",
"ICI",
"ICIs",
"early-stage HCC",
"bispecific antibodies",
"neoadjuvant or adjuvant therapies",
"role",
"recent developments",
"second-line treatment",
"Future research",
"tumor barriers",
"currently available systemic regimens",
"combination",
"T-cell redirecting strategies"
] |
[
"Hepatocellular carcinoma",
"Immune checkpoint inhibitors",
"Tyrosine kinase inhibitors",
"neoadjuvant therapy"
] | 0 |
10.1016/j.bj.2024.100815
|
[
"Teng",
"Wu",
"Lin"
] |
[
"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Liver Research Unit, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan. Electronic address: b101090023@gmail.com.",
"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan. Electronic address: lesliewu902@gmail.com.",
"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: lsmpaicyto@gmail.com."
] |
[
"39561966"
] |
[] | 10.948066 | 3.951205 |
39561867
| 232 |
Treatment of two pediatric patients with refractory systemic lupus erythematosus using CD19-targeted CAR T-cells.
|
Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising strategy for treating autoimmune diseases, particularly in systemic lupus erythematosus (SLE). However, CAR T-cell therapy for pediatric patients with SLE remains unexplored. Herein, we present a compelling investigation of two pediatric patients with refractory SLE who underwent infusion of CD19-targeted CAR T-cells. Patients 1 and 2 tolerated the CAR T-cell therapy well, which demonstrated remarkable efficacy after five and four months, respectively.
|
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] | 2024-11-20 | 1 |
39561867
|
[
"pediatric patients",
"refractory SLE",
"CAR T-cell therapy",
"Patients",
"SLE",
"systemic lupus erythematosus",
"autoimmune diseases",
"Chimeric antigen receptor",
"CAR) T-cell therapy",
"the CAR T-cell therapy",
"remarkable efficacy",
"CD19-targeted CAR T-cells",
"two pediatric patients",
"infusion",
"a promising strategy",
"a compelling investigation",
"five and four months",
"1",
"two",
"we",
"which",
"who"
] |
[
"Autoimmune disorders",
"Chimeric antigen receptor",
"Lupus nephritis",
"Pediatrics",
"Systemic lupus erythematosus"
] | 0 |
10.1016/j.autrev.2024.103692
|
[
"He",
"Hu",
"Zhang",
"Liu",
"Li",
"Zheng",
"Shen",
"Yang",
"Wang",
"Ma",
"Qian",
"Lu",
"Mao"
] |
[
"Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China.",
"Department of Allergy Immunology and Rheumatology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China.",
"Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China.",
"Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China.",
"Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China.",
"Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China.",
"Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China.",
"Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China.",
"Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China.",
"Perioperative and Systems Medicine Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China; Division of Anesthetics, Pain Medicine & Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom.",
"Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. Electronic address: cqian@precision-biotech.com.",
"Department of Allergy Immunology and Rheumatology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China. Electronic address: meipinglu@zju.edu.cn.",
"Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China. Electronic address: maojh88@zju.edu.cn."
] |
[
"39561867"
] |
[] | 7.291987 | 4.562156 |
39561735
| 233 |
Survivorship in Chimeric Antigen Receptor T-Cell Therapy Recipients: Infections, Secondary Malignancies, and Non-Relapse Mortality.
|
Chimeric antigen receptor (CAR) T-cell therapy has significantly advanced the treatment of hematologic malignancies, offering curative potential for patients with relapsed or refractory disease. However, the long-term survivorship of these patients is marked by unique challenges, particularly immune deficits and infectious complications, second primary malignancies (SPMs), and non-relapse mortality (NRM). Understanding and addressing these risks is paramount to improving patient outcomes and quality of life.
This review explores the incidence and risk factors for NRM and long-term complications following CAR T-cell therapy. Infections are the leading cause of NRM, accounting for over 50% of cases, driven by neutropenia, hypogammaglobulinemia, and impaired cellular immunity. SPMs, including secondary myeloid and T-cell malignancies, are increasingly recognized, prompting the FDA to issue a black box warning, although their direct link to CAR T cells remains disputed. While CAR T-cell-specific toxicities like cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome contribute to morbidity, they represent only a minority of NRM cases. The management of these complications is critical as CAR T-cell therapy is being evaluated for broader use, including in earlier treatment lines and for non-malignant conditions like autoimmune diseases.
CAR T-cell therapy has revolutionized cancer treatment, but survivorship is complicated by infections, SPMs, and ultimately endangered by NRM. Prophylactic strategies, close monitoring, and toxicity management strategies are key to improving long-term outcomes.
|
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] | 2024-11-20 | 1 |
39561735
|
[
"CAR T cells",
"NRM cases",
"CAR T-cell therapy",
"non-malignant conditions",
"NRM",
"non-relapse mortality",
"second primary malignancies",
"toxicity management strategies",
"earlier treatment lines",
"hematologic malignancies",
"cancer treatment",
"T-cell malignancies",
"infectious complications",
"patient outcomes",
"CAR T-cell-specific toxicities",
"CAR) T-cell therapy",
"cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome",
"impaired cellular immunity",
"SPMs",
"patients",
"curative potential",
"Prophylactic strategies",
"unique challenges",
"autoimmune diseases",
"close monitoring",
"long-term complications",
"broader use",
"survivorship",
"cases",
"Chimeric antigen receptor"
] |
[
"Chimeric antigen receptor T",
"Chimeric antigen receptor T-cell therapy",
"Infections",
"Non-relapse mortality",
"Secondary primary malignancies"
] | 0 |
10.1159/000542631
|
[
"Tix",
"Subklewe",
"von Bergwelt-Baildon",
"Rejeski"
] |
[
"Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Munich, Germany, tobias.tix@med.uni-muenchen.de.",
"Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Munich, Germany.\nGerman Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany.",
"Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Munich, Germany.\nGerman Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany.",
"Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Munich, Germany.\nGerman Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany.\nAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
] |
[
"39561735"
] |
[] | 6.18821 | 4.192312 |
39561045
| 234 |
Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells.
|
Regenerative medicine is a rapidly expanding field harnessing human pluripotent stem cell (hPSC)-derived cells and tissues to treat many diseases, including type 1 diabetes. However, graft immune protection remains a key challenge. Chimeric antigen receptor (CAR) technology confers new specificities to effector T cells and immunosuppressive regulatory T cells (Tregs). One challenge in CAR design is identifying target molecules unique to the cells of interest. Here, we employ combinatorial genetic engineering to confer CAR-Treg-mediated localized immune protection to stem cell-derived cells. We engineered hPSCs to express truncated epidermal growth factor receptor (EGFRt), a biologically inert and generalizable target for CAR-Treg homing and activation, and generated CAR-Tregs recognizing EGFRt. Strikingly, CAR-Tregs suppressed innate and adaptive immune responses in vitro and prevented EGFRt-hPSC-derived pancreatic beta-like cell (sBC [stem cell-derived beta cell]) graft immune destruction in vivo. Collectively, we provide proof of concept that hPSCs and Tregs can be co-engineered to protect hPSC-derived cells from immune rejection upon transplantation.
|
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] | 2024-11-19 | 60 |
39561045
|
[
"human pluripotent stem cell",
"hPSC)-derived cells",
"graft immune protection",
"cell-derived cells",
"immune rejection",
"CAR",
"truncated epidermal growth factor receptor",
"target molecules",
"Chimeric antigen receptor",
"immunosuppressive regulatory T cells",
"EGFRt",
"combinatorial genetic engineering",
"effector T cells",
"many diseases",
"sBC [stem cell-derived beta cell]) graft immune destruction",
"CAR-Treg-mediated localized immune protection",
"new specificities",
"innate and adaptive immune responses",
"CAR-Treg homing",
"CAR design",
"Regenerative medicine",
"Tregs",
"the cells",
"CAR-Tregs",
"hPSC-derived cells",
"concept",
"proof",
"CAR) technology",
"EGFRt-hPSC-derived pancreatic beta-like cell",
"tissues"
] |
[
"CAR-Treg",
"CP: Stem cell research",
"autoimmunity",
"cell replacement therapy",
"chimeric antigen receptor",
"immune tolerance",
"regenerative medicine",
"regulatory T cell",
"stem cell-derived beta cell",
"transplantation",
"type 1 diabetes"
] | 0 |
10.1016/j.celrep.2024.114994
10.5966/sctm.2015-0329
10.1111/ajt.14169
10.1002/phar.2716
10.1210/er.2015-1084
10.3389/fimmu.2012.00051
10.1146/annurev-immunol-042718-041717
10.1038/s41577-019-0232-6
10.1126/scitranslmed.aad4134
10.1126/scitranslmed.abo2628
10.3389/fimmu.2022.1075813
10.1084/jem.20040180
10.1016/j.transproceed.2013.01.073
10.1038/s41573-019-0051-2
10.1158/2159-8290.CD-12-0548
10.1038/s41571-023-00754-1
10.3389/fimmu.2018.02359
10.1038/s41573-019-0041-4
10.1172/JCI82771
10.3389/fimmu.2021.686439
10.1172/JCI168601
10.3389/fimmu.2023.1207108
10.2337/diacare.26.3.832
10.1097/MOT.0000000000000546
10.3390/biom12060810
10.3389/fendo.2021.707881
10.3389/fendo.2022.989815
10.1007/s00125-011-2379-y
10.1172/JCI109665
10.1002/cti2.1135
10.1093/intimm/dxq440
10.1073/pnas.0914500107
10.1038/362248a0
10.1016/S1674-8301(10)60043-7
10.4161/isl.24249
10.1097/TP.0000000000004709
10.1016/j.cell.2019.05.043
10.1073/pnas.1902566116
10.1038/s41587-023-01784-x
10.1038/s41587-019-0016-3
10.1016/j.stem.2020.02.006
10.1016/j.molmet.2023.101809
10.1172/jci.insight.167215
10.3389/fimmu.2022.934343
10.3390/ijms17071000
10.1111/imr.12172
10.1016/j.stem.2014.05.018
10.1084/jem.20060772
10.1084/jem.20060468
10.1126/scitranslmed.aaz3866
10.1002/eji.201141651
10.3791/404
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10.1038/s41598-020-72821-x
|
[
"Barra",
"Robino",
"Castro-Gutierrez",
"Proia",
"Russ",
"Ferreira"
] |
[
"Diabetes Institute, University of Florida, Gainesville, FL 32610, USA; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA.",
"Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.",
"Diabetes Institute, University of Florida, Gainesville, FL 32610, USA; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA.",
"Diabetes Institute, University of Florida, Gainesville, FL 32610, USA; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA.",
"Diabetes Institute, University of Florida, Gainesville, FL 32610, USA; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA. Electronic address: holger.russ@ufl.edu.",
"Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: ferreirl@musc.edu."
] |
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[] | 8.937828 | 3.662762 |
39559715
| 235 |
A novel mitochondrial pyruvate carrier inhibitor drives stem cell-like memory CAR T cell generation and enhances antitumor efficacy.
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Adoptive cell transfer with chimeric antigen receptor (CAR)-expressing T cells can induce remarkable complete responses in cancer patients. Therapeutic success has been correlated with central and stem cell-like memory T cell subsets in the infusion product, which are better able to drive efficient CAR T cell
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39559715
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"cancer patients",
"Therapeutic success",
"T cells",
"the infusion product",
"which"
] |
[
"CAR T cell manufacture",
"CAR T cell therapy",
"MT: Regular Issue",
"immunometabolism",
"memory T cell differentiation",
"mitochondrial pyruvate carrier"
] | 0 |
10.1016/j.omton.2024.200897
10.1056/NEJMoa2210859
10.1056/NEJMoa1709919
10.1056/NEJMoa2210233
10.1126/science.1129003
10.1038/s41591-018-0010-1
10.1172/JCI125423
10.1182/blood-2014-01-552174
10.1126/sciadv.abj2820
10.1158/2159-8290.CD-20-1677
10.1126/science.abb9847
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10.1038/s43018-021-00207-7
10.1016/s1074-7613(02)00323-0
10.1016/j.immuni.2011.09.021
10.1038/s41586-023-06546-y
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10.1016/j.cell.2016.05.035
10.1016/j.cell.2015.03.021
10.1016/j.cmet.2022.03.013
10.1126/science.1218099
10.1126/science.1218530
10.1042/bj1480085
10.1002/anie.201914391
10.1016/j.molmet.2022.101469
10.1021/acs.jmedchem.0c01570
10.1016/j.chembiol.2021.03.005
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10.1177/096032719101000405
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10.1038/s41423-020-0365-3
10.1038/s41571-023-00754-1
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10.1038/nature08155
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10.1038/ncb3575
10.1172/JCI24480
10.1073/pnas.0307298101
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10.1016/j.cmet.2020.11.007
|
[
"Wenes",
"Lepez",
"Arinkin",
"Maundrell",
"Barabas",
"Simonetta",
"Dutoit",
"Romero",
"Martinou",
"Migliorini"
] |
[
"AGORA Cancer Research Center, 1005 Lausanne, Switzerland.\nSwiss Cancer Center Léman, Geneva, Lausanne, Switzerland.\nCenter for Translational Research in Onco-Hematology, University of Geneva, 1206 Geneva, Switzerland.\nMPC Therapeutics, 1206 Geneva, Switzerland.",
"AGORA Cancer Research Center, 1005 Lausanne, Switzerland.\nSwiss Cancer Center Léman, Geneva, Lausanne, Switzerland.\nCenter for Translational Research in Onco-Hematology, University of Geneva, 1206 Geneva, Switzerland.",
"Department of Molecular and Cellular Biology, University of Geneva, 1206 Geneva, Switzerland.",
"MPC Therapeutics, 1206 Geneva, Switzerland.\nDepartment of Molecular and Cellular Biology, University of Geneva, 1206 Geneva, Switzerland.",
"Department of Molecular and Cellular Biology, University of Geneva, 1206 Geneva, Switzerland.",
"Center for Translational Research in Onco-Hematology, University of Geneva, 1206 Geneva, Switzerland.\nDivision of Hematology, Department of Oncology, Geneva University Hospitals (HUG), 1206 Geneva, Switzerland.",
"AGORA Cancer Research Center, 1005 Lausanne, Switzerland.\nSwiss Cancer Center Léman, Geneva, Lausanne, Switzerland.\nCenter for Translational Research in Onco-Hematology, University of Geneva, 1206 Geneva, Switzerland.",
"Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.\nNovigenix SA, 1066 Epalinges, Switzerland.",
"MPC Therapeutics, 1206 Geneva, Switzerland.\nDepartment of Molecular and Cellular Biology, University of Geneva, 1206 Geneva, Switzerland.",
"AGORA Cancer Research Center, 1005 Lausanne, Switzerland.\nSwiss Cancer Center Léman, Geneva, Lausanne, Switzerland.\nCenter for Translational Research in Onco-Hematology, University of Geneva, 1206 Geneva, Switzerland.\nDepartment of Oncology, Geneva University Hospitals (HUG), 1206 Geneva, Switzerland."
] |
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[] | 8.262893 | 4.233355 |
39558776
| 236 |
Are we there yet? CAR-T therapy in multiple myeloma.
|
The last few years have seen a revolution in cellular immunotherapies for multiple myeloma (MM) with novel antigen targets. The principle new target is B-cell maturation antigen (BCMA). Autologous chimeric antigen receptor T-cell (CAR-T) therapy directed against BCMA was first approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2021, although approval by the National Institute for Health and Care Excellent (NICE) is awaited. Initial response rates in patients with heavily pretreated MM have been impressive, but patients are still relapsing. Furthermore, CAR-T manufacturing is expensive and time-consuming, and T-cell fitness is impaired by prior MM treatment. Numerous strategies to improve outcomes and delivery of cellular immunotherapy are under investigation, including next-generation CARs, allogeneic 'off-the-shelf' CARs and targeting of other MM antigens including G protein-coupled receptor, class C, group 5, member D (GPRC5D), Fc receptor homologue 5 (FcRH5), cluster of differentiation (CD)19, signalling lymphocyte activation molecule family member 7 (SLAMF7) and several others. In this exciting and rapidly evolving treatment landscape, this review evaluates the most recent clinical and preclinical data pertaining to these new cellular immunotherapies and explores strategies to overcome resistance pathways. On the protracted journey to a long-term cure, we outline the challenges that lie ahead and ask, 'Are we there yet?'
|
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39558776
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10.1002/ajh.26486
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10.1111/bjh.18816
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|
[
"Mirvis",
"Benjamin"
] |
[
"School of Cancer & Pharmaceutical Sciences, King's College London, London, UK.\nDepartment of Haematology, King's College Hospital NHS Foundation Trust, London, UK.",
"School of Cancer & Pharmaceutical Sciences, King's College London, London, UK.\nDepartment of Haematology, King's College Hospital NHS Foundation Trust, London, UK."
] |
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[] | 4.866487 | 6.227926 |
39558141
| 237 |
Ablation of FAS confers allogeneic CD3
|
Allogeneic chimaeric antigen receptor T cells (allo-CAR T cells) derived from healthy donors could provide rapid access to standardized and affordable batches of therapeutic cells if their rejection by the host's immune system is avoided. Here, by means of an in vivo genome-wide CRISPR knockout screen, we show that the deletion of Fas or B2m in allo- T cells increases their survival in immunocompetent mice. Human B2M
|
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] | 2024-11-19 | 42 |
39558141
|
[
"T cells",
"Allogeneic chimaeric antigen receptor T cells",
"therapeutic cells",
"Human B2",
"rapid access",
"healthy donors",
"B2",
"allo-CAR T cells",
"immunocompetent mice",
"Fas",
"CRISPR",
"standardized and affordable batches",
"an in vivo genome-wide CRISPR knockout screen",
"means",
"Allogeneic",
"M",
"the hosts immune system",
"the deletion",
"their rejection",
"their survival",
"we"
] |
[] | 0 |
10.1038/s41551-024-01282-8
10.1126/science.1853205
10.1038/349329a0
10.1016/j.immuni.2006.06.013
10.1038/s41568-020-00323-z
10.1056/NEJMoa1709866
10.1038/s41573-019-0051-2
10.1038/s41467-019-13007-6
10.1038/nature21405
10.1182/blood-2012-01-405365
10.1182/bloodadvances.2017012823
10.1158/0008-5472.CAN-14-3321
10.3389/fimmu.2021.744823
10.1038/s41577-020-00457-z
10.1038/s41586-019-1821-z
10.1016/j.cell.2019.07.044
10.1126/sciimmunol.abe8219
10.1016/j.omtn.2023.04.017
10.1084/jem.20191166
10.1016/j.cell.2020.03.039
10.1016/j.ccell.2022.06.001
10.1016/j.cell.2023.08.013
10.1126/science.abn5647
10.1158/2159-8290.CD-19-0813
10.1038/nbt.2800
10.1186/s13059-014-0554-4
10.1016/j.smim.2006.03.003
10.1158/2159-8290.CD-22-1350
10.1056/NEJMoa2300709
10.3324/haematol.2020.254045
10.1038/nbt.3860
10.1038/35869
10.1038/s41587-020-0601-5
10.1080/2162402X.2015.1054597
10.1182/blood.V85.4.1043.bloodjournal8541043
10.1038/s41418-023-01229-7
10.18632/oncotarget.15218
10.1172/JCI121491
10.1038/356314a0
10.1146/annurev.iy.09.040191.001331
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10.1007/s12026-009-8136-3
10.1089/crispr.2018.0014
|
[
"Menegatti",
"Lopez-Cobo",
"Sutra Del Galy",
"Fuentealba",
"Silva",
"Perrin",
"Heurtebise-Chrétien",
"Pottez-Jouatte",
"Darbois",
"Burgdorf",
"Privat",
"Simon",
"Laprie-Sentenac",
"Saitakis",
"Wick",
"Webber",
"Moriarity",
"Lantz",
"Amigorena",
"Menger"
] |
[
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.\nCellAction (Cell therapy Acceleration and Innovation), Institut Curie, Suresnes, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.\nCellAction (Cell therapy Acceleration and Innovation), Institut Curie, Suresnes, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.\nCellAction (Cell therapy Acceleration and Innovation), Institut Curie, Suresnes, France.",
"Gustave Roussy, Paris-Saclay University, INSERM U1015, Villejuif, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.\nCellAction (Cell therapy Acceleration and Innovation), Institut Curie, Suresnes, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.\nCellAction (Cell therapy Acceleration and Innovation), Institut Curie, Suresnes, France.",
"Gustave Roussy, Paris-Saclay University, INSERM U1015, Villejuif, France.",
"Gustave Roussy, Paris-Saclay University, INSERM U1015, Villejuif, France.",
"Mnemo Therapeutics, Paris, France.",
"Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.\nMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.\nCenter for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.",
"Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.\nMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.\nCenter for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.",
"Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.\nMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.\nCenter for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France.",
"Immunity and Cancer, Institut Curie, PSL University, INSERM U932, Paris, France. sebastian.amigorena@curie.fr.\nCellAction (Cell therapy Acceleration and Innovation), Institut Curie, Suresnes, France. sebastian.amigorena@curie.fr.\nMnemo Therapeutics, Paris, France. sebastian.amigorena@curie.fr.",
"Gustave Roussy, Paris-Saclay University, INSERM U1015, Villejuif, France. Laurie.MENGER@gustaveroussy.fr."
] |
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[] | 8.1294 | 3.381858 |
39557825
| 238 |
Improved safety of chimeric antigen receptor T cells indirectly targeting antigens via switchable adapters.
|
Chimeric antigen receptor T (CAR-T) cells show remarkable efficacy for some hematological malignancies. However, CAR targets that are expressed at high level and selective to tumors are scarce. Several strategies have been proposed to tackle the on-target off-tumor toxicity of CAR-T cells that arise from suboptimal selectivity, but these are complicated, with many involving dual gene expression for specificity. In this study, we show that switchable CAR-T cells with a tumor targeting adaptor can mitigate on-target off-tumor toxicity against a low selectivity tumor antigen that cannot be targeted by conventional CAR-T cells, such as CD40. Our system is composed of anti-cotinine murine CAR-T cells and cotinine-labeled anti-CD40 single chain variable fragments (scFv), with which we show selective tumor killing while sparing CD40-expressing normal cells including macrophages in a mouse model of lymphoma. Simple replacement of the tumor-targeting adaptor with a suicidal drug-conjugated tag may further enhance safety by enabling permanent in vivo depletion of the switchable CAR-T cells when necessary. In summary, our switchable CAR system can control CAR-T cell toxicity while maintaining therapeutic efficacy, thereby expanding the range of CAR targets.
|
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] | 2024-11-19 | 75 |
39557825
|
[
"selective tumor killing",
"CAR targets",
"anti-cotinine murine CAR-T cells",
"tumor",
"tumors",
"switchable CAR-T cells",
"CAR-T cell toxicity",
"conventional CAR-T cells",
"CAR-T cells",
"CAR",
"target",
"dual gene expression",
"remarkable efficacy",
"suboptimal selectivity",
"therapeutic efficacy",
"the switchable CAR-T cells",
"cotinine-labeled anti-CD40 single chain variable fragments",
"a low selectivity tumor antigen",
"a tumor targeting adaptor",
"vivo depletion",
"high level",
"Chimeric antigen receptor T (CAR-T) cells",
"our switchable CAR system",
"Several strategies",
"CD40",
"macrophages",
"the tumor-targeting adaptor",
"Simple replacement",
"safety",
"scFv"
] |
[] | 0 |
10.1038/s41467-024-53996-7
|
[
"Park",
"Kim",
"Kim",
"Kim",
"Oh",
"Kang",
"Lee",
"Hwang",
"Lee",
"Lee",
"Park",
"Lee",
"Jeong",
"Lee",
"Youn",
"Choi",
"Son",
"Chung",
"Chung",
"Choi"
] |
[
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.\nCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"AbTis Co. Ltd., Suwon, Gyeonggi-do, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"AbTis Co. Ltd., Suwon, Gyeonggi-do, Republic of Korea.\nDepartment of Biopharmaceutical Convergence, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.",
"Department of Biopharmaceutical Convergence, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.\nTicaros Inc., Seoul, Republic of Korea.",
"Department of Medical Science, AMIST, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.",
"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.\nDepartment of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Republic of Korea.",
"Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.\nInstitute of Human Environment Interface Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.",
"Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.",
"Department of Biopharmaceutical Convergence, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea. sjchung@skku.edu.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. jjhchung@snu.ac.kr.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. jjhchung@snu.ac.kr.\nCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. jjhchung@snu.ac.kr.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. khchoi@snu.ac.kr.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. khchoi@snu.ac.kr.\nCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. khchoi@snu.ac.kr."
] |
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] |
[] | 8.600892 | 5.014929 |
39557820
| 239 |
Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors.
|
The redirection of T lymphocytes against tumor-associated or tumor-specific antigens, using bispecific antibodies or chimeric antigen receptors (CAR), has shown therapeutic success against certain hematological malignancies. However, this strategy has not been effective against solid tumors. Here, we describe the development of CAR T cells targeting p95HER2, a tumor-specific antigen found in HER2-amplified solid tumors. These CAR T cells display robust activity against p95HER2-expressing cell lines but demonstrate limited efficacy against patient-derived xenografts. As p95HER2 is invariably detectable on tumor cells that overexpress HER2, but not those that express HER2 at normal levels, we arm p95HER2-specific CAR T cells with affinity-tuned bispecific antibodies against HER2 and CD3 in order to redirect them only to HER2-amplified cells. The combination of p95HER2.CAR T cells and HER2 x CD3 bispecific antibodies lead to a complete regression in three HER2-positive, patient-derived mouse xenografts tumor models. This combination represents a promising strategy to redirect T cells against a subset of HER2-positive tumors.
|
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] | 2024-11-19 | 26 |
39557820
|
[
"tumor cells",
"CAR T cells",
"T cells",
"p95HER2.CAR T cells",
"solid tumors",
"HER2",
"p95HER2-specific CAR T cells",
"chimeric antigen receptors",
"HER2-amplified solid tumors",
"HER2-amplified cells",
"These CAR T cells",
"bispecific antibodies",
"HER2-positive tumors",
"therapeutic success",
"p95HER2-expressing cell lines",
"certain hematological malignancies",
"mouse xenografts",
"limited efficacy",
"normal levels",
"robust activity",
"tumor-associated or tumor-specific antigens",
"three HER2-positive, patient-derived mouse xenografts tumor models",
"a tumor-specific antigen",
"CAR",
"CD3",
"patient-derived xenografts",
"p95HER2",
"T",
"order",
"HER2 x CD3 bispecific"
] |
[] | 0 |
10.1038/s41467-024-53265-7
|
[
"Román Alonso",
"Grinyó-Escuer",
"Duro-Sánchez",
"Rius-Ruiz",
"Bort-Brusca",
"Escorihuela",
"Maqueda-Marcos",
"Pérez-Ramos",
"Gago",
"Nogales",
"Espinosa-Bravo",
"Peg",
"Escrivá-de-Romaní",
"Foradada",
"Soucek",
"Braña",
"Galvao",
"Martín-Lluesma",
"Moessner",
"Klein",
"Garralda",
"Saura",
"Arribas"
] |
[
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.\nCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Monforte de Lemos, Madrid, 28029, Spain.\nDepartment of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.\nCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Monforte de Lemos, Madrid, 28029, Spain.\nDepartment of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.\nCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Monforte de Lemos, Madrid, 28029, Spain.\nDepartment of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.\nCancer Research Program, Hospital del Mar Research Institute, Barcelona, 08003, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.",
"Cancer Research Program, Hospital del Mar Research Institute, Barcelona, 08003, Spain.\nDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, 08002, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.\nCancer Research Program, Hospital del Mar Research Institute, Barcelona, 08003, Spain.",
"Cancer Research Program, Hospital del Mar Research Institute, Barcelona, 08003, Spain.",
"Breast Surgical Unit, Breast Cancer Center, Gynecology Department, Vall d'Hebron University Hospital, Barcelona, 08035, Spain.",
"Surgical Pathology, Anatomical Pathology, Clinical Laboratories, Vall d'Hebron University Hospital, Barcelona, 08035, Spain.",
"Medical Oncology Service, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, 08035, Spain.",
"Peptomyc S.L, Barcelona, 08035, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.\nDepartment of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.\nInstitució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010, Spain.",
"Medical Oncology Service, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, 08035, Spain.",
"Medical Oncology Service, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, 08035, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain.\nDepartamento de Ciencias Médicas Básicas, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, 28668, Spain.",
"Roche Innovation Center Zurich, Roche Pharma Research and Early Development, Schlieren, 8952, Switzerland.",
"Roche Innovation Center Zurich, Roche Pharma Research and Early Development, Schlieren, 8952, Switzerland.",
"Medical Oncology Service, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, 08035, Spain.",
"Medical Oncology Service, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, 08035, Spain.",
"Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, 08035, Spain. jarribas@researchmar.net.\nCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Monforte de Lemos, Madrid, 28029, Spain. jarribas@researchmar.net.\nCancer Research Program, Hospital del Mar Research Institute, Barcelona, 08003, Spain. jarribas@researchmar.net.\nDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, 08002, Spain. jarribas@researchmar.net.\nInstitució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010, Spain. jarribas@researchmar.net."
] |
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[] | 9.150043 | 5.312608 |
39554121
| 240 |
Antigen-specific T cell immunotherapy by in vivo mRNA delivery.
|
Immunotherapy has shown promise for treating patients with autoimmune diseases or cancer, yet treatment is associated with adverse effects associated with global activation or suppression of T cell immunity. Here, we developed antigen-presenting nanoparticles (APNs) to selectively engineer disease antigen (Ag)-specific T cells by
|
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] | 2024-11-18 | 72 |
39554121
|
[
"disease antigen",
"autoimmune diseases",
"T cell immunity",
"global activation",
"adverse effects",
"patients",
"cancer",
"suppression",
"treatment",
"promise",
"(Ag)-specific T cells",
"antigen-presenting nanoparticles",
"APNs",
"Immunotherapy",
"we"
] |
[] | 0 |
10.1101/2024.10.29.620946
|
[
"Su",
"Siebart",
"Chan",
"Wang",
"Yao",
"Trenkle",
"Sivakumar",
"Su",
"Harandi",
"Shahrawat",
"Nguyen",
"Goenka",
"Mun",
"Dhodapkar",
"Kwong"
] |
[
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.\nDepartment of Hematology/Oncology, Emory University, Atlanta, Georgia.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.",
"Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.\nDepartment of Hematology/Oncology, Emory University, Atlanta, Georgia.",
"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.\nWinship Cancer Institute of Emory University, Atlanta, GA 30322, USA.\nInstitute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA.\nParker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.\nIntegrated Cancer Research Center, Georgia Institute of Technology, Atlanta, GA 30332, USA.\nGeorgia Immunoengineering Consortium, Emory University and Georgia Institute of Technology, Atlanta, GA 30332, USA."
] |
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[] | 10.038857 | 3.80118 |
39551607
| 241 |
Inhibition of Cbl-b restores effector functions of human intratumoral NK cells.
|
T cell-based immunotherapies including immune checkpoint blockade and chimeric antigen receptor T cells can induce durable responses in patients with cancer. However, clinical efficacy is limited due to the ability of cancer cells to evade immune surveillance. While T cells have been the primary focus of immunotherapy, recent research has highlighted the importance of natural killer (NK) cells in directly recognizing and eliminating tumor cells and playing a key role in the set-up of an effective adaptive immune response. The remarkable potential of NK cells for cancer immunotherapy is demonstrated by their ability to broadly identify stressed cells, irrespective of the presence of neoantigens, and their ability to fight tumors that have lost their major histocompatibility complex class I (MHC I) expression due to acquired resistance mechanisms.However, like T cells, NK cells can become dysfunctional within the tumor microenvironment. Strategies to enhance and reinvigorate NK cell activity hold potential for bolstering cancer immunotherapy.
In this study, we conducted a high-throughput screen to identify molecules that could enhance primary human NK cell function. After compound validation, we investigated the effect of the top performing compounds on dysfunctional NK cells that were generated by a newly developed in vitro platform. Functional activity of NK cells was investigated using compounds alone and in combination with checkpoint inhibitor blockade. The findings were validated on patient-derived intratumoral dysfunctional NK cells from different cancer types.
The screening approach led to the identification of a Casitas B-lineage lymphoma (Cbl-b) inhibitor enhancing the activity of primary human NK cells. Furthermore, the Cbl-b inhibitor was able to reinvigorate the activity of in vitro generated and patient-derived dysfunctional NK cells. Finally, Cbl-b inhibition combined with T-cell immunoreceptor with Ig and ITIM domains (TIGIT) blockade further increased the cytotoxic potential and reinvigoration of both in vitro generated and patient-derived intratumoral dysfunctional NK cells.
These findings underscore the relevance of Cbl-b inhibition in overcoming NK cell dysfunctionality with the potential to complement existing immunotherapies and improve outcomes for patients with cancer.
|
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] | 2024-11-18 | 55 |
39551607
|
[
"dysfunctional NK cells",
"NK cells",
"NK cell activity",
"NK cell dysfunctionality",
"primary human NK cells",
"cancer cells",
"T cells",
"tumor cells",
"primary human NK cell function",
"stressed cells",
"patient-derived intratumoral dysfunctional NK cells",
"cancer immunotherapy",
"NK",
"T cell-based immunotherapies",
"immune checkpoint blockade",
"checkpoint inhibitor blockade",
"generated and patient-derived intratumoral dysfunctional NK cells",
"existing immunotherapies",
"T-cell immunoreceptor",
"immunotherapy",
"different cancer types",
"cancer",
"patients",
"Functional activity",
"immune surveillance",
"tumors",
"acquired resistance mechanisms",
"chimeric antigen receptor",
"in vitro generated and patient-derived dysfunctional NK cells",
"natural killer (NK) cells"
] |
[
"Immune Checkpoint Inhibitor",
"Immunotherapy",
"Intratumoral",
"Natural Killer - NK"
] | 0 |
10.1136/jitc-2024-009860
10.1056/NEJMoa2109970
10.1016/S1470-2045(22)00226-1
10.1016/j.cell.2023.03.006
10.1056/NEJMoa1414428
10.1056/NEJMoa1910836
10.1056/NEJMoa1910231
10.3389/fimmu.2021.636568
10.1158/2159-8290.CD-17-0593
10.1016/j.ccell.2020.03.017
10.1038/s41423-019-0206-4
10.1038/s41577-022-00732-1
10.1038/s41586-023-06945-1
10.1046/j.1365-3083.2002.01053.x
10.1038/s41591-018-0085-8
10.1158/2326-6066.CIR-18-0062
10.1158/2326-6066.CIR-18-0500
10.1038/s41598-020-65666-x
10.1158/2159-8290.CD-20-0655
10.1038/35003228
10.1038/s41392-020-00421-2
10.1084/jem.180.4.1395
10.1038/ni1487
10.1038/srep37996
10.1038/nature12998
10.1136/jitc-2020-001688
10.1073/pnas.92.19.8705
10.1158/1078-0432.CCR-12-3603
10.1093/nar/gkac1000
10.1038/s41590-018-0132-0
10.1016/j.cell.2018.10.014
10.1016/j.intimp.2015.09.017
10.1016/j.intimp.2020.106198
10.1007/s00262-020-02558-z
10.1158/0008-5472.CAN-10-4179
10.1136/jitc-2020-001054
10.3389/fimmu.2022.997806
10.1016/j.cell.2020.02.041
10.4049/jimmunol.168.9.4531
10.4049/jimmunol.175.3.1636
10.1093/intimm/dxl046
10.1136/jitc-2021-003385
10.1084/jem.20020068
10.1084/jem.20021686
10.4049/jimmunol.2000177
10.1038/35003235
10.1038/ni0901-870
10.1002/eji.201948204
10.3389/fimmu.2020.564133
10.1126/science.1103478
10.1038/s41420-022-00953-2
10.3389/fimmu.2019.00014
10.1080/2162402X.2014.1001224
10.1186/1479-5876-11-307
10.1038/s41467-024-44789-z
10.1200/JCO.2022.40.16_suppl.TPS2691
10.1186/2051-1426-3-S2-P175
|
[
"Tundo",
"Trefny",
"Rodić",
"Grueninger",
"Brodmann",
"Börsch",
"Serger",
"Fürst",
"Buchi",
"Buczak",
"Müller",
"Sach-Peltason",
"Don",
"Herzig",
"Lardinois",
"Heinzelmann-Schwarz",
"Mertz",
"Hojski",
"Schaeuble",
"Laubli",
"Natoli",
"Toso",
"Luu",
"Zippelius",
"Romagnani"
] |
[
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.\nRoche Innovation Center, F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Roche Innovation Center, F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development, Basel, Switzerland.",
"Roche Innovation Center, F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development, Basel, Switzerland.",
"Department of Biomedicine, Bioinformatics Core Facility, University of Basel, Basel, Switzerland.\nSwiss Institute of Bioinformatics, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Biozentrum, Proteomics Core Facility, University of Basel, Basel, Switzerland.",
"Roche Innovation Center, F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development, Basel, Switzerland.",
"Roche Innovation Center, F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Department of Thoracic Surgery, University Hospital Basel, Basel, Switzerland.",
"Department of Gynecology and Obstetrics, University Hospital Basel, Basel, Switzerland.",
"Institute of Pathology, Cantonal Hospital Basel-Landschaft, Liestal, Switzerland.",
"Department of Thoracic Surgery, University Hospital Basel, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Medical Oncology, University Hospital Basel, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Roche Innovation Center, F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland.",
"Department of Biomedicine, University Hospital Basel, Basel, Switzerland alfred.zippelius@usb.ch andrea.romagnani@roche.com.\nMedical Oncology, University Hospital Basel, Basel, Switzerland.",
"Roche Innovation Center, F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development, Basel, Switzerland alfred.zippelius@usb.ch andrea.romagnani@roche.com."
] |
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] |
[] | 11.089738 | 5.205162 |
39551605
| 242 |
Afatinib boosts CAR-T cell antitumor therapeutic efficacy via metabolism and fate reprogramming.
|
Chimeric antigen receptor T (CAR-T) cell therapy has been shown remarkable efficacy in the treatment of hematological malignancies in recent years. However, a considerable proportion of patients would experience tumor recurrence and deterioration. Insufficient CAR-T cell persistence is the major reason for relapse. Multiple strategies to enhance the long-term antitumor effects of CAR-T cells have been explored and developed. In this study, we focused on tyrosine kinase inhibitors (TKIs), which have emerged immunomodulatory potential besides direct tumoricidal effects.
Here, we screened 50 approved TKIs drugs and identified that afatinib (AFA) markedly enhanced the expressing of CD62L and inhibited reactive oxygen species level in T cells. And the underlying mechanisms of AFA medicating T cells were explored by detecting signal transduction, and metabolism pattern. Furthermore, we co-cultured AFA with CAR-T cells during the preparation stage and multianalyses of differentiation characteristics, metabolic profiling, and RNA sequencing revealed that AFA induce comprehensive metabolism remodeling and fate reprogramming. Based on it, we finally identified the antitumor efficacy of AFA-pretreatment CAR-T compared with negative-control CAR-T.
We identified that AFA blocked the T-cell receptor (TCR) and phosphoinositide 3-kinase-protein kinase B-mechanistic target of rapamycin signaling pathways, induced metabolic reprogramming and modulated T-cell differentiation. When combined with CAR-T cells, AFA inhibited the exhaustion and enhanced the persistence and cytotoxicity. Our results revealed that the pretreatment of AFA enables to boost CAR-T cells with strong antitumor cytotoxicity in leukemia mouse model.
Our study systematically demonstrated that AFA pretreatment effectively enhanced CAR-T cells antitumor performance, which presents a novel optimization strategy for potent and durable CAR-T cell therapy.
|
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] | 2024-11-18 | 38 |
39551605
|
[
"T cells",
"Insufficient CAR-T cell persistence",
"CAR-T cells",
"tyrosine kinase inhibitors",
"T-cell differentiation",
"AFA",
"potent and durable CAR-T cell therapy",
"strong antitumor cytotoxicity",
"comprehensive metabolism remodeling",
"remarkable efficacy",
"metabolic profiling",
"-cultured AFA",
"direct tumoricidal effects",
"rapamycin signaling pathways",
"tumor recurrence",
"metabolism pattern",
"differentiation characteristics",
"immunomodulatory potential",
"hematological malignancies",
"Multiple strategies",
"the T-cell receptor",
"AFA-pretreatment CAR-T",
"leukemia mouse model",
"signal transduction",
"CAR-T",
"cytotoxicity",
"recent years",
"patients",
"fate reprogramming",
"negative-control CAR"
] |
[
"Adoptive cell therapy - ACT",
"Chimeric antigen receptor - CAR",
"Hematologic Malignancies"
] | 0 |
10.1136/jitc-2024-009949
10.1038/s41408-022-00688-4
10.1186/s13045-020-00953-8
10.3389/fimmu.2020.569117
10.1038/s41375-020-01056-6
10.1186/s40364-020-00197-1
10.1038/s41591-018-0010-1
10.1038/s41467-020-20696-x
10.3389/fimmu.2020.01217
10.1016/j.ctrv.2022.102479
10.1126/sciimmunol.abq3016
10.4049/jimmunol.1901213
10.1016/j.bbcan.2023.188967
10.1158/1078-0432.CCR-21-0452
10.1182/blood.2019002121
10.1038/nri1330
10.1042/BJ20130485
10.1182/blood-2007-08-108050
10.3389/fimmu.2021.718621
10.1186/s13045-022-01255-x
10.3389/fimmu.2017.01516
10.1126/science.aak9776
10.1186/s12967-021-03165-x
10.1186/s13045-015-0214-5
10.1038/s43018-021-00207-7
10.1186/s13045-023-01504-7
10.1172/JCI150807
10.1002/ajh.25505
10.1182/blood.2021011597
10.1186/s13045-022-01244-0
10.1016/j.cmet.2023.12.010
10.1186/s12916-021-02161-8
10.1097/BS9.0000000000000165
10.1038/s41586-022-04431-8
10.1186/s40364-022-00434-9
10.1126/sciimmunol.aav6473
10.1016/j.celrep.2015.10.072
10.3389/fonc.2021.723888
|
[
"Dai",
"Liu",
"An",
"Zhong",
"Zhang",
"Lou"
] |
[
"Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, Chongqing, China.\nMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, Chongqing, China.",
"Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, Chongqing, China.\nState Key Laboratory of Trauma and Chemical Poisoning, Chongqing Key Clinical Specialty, Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, Chongqing, China.",
"Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, Chongqing, China.\nState Key Laboratory of Trauma and Chemical Poisoning, Chongqing Key Clinical Specialty, Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, Chongqing, China.",
"Department of Gynecology and Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.",
"Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, Chongqing, China 300326@hospital.cqmu.edu.cn zhangxxi@sina.com.\nState Key Laboratory of Trauma and Chemical Poisoning, Chongqing Key Clinical Specialty, Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, Chongqing, China.\nJinfeng Laboratory, Chongqing, Chongqing, China.",
"Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, Chongqing, China 300326@hospital.cqmu.edu.cn zhangxxi@sina.com."
] |
[
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] |
[] | 7.16646 | 7.003715 |
39551173
| 243 |
Ectopic expression of NKG7 enhances CAR-T function and improves the therapeutic efficacy in liquid and solid tumors.
|
Lack of biopsies after treatment, especially in solid tumors, restricts the understanding of chimeric antigen receptor (CAR)-T cells -related characteristic in vivo, thus hindering the development of strategies to improve CAR-T cells efficacy. Here, we applied nineteen individual single-cell RNA sequencing (scRNA-seq) data from clinical samples of digestive cancers to explore the characteristics of tumor-infiltrating T cells (TILs) to identify effective targets which might be benefit for enhancing the function of CAR-T cells. The data showed that natural killer cell granule protein 7 (NKG7) was overexpressed in TILs and positively associated with anti-PD1 or anti-CTLA4 therapy in digestive cancers. Subsequently, we found that ectopic expression of NKG7 significantly improved the cytotoxicity of B7H3-targeting CAR-T cells to B7H3-positive digestive cancer cells (MKN45, Huh7, HuCCT-1, SW620 and PANC-1 cells), as well as promoted the TNF-α and IL-2 expression. Furthermore, in a CD19-targeting CAR-T model, the therapeutic efficacy was also found increased after NKG7 overexpression. Mechanically, NKG7 preserved surface CAR expression and promoted CAR-T cell proliferation after exposing to relative tumor antigen. These results indicated that it may be feasible to explore single-cell sequencing data of clinical tumor samples to find strategies to improve CAR-T function, and that ectopic expression of NKG7 is an effective strategy to improve the therapeutic efficacy of CAR-T cells against tumors.
|
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] | 2024-11-18 | 1 |
39551173
|
[
"CAR)-T cells",
"PANC-1 cells",
"natural killer cell granule protein",
"clinical tumor samples",
"CAR-T cells efficacy",
"CAR-T cell proliferation",
"relative tumor antigen",
"tumor-infiltrating T cells",
"CAR-T cells",
"solid tumors",
"digestive cancers",
"CAR",
"B7H3-positive digestive cancer cells",
"single-cell sequencing data",
"NKG7 overexpression",
"NKG7",
"tumors",
"ectopic expression",
"anti-CTLA4 therapy",
"anti-CTLA4",
"clinical samples",
"B7H3-targeting CAR-T cells",
"anti-PD1",
"chimeric antigen receptor",
"CAR-T function",
"effective targets",
"strategies",
"nineteen individual single-cell RNA",
"TILs",
"treatment"
] |
[
"CAR-T",
"Hematologic malignancies",
"IL-2 signaling pathway",
"Immunotherapy",
"Solid tumors"
] | 0 |
10.1016/j.phrs.2024.107506
|
[
"Chen",
"Wang",
"Huang",
"Han",
"Cai",
"Xu",
"Sun",
"Chen",
"Chen",
"Yu",
"Du",
"Li",
"Zheng",
"Ma",
"Wang"
] |
[
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; The first Clinical Medical School, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Department of Human Anatomy, Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.",
"Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China. Electronic address: jnzheng@xzhmu.edu.cn.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China. Electronic address: boma@xzhmu.edu.cn.",
"Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China. Electronic address: wangg@xzhmu.edu.cn."
] |
[
"39551173"
] |
[] | 10.207476 | 6.079487 |
39548827
| 244 |
Clinical significance of complete remission and measurable residual disease in relapsed/refractory multiple myeloma patients treated with T-cell redirecting immunotherapy.
|
The impact of measurable residual disease (MRD) in relapse/refractory multiple myeloma (RRMM) patients treated with T-cell redirecting immunotherapy is uncertain. We analyzed MRD dynamics using next-generation flow in 201 patients treated in clinical trials with chimeric antigen receptor (CAR) T cells and T-cell engagers (TCE). Achieving MRD negativity at 10
|
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] | 2024-11-16 | 41 |
39548827
|
[
"T cells",
"MRD dynamics",
"MRD negativity",
"measurable residual disease",
"MRD",
"chimeric antigen receptor",
"clinical trials",
"T-cell redirecting immunotherapy",
"T-cell engagers",
"CAR",
"next-generation flow",
"relapse/refractory multiple myeloma (RRMM) patients",
"TCE",
"201 patients",
"The impact",
"10",
"201",
"We"
] |
[] | 0 |
10.1002/ajh.27526
10.1056/NEJMOA2204591
10.1016/S0140-6736(21)00933-8
10.1056/nejmoa2024850
10.1016/S1470-2045(23)00222-X
10.1038/s41591-023-02528-9
10.1056/NEJMOA2203478
10.1056/NEJMOA22136114
10.1056/NEJMOA2303379/SUPPL_FILE/NEJMOA2303379_DATA-SHARING.PDF
10.1016/S2352-3026(23)00236-3
10.1182/BLOOD.2020010439
10.1182/BLOOD.2022016782
10.3324/haematol.2018.194282
10.1038/S41408-023-00797-8
10.1016/J.CLML.2019.09.623
10.1038/S41375-020-0711-6
10.3324/HAEMATOL.2023.283073
10.1182/BLOODADVANCES.2020002827
10.1158/2643-3230.BCD-23-0044
10.1016/S1470-2045(16)30206-6
10.1200/JCO.19.01231
10.1038/SJ.LEU.2404284
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10.1038/S41375-018-0329-0
10.1038/S41408-023-00820-Y
10.1016/J.CLML.2019.09.622
10.1016/J.CLML.2023.02.005
10.1182/BLOOD-2018-06-858613
10.1182/BLOOD.2020006731
10.1200/JCO.22.02567/SUPPL_FILE/PROTOCOL_JCO.22.02567.PDF
10.1200/JCO.23.01696
10.1200/JCO.23.02232
10.1038/S41591-023-02491-5
10.1038/s43018-023-00625-9
|
[
"Zabaleta",
"Puig",
"Cedena",
"Oliver-Caldes",
"Perez",
"Moreno",
"Tamariz-Amador",
"Rodriguez-Otero",
"Prosper",
"Gonzalez-Calle",
"López-Corral",
"Rey-Búa",
"Puertas",
"Mirás",
"Sánchez-Pina",
"López-Muñoz",
"Juan",
"González-Navarro",
"Urbano",
"de Larrea",
"Blade",
"Lahuerta",
"Martinez-Lopez",
"Mateos",
"San Miguel",
"Paiva"
] |
[
"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Servicio de Hematología y Hemoterapia, Hospital 12 de Octubre, Madrid, Spain.",
"Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain.",
"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain.",
"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain.",
"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Servicio de Hematología y Hemoterapia, Hospital 12 de Octubre, Madrid, Spain.",
"Servicio de Hematología y Hemoterapia, Hospital 12 de Octubre, Madrid, Spain.",
"Servicio de Hematología y Hemoterapia, Hospital 12 de Octubre, Madrid, Spain.",
"Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.",
"Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.",
"Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.",
"Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.",
"Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Servicio de Hematología y Hemoterapia, Hospital 12 de Octubre, Madrid, Spain.",
"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain.",
"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain.",
"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain."
] |
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[] | 5.10944 | 6.098326 |
39548594
| 245 |
Persistence of activated anti-mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas.
|
Patients with advanced gastric and colorectal cancers have limited treatment options. Since mesothelin is highly expressed in these tumour types, we evaluated the therapeutic benefits of anti-mesothelin hYP218 CAR T cells alone, and in combination with anti-PD1 antibody, pembrolizumab. GEPIA analysis was performed using human gastric (n = 408) and colon cancer tumours (n = 275) in TCGA database, to evaluate mRNA expression of mesothelin, compared to normal tissues. Mesothelin expression in gastric and colorectal cancer cell-lines (n = 5) was analysed using flow cytometry. In vitro efficacy by hYP218 CAR T cells was tested by cytotoxicity and cytokine release assays. In vivo anti-tumour efficacy of hYP218 CAR T cells alone, and in combination with pembrolizumab, was evaluated in NSG mice bearing human gastric (HGC27) and colorectal (SW48) tumour xenografts. Additionally, hYP218 CAR-T cell persistence, activation and exhaustion marker-expression were studied. Mesothelin expression was significantly higher in gastric and colon cancer biopsies compared to normal tissues (p < .005). Mesothelin expression in gastric and colon cancer cell lines ranged from 10 000 to 70 000 molecules per cell. hYP218 CAR T cells demonstrated strong cytotoxic activity at low effector to target ratio, ranging from 0.24 to 1.0. In NSG mouse-models, hYP218 CAR T cells demonstrated anti-tumour efficacy and persisted in the tumour microenvironment in a functional state at day 40 posttreatment with expression of activation markers CD39 and CD69, increased production of IFN-γ and TNF-α and ability to kill tumour cells in vitro when isolated from tumours. There was increased PD1 expression. In combination with pembrolizumab, hYP218 CAR T cells led to slower tumour growth in NSG mice bearing large but not small HGC27 tumours. Anti-tumour efficacy of hYP218 CAR T cells is due to increased accumulation of activated CAR T cells in the tumour and combination with pembrolizumab resulted in improvement in anti-tumour activity of large established tumours. HIGHLIGHTS: Mesothelin expression is significantly higher in gastric and colorectal cancers than normal tissues. hYP218 CAR T cells demonstrate strong anti-tumour activity against mesothelin-positive gastric and colorectal carcinomas. Activated hYP218 CAR T cells persist in the tumour microenvironment and retain their cytotoxic activity. Addition of pembrolizumab in larger tumours enhance CAR T cell efficacy.
|
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] | 2024-11-16 | 56 |
39548594
|
[
"hYP218 CAR T cells",
"CAR T cell efficacy",
"tumour cells",
"activated CAR T cells",
"anti-mesothelin hYP218 CAR T cells",
"Activated hYP218 CAR T cells",
"anti-tumour activity",
"colon cancer tumours",
"cell",
"Anti-tumour efficacy",
"anti-tumour efficacy",
"strong anti-tumour activity",
"vivo anti-tumour efficacy",
"colorectal cancers",
"larger tumours",
"large established tumours",
"anti-PD1 antibody",
"tumours",
"hYP218 CAR-T cell persistence",
"increased PD1 expression",
"Mesothelin expression",
"gastric and colon cancer cell lines",
"mRNA expression",
"expression",
"tumour growth",
"strong cytotoxic activity",
"colorectal carcinomas",
"NSG mice",
"gastric and colorectal cancer cell-lines",
"human gastric"
] |
[
"CAR T cell",
"anti‐PD1",
"colorectal cancer",
"gastric cancer",
"mesothelin",
"pembrolizumab",
"xenograft cancer model"
] | 0 |
10.1002/ctm2.70057
10.1016/s0140-6736(20)31288-5
10.3390/cancers14071732
10.1016/S0140-6736(19)32319-0
10.1016/j.bbcan.2021.188615
10.3322/caac.21657
10.1001/jama.2021.0106
10.1038/s41573-021-00189-2
10.3389/fimmu.2018.02593
10.3389/fimmu.2018.02740
10.1111/imr.13273
10.1158/1078-0432.CCR-03-0801
10.1002/cncr.33145
10.1158/1078-0432.CCR-07-0869
10.1158/1078-0432.CCR-14-0804
10.1200/jco.19.02085
10.1158/1078-0432.CCR-19-0070
10.1016/j.ymthe.2019.07.015
10.1158/2159-8290.Cd-21-0407
10.2217/imt.16.4
10.18632/oncotarget.3429
10.18632/oncotarget.15814
10.1200/JCO.2023.41.4_suppl.245
10.3892/ol.2020.11290
10.1016/j.adcanc.2023.100098
10.1158/1535-7163.Mct-22-0073
10.1186/s40064-015-1509-2
10.1200/JCO.2016.68.3672
10.1038/bjc.2012.235
10.4049/jimmunol.178.7.4650
10.1158/2326-6066.Cir-20-0270
10.4049/jimmunol.2400151
10.1172/jci.insight.133977
10.3748/wjg.v25.i38.5773
10.1158/2326-6066.Cir-13-0006
10.1158/2326-6066.Cir-13-0170
10.3390/biomedicines9040397
10.4132/jptm.2016.11.18
10.1038/s41419-019-1711-1
10.1016/j.omto.2021.02.013
10.1038/s41419-020-2450-z
10.1186/s12967-024-04982-6
10.7150/ijbs.64630
10.1016/j.ymthe.2021.01.021
10.1016/j.labinv.2023.100303
10.1038/s42003-023-04978-w
10.1038/s41591-023-02452-y
10.1038/s41423-021-00749-x
10.1016/j.ymthe.2017.05.012
10.1016/j.ebiom.2019.01.029
10.1038/s41467-023-37785-2
10.1158/2159-8290.CD-15-0583
10.1016/j.ymthe.2023.06.006
|
[
"Mir",
"Venugopalan",
"Zhang",
"Nair",
"Sengupta",
"Khanal",
"Stathopoulou",
"Jiang",
"Hassan"
] |
[
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Cancer Data Science Laboratory, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.",
"Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA."
] |
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[] | 9.720415 | 5.974189 |
39548510
| 246 |
Efficacy and safety of novel multiple-chain DAP-CAR-T cells targeting mesothelin in ovarian cancer and mesothelioma: a single-arm, open-label and first-in-human study.
|
Despite remarkable achievements in applying chimeric antigen receptor (CAR)-T cells to treat hematological malignancies, they remain much less effective against solid tumors, facing several challenges affecting their clinical use. We previously showed that multichain DNAX-activating protein (DAP) CAR structures could enhance the safety and efficacy of CAR-T cells when used against solid tumors. In particular, mesothelin (MSLN)-targeted CAR-T cell therapy has therapeutic potential in MSLN-positive solid tumors, including ovarian cancer and mesothelioma.
In vitro cell killing assays and xenograft model were utilized to determine the anti-tumor efficacy of MSLN targeting DAP-CAR-T cells and other CAR-T cells. ELISA and flow cytometry analysis were used to assess the cytokine secretion capacity and proliferation ability. Eight patients with MSLN expression were enrolled to evaluate the safety and efficacy of MSLN-DAP CAR-T cell therapy. Single-cell sequencing was performed to explore the dynamics of immune cells in patients during treatment and to identify the transcriptomic signatures associated with efficacy and toxicity.
We found that multichain DAP-CAR formed by combining a natural killer cell immunoglobulin-like receptor truncator and DAP12 exhibited better cytotoxicity and tumor-killing capacity than other natural killer cell-activated receptors associated with DAP12, DAP10, or CD3Z. The safety and efficacy of MSLN-DAP CAR-T cell therapy in patients with ovarian cancer and mesothelioma were evaluated in a single-arm, open-label clinical trial (ChiCTR2100046544); two patients achieved partial response, while four patients had a stable disease status. Furthermore, single-cell sequencing analysis indicated that KT032 CAR-T cell infusion could recruit more immune cells and temporarily remodel the TME.
Our study highlights the safety and therapeutic efficacy of multiple-chain DAP-CAR-T cell therapy targeting MSLN to treat patients with ovarian cancer and mesothelioma.
ChiCTR.org.cn, ChiCTR2100046544 . May 21, 2021.
|
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] | 2024-11-16 | 34 |
39548510
|
[
"immune cells",
"more immune cells",
"KT032 CAR-T cell infusion",
"therapeutic efficacy",
"CAR-T cells",
"solid tumors",
"MSLN-DAP CAR-T cell therapy",
"other natural killer cell-activated receptors",
"efficacy",
"MSLN expression",
"patients",
"other CAR-T cells",
"MSLN",
"chimeric antigen receptor",
"single-cell sequencing analysis",
"mesothelin (MSLN)-targeted CAR-T cell therapy",
"DAP-CAR-T cells",
"ovarian cancer",
"multichain DAP-CAR",
"vitro cell killing assays",
"DAP) CAR structures",
"multiple-chain DAP-CAR-T cell therapy",
"a natural killer cell immunoglobulin-like receptor truncator",
"MSLN-positive solid tumors",
"(CAR)-T cells",
"therapeutic potential",
"several challenges",
"xenograft model",
"the anti-tumor efficacy",
"better cytotoxicity"
] |
[
"CAR-T cells",
"Efficacy",
"MSLN",
"Mesothelioma",
"Ovarian cancer",
"Safety"
] | 0 |
10.1186/s13073-024-01405-5
|
[
"Xu",
"Tian",
"Wang",
"Chen",
"Zuo",
"Zhou",
"Bai",
"Zhao",
"Fu",
"Sun",
"Wang",
"Zhu",
"Zhang",
"Wang",
"Sun",
"Shu"
] |
[
"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People's Republic of China. tongpeng_xu_njmu@163.com.",
"Department of Geriatric Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.",
"Nanjing CART Medical Technology Co., Ltd, Nanjing, 210032, People's Republic of China.",
"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.",
"Department of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.",
"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.\nDepartment of Oncology, Gusu School, Suzhou Municipal Hospital, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People's Republic of China.",
"Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.",
"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.",
"The Second Affiliated Hospitalof , Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.",
"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.",
"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.",
"Department of Oncology, Xishan People's Hospital of Wuxi City, Wuxi, People's Republic of China.",
"Nanjing CART Medical Technology Co., Ltd, Nanjing, 210032, People's Republic of China.",
"Nanjing CART Medical Technology Co., Ltd, Nanjing, 210032, People's Republic of China. wangenxiu@cart-med.com.",
"Suzhou Cancer Center Core Laboratory, Gusu School, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215001, People's Republic of China. sunming348@hotmail.com.",
"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People's Republic of China. shuyongqian@csco.org.cn."
] |
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[] | 9.779565 | 5.976088 |
39548270
| 247 |
Allogeneic chimeric antigen receptor cell therapies for cancer: progress made and remaining roadblocks.
|
Chimeric antigen receptor (CAR) T cells are revolutionizing cancer therapy, particularly for haematological malignancies, conferring durable and sometimes curative responses in patients with advanced-stage disease. The CAR T cell products currently approved for clinical use are all autologous and are often effective; however, in patients who are lymphopenic and/or heavily pretreated with chemotherapy, autologous T cells can be difficult to harvest in sufficient numbers or have functional impairments that might ultimately render them less efficacious. Moreover, autologous products take several weeks to produce, and each product can be used in only one patient. By contrast, allogeneic CAR T cells can be produced for many patients using T cells from a single healthy donor, can be optimized for safety and efficacy, can be instantly available for 'off-the-shelf' use and, therefore, might also be more cost-effective. Despite these potential advantages, the development of allogeneic CAR T cells has lagged behind that of autologous products, owing to the additional challenges such as avoiding graft-versus-host disease and host-mediated graft rejection. Over the past few years, the development of advanced genome-editing techniques has facilitated the generation of novel allogeneic CAR T cell products. Furthermore, CAR cell products derived from other cell types such as induced pluripotent stem cells and natural killer cells are being investigated for clinical use. In this Review, we discuss the potential of allogeneic CAR cell products to expand life-saving immunotherapy to a much broader population of patients in the coming years, the progress made to date and strategies to overcome remaining hurdles.
|
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39548270
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[
"Diorio",
"Teachey",
"Grupp"
] |
[
"Division of Oncology and Center for Childhood Cancer Research, Department of Paediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.\nSusan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Division of Oncology and Center for Childhood Cancer Research, Department of Paediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.\nSusan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Division of Oncology and Center for Childhood Cancer Research, Department of Paediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. GRUPP@chop.edu.\nSusan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, Philadelphia, PA, USA. GRUPP@chop.edu."
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[] | 8.259924 | 3.311512 |
39546589
| 248 |
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity.
|
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an immune checkpoint that has critical roles in immune exhaustion. However, little is known about the mechanisms that regulate TIM-3 surface expression and turnover. Here, we report that human TIM-3 is palmitoylated by the palmitoyltransferase DHHC9 at residue cysteine 296 (Cys
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] | 2024-11-15 | 1 |
39546589
|
[
"TIM-3 surface expression",
"human TIM-3",
"TIM-3",
"T cell immunoglobulin",
"immune exhaustion",
"critical roles",
"residue cysteine",
"DHHC9",
"domain-containing protein",
"Cys",
"turnover",
"an immune checkpoint",
"the palmitoyltransferase",
"the mechanisms",
"296",
"3",
"that",
"we"
] |
[] | 0 |
10.1126/sciimmunol.adp7302
|
[
"Zhang",
"Ren",
"Xiao",
"Ma",
"Liu",
"Dou",
"Fan",
"Wang",
"Zhan",
"Gao",
"Yue",
"Li",
"Gao",
"Liang",
"Wu",
"Ma"
] |
[
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Department of Hepatology, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 250012 Jinan, Shandong, China.",
"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Department of Cellular Biology, School of Basic Medical Sciences, Shandong University, 250012 Jinan, China.",
"Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Shandong University, 250012 Jinan, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.",
"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.\nSchool and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong, China."
] |
[
"39546589"
] |
[] | 33.048912 | 7.572611 |
39542653
| 249 |
DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2
|
Neoadjuvant therapy with trastuzumab, pertuzumab and paclitaxel (THP) has significantly improved the prognosis of patients with human epidermal growth factor receptor 2 (HER2)
The Cancer Genome Atlas database, Gene Expression Omnibus and membrane protein database were used to identify the key regulator of THP neoadjuvant resistance. The biological functions and mechanisms of delta-like 4 proteins (DLL4) in THP therapy resistance were investigated in vitro and in vivo using the bioinformatic analysis, multiplex immunofluorescence, flow cytometry, sphere formation assays and chromatin immunoprecipitation, etc. Furthermore, DLL4-targeted chimeric antigen receptor (CAR)-T cells were established to sensitize THP therapy.
DLL4 was identified as a key target in THP neoadjuvant therapy resistance for HER2
Our study revealed novel functions of DLL4 in cell stemness and immune infiltration, including NET formation and T cell exclusion, which collectively contributed to THP neoadjuvant therapy resistance in HER2
|
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] | 2024-11-15 | 49 |
39542653
|
[
"THP neoadjuvant therapy resistance",
"THP therapy resistance",
"THP neoadjuvant resistance",
"THP therapy",
"Neoadjuvant therapy",
"THP",
"membrane protein database",
"T cell exclusion",
"sphere formation assays",
"CAR)-T cells",
"human epidermal growth factor receptor",
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"DLL4",
"Gene Expression Omnibus",
"novel functions",
"flow cytometry",
"multiplex immunofluorescence",
"DLL4-targeted chimeric antigen receptor",
"HER2",
"cell stemness and immune infiltration",
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"The Cancer Genome Atlas database",
"NET",
"patients",
"vivo",
"paclitaxel",
"pertuzumab",
"(THP",
"mechanisms",
"trastuzumab"
] |
[
"Breast Cancer",
"Chemotherapy",
"Immunotherapy",
"Stem Cell"
] | 0 |
10.1136/jitc-2024-009636
10.3109/07357907.2010.496759
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10.1126/science.3798106
10.1016/s0960-9776(02)00273-4
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10.1056/NEJMoa1113216
10.1016/S1470-2045(18)30570-9
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10.1056/NEJMoa1413513
10.1016/S1470-2045(13)70130-X
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10.1073/pnas.1014835108
10.2147/OTT.S244860
10.1152/physrev.00005.2017
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10.1016/j.biopha.2023.115383
10.1016/j.canlet.2019.07.012
10.1038/s41392-024-01828-x
10.1101/gad.342287.120
10.1038/sj.bjc.6604484
10.1158/1535-7163.MCT-12-0640
10.1016/S0070-2153(10)92009-7
10.1016/j.pan.2018.09.014
10.1002/cam4.962
10.2147/OTT.S150565
10.1177/0960327116650006
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10.2353/ajpath.2010.090908
10.1007/s12032-014-0945-0
10.1016/j.humpath.2014.04.025
10.3389/fonc.2023.1114621
10.1038/s41568-021-00366-w
10.1016/j.biopha.2023.116043
10.1186/s12943-023-01748-4
10.1038/nmeth.3337
10.15252/emmm.201910681
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10.1016/j.arcmed.2019.12.019
10.1016/j.yexcr.2013.01.010
10.1158/0008-5472.CAN-14-3773
10.1007/s10585-019-09973-2
10.1093/cvr/cvv151
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|
[
"Yan",
"Xie",
"Liu",
"Yang",
"Zhou"
] |
[
"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.",
"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.",
"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.",
"Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China zhoutianxing@tjmuch.com tjyangyf@126.com.\nKey Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.",
"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China zhoutianxing@tjmuch.com tjyangyf@126.com."
] |
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[] | 9.430197 | 5.791115 |
39542025
| 250 |
Engineered receptors for soluble cellular communication and disease sensing.
|
Despite recent advances in mammalian synthetic biology, there remains a lack of modular synthetic receptors that can robustly respond to soluble ligands and, in turn, activate bespoke cellular functions. Such receptors would have extensive clinical potential to regulate the activity of engineered therapeutic cells, but so far only receptors against cell-surface targets have approached clinical translation
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39542025
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"a lack",
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[] | 0 |
10.1038/s41586-024-08366-0
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|
[
"Piraner",
"Abedi",
"Duran Gonzalez",
"Chazin-Gray",
"Lin",
"Zhu",
"Ravindran",
"Schlichthaerle",
"Huang",
"Bearchild",
"Lee",
"Wyman",
"Jun",
"Baker",
"Roybal"
] |
[
"Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.",
"Department of Biochemistry, University of Washington, Seattle, WA, USA.",
"Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.",
"Department of Biochemistry, University of Washington, Seattle, WA, USA.",
"Joint Graduate Program in Bioengineering, University of California San Francisco and University of California Berkeley, San Francisco, CA, USA.",
"Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.",
"Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.\nPenn Medical Scientist Training Program, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Biochemistry, University of Washington, Seattle, WA, USA.",
"Department of Biochemistry, University of Washington, Seattle, WA, USA.",
"Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.",
"Department of Biochemistry, University of Washington, Seattle, WA, USA.",
"Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.",
"Department of Otolaryngology, University of California San Francisco, San Francisco, CA, USA.\nDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.\nHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.",
"Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.\nInstitute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.\nGraduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.\nHoward Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.",
"Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. kole.roybal@ucsf.edu.\nParker Institute for Cancer Immunotherapy, San Francisco, CA, USA. kole.roybal@ucsf.edu.\nChan Zuckerberg Biohub, San Francisco, CA, USA. kole.roybal@ucsf.edu.\nGladstone UCSF Institute for Genetic Immunology, San Francisco, CA, USA. kole.roybal@ucsf.edu.\nUCSF Cell Design Institute, San Francisco, CA, USA. kole.roybal@ucsf.edu."
] |
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[] | 9.254512 | 4.524243 |
39541577
| 251 |
Building the future management of follicular lymphoma with T-cell-redirecting strategies.
|
Follicular lymphoma (FL) usually requires multiple lines of therapy, and disease control remains largely insufficient with conventional chemoimmunotherapy. Several T-cell-redirecting strategies recently approved in the relapsed/refractory setting have the potential to improve outcomes and change the treatment algorithm in FL. This review focuses on the role of chimeric antigen receptor T cells and bispecific antibodies in FL, paying special attention to sequencing approaches and future directions.
|
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] | 2024-11-14 | 1 |
39541577
|
[
"chimeric antigen receptor T cells",
"FL",
"disease control",
"special attention",
"multiple lines",
"bispecific antibodies",
"conventional chemoimmunotherapy",
"future directions",
"Follicular lymphoma",
"therapy",
"outcomes",
"approaches",
"Several T-cell-redirecting strategies",
"the relapsed/refractory setting",
"the treatment algorithm",
"the potential",
"the role",
"This review"
] |
[] | 0 |
10.1182/blood.2024025699
|
[
"Iacoboni",
"Morschhauser"
] |
[
"Department of Hematology, Vall d'Hebron University Hospital, Experimental Hematology, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.",
"Department of Hematology, Centre Hospitalier Universitaire de Lille, Groupe de Recherche sur les Formes Injectables et les Technologies Associées, Lille, France."
] |
[
"39541577"
] |
[] | 6.18255 | 6.357968 |
39539554
| 252 |
Oncolytic virus and CAR-T cell therapy in solid tumors.
|
Adoptive immunotherapy with T cells, genetically modified to express a tumor-reactive chimeric antigen receptor (CAR), is an innovative and rapidly developing life-saving treatment for cancer patients without other therapeutic opportunities. CAR-T cell therapy has proven effective only in hematological malignancies. However, although by now only a few clinical trials had promising outcomes, we predict that CAR-T therapy will eventually become an established treatment for several solid tumors. Oncolytic viruses (OVs) can selectively replicate in and kill cancer cells without harming healthy cells. They can stimulate an immune response against the tumor, because OVs potentially stimulate adaptive immunity and innate components of the host immune system. Using CAR-T cells along with oncolytic viruses may enhance the efficacy of CAR-T cell therapy in destroying solid tumors by increasing the tumor penetrance of T cells and reducing the immune suppression by the tumor microenvironment. This review describes recent advances in the design of oncolytic viruses and CAR-T cells while providing an overview of the potential combination of oncolytic virotherapy with CAR-T cells for solid cancers. In this review, we will focus on the host-virus interaction in the tumor microenvironment to reverse local immunosuppression and to develop CAR-T cell effector function.
|
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39539554
|
[
"T cells",
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"healthy cells",
"solid tumors",
"several solid tumors",
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"CAR-T cell effector function",
"CAR-T cells",
"solid cancers",
"oncolytic virotherapy",
"cancer patients",
"CAR-T therapy",
"CAR",
"other therapeutic opportunities",
"adaptive immunity",
"recent advances",
"local immunosuppression",
"the tumor microenvironment",
"the tumor penetrance",
"hematological malignancies",
"a tumor-reactive chimeric antigen receptor",
"the host immune system",
"Adoptive immunotherapy",
"outcomes",
"components",
"OVs",
"the tumor",
"the host-virus interaction"
] |
[
"CAR T cells",
"cancer",
"immunotherapy",
"oncolytic viruses",
"solid tumor"
] | 0 |
10.3389/fimmu.2024.1455163
10.1038/s41568-018-0006-7
10.1038/nrc.2017.17
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|
[
"Ponterio",
"Haas",
"De Maria"
] |
[
"Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.\nDipartimento di Medicina e Chirurgia Traslazionali, Sezione di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy.",
"Dipartimento di Medicina e Chirurgia Traslazionali, Sezione di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy.\nIIGM - Italian Institute for Genomic Medicine, Candiolo, TO, Italy.",
"Dipartimento di Medicina e Chirurgia Traslazionali, Sezione di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy.\nFondazione Policlinico Universitario \"A. Gemelli\" - I.R.C.C.S., Rome, Italy."
] |
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[] | 10.079265 | 3.958939 |
39539024
| 253 |
Establishment of potent TCR-T cells specific for cisplatin-resistance related tumor-associated antigen, CLSPN using codon-optimization.
|
Adoptive T cell therapy, using T cell receptor-engineered T (TCR-T) cells and chimeric antigen receptor T (CAR-T) cells, is a potent immunotherapy option. Bladder cancer is a prevalent urological malignancy, particularly in cases of muscle invasion and metastasis, for which systemic therapy is crucial. Immunotherapy utilizing immune checkpoint blockade has been approved for bladder cancer treatment. The antitumor effect of an immune checkpoint blockade based on cytotoxic T cells (CTLs) and the patient's immune status is essential. The chemotherapeutic drug cisplatin (CDDP) is a key drug in bladder cancer treatment. However, it has been shown to suppress T cells, making combination therapy with CDDP and immunotherapy difficult. To address this, we developed TCR-T cells specific for bladder cancer cells. In previous studies, we found that the tumor-associated antigen CLSPN is overexpressed in CDDP-resistant bladder cancer cells and that the antigenic peptide HLA-A*02:01/CLSPN
|
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] | 2024-11-14 | 39 |
39539024
|
[
"bladder cancer cells",
"T cells",
"Adoptive T cell therapy",
"cytotoxic T cells",
"Bladder cancer",
"bladder cancer treatment",
"immune checkpoint blockade",
"CDDP-resistant bladder cancer cells",
"systemic therapy",
"combination therapy",
"TCR-T cells",
"muscle invasion",
"Immunotherapy",
"immunotherapy",
"CDDP",
"T cell receptor-engineered T (TCR-T) cells and chimeric antigen receptor T (CAR-T) cells",
"CLSPN",
"an immune checkpoint blockade",
"previous studies",
"metastasis",
"cases",
"CTLs",
"a potent immunotherapy option",
"a prevalent urological malignancy",
"The chemotherapeutic drug cisplatin",
"the patients immune status",
"the tumor-associated antigen",
"a key drug",
"HLA-A*02:01/CLSPN",
"(CDDP"
] |
[
"CLSPN",
"TCR-T",
"Urothelial carcinoma",
"cisplatin resistance",
"immunotherapy"
] | 0 |
10.1080/21645515.2024.2414542
10.1038/s41571-023-00744-3
10.1016/S0022-5347(17)42494-3
10.1200/JCO.2000.18.17.3068
10.1200/JCO.2005.07.757
10.1016/j.annonc.2021.11.012
10.2147/ITT.S202006
10.1186/s12967-023-03944-8
10.3389/fonc.2023.1114203
10.1158/1078-0432.CCR-06-0595
10.1007/s00262-021-03032-0
10.1056/NEJMoa1613683
10.1056/NEJMoa2035807
10.1111/cas.12830
10.1007/s00262-023-03388-5
10.1007/s00428-021-03239-7
10.1016/j.bbrc.2019.11.107
10.1158/0008-5472.CAN-09-1450
10.1111/j.1365-2567.2009.03227.x
10.1182/blood-2011-04-346338
10.3390/cells10092379
10.7554/eLife.53244
10.4049/jimmunol.1401717
10.1002/path.6083
10.1007/s00262-021-03025-z
10.1186/s12575-023-00201-6
10.3389/fimmu.2022.835762
10.1158/1535-7163.MCT-07-0092
10.1158/1078-0432.CCR-0620-3
10.1158/1078-0432.CCR-07-4590
10.1056/NEJMoa2312117
10.3389/fimmu.2014.00194
10.3233/BLC-180167
10.1038/nature12965
10.1016/j.immuni.2013.07.012
10.1016/j.xcrm.2024.101393
10.1038/s41467-020-19288-6
10.3390/cancers13153666
10.1126/sciadv.abm8780
|
[
"Hori",
"Yamada",
"Murata",
"Miyata",
"Mizue",
"Murai",
"Minowa",
"Sasaki",
"Shijubou",
"Kubo",
"Morita",
"Tokita",
"Kanaseki",
"Tsukahara",
"Abe",
"Shinohara",
"Hirohashi",
"Torigoe"
] |
[
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.\nDepartment of Renal and Genitourinary surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.\nDepartment of Renal and Genitourinary surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Renal and Genitourinary surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.\nDepartment of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Renal and Genitourinary surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
"Department of Renal and Genitourinary surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.",
"Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan."
] |
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[] | 9.663105 | 4.390255 |
39538378
| 254 |
Research trends of cellular immunotherapy for primary liver cancer: A bibliometric analysis.
|
Cellular immunotherapy has shown considerable potential for the treatment of primary liver cancer (PLC), particularly hepatocellular carcinoma (HCC), although it is in the early stages of development. This study used bibliometric methods to delineate the evolution of research on cellular immunotherapy for PLC. Data were sourced from the Web of Science Core Collection (WoSCC) on April 22, 2024. Using the "Bibliometrix" R package, we examined primary bibliometric features, collaboration frequency between countries, and article output of the journals. Furthermore, we employed VOSviewer for coauthorship analysis and visualization and CiteSpace to assess keyword co-occurrence, as well as to spotlight keywords and references with the strongest citation bursts. Our analysis encompassed 492 publications focused on PLC and cellular immunotherapy, and we pinpointed China, Japan, and the USA as the foremost contributing nations and identified "
|
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] | 2024-11-14 | 48 |
39538378
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[
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|
[
"Wu",
"Jin",
"Liu",
"Mao",
"Wan",
"Du"
] |
[
"Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China."
] |
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[] | 10.972207 | 4.018803 |
39538038
| 255 |
CAR-engineered NK cells versus CAR T cells in treatment of glioblastoma; strength and flaws.
|
Glioblastoma (GBM) is a highly aggressive primary brain tumor that carries a grim prognosis. Because of the dearth of treatment options available for treatment of GBM, Chimeric Antigen Receptor (CAR)-engineered T cell and Natural Killer (NK) therapy could provide alternative strategies to address the challenges in GBM treatment. In these approaches, CAR T and NK cells are engineered for cancer-specific immunotherapy by recognizing surface antigens independently of major histocompatibility complex (MHC) molecules. However, the efficacy of CAR T cells is hindered by GBM's downregulation of its targeted antigens. CAR NK cells face similar challenges, but, in contrast, they offer advantages as off-the-shelf allogeneic products, devoid of graft-versus-host disease (GVHD) risk as well as anti-cancer activity beyond CAR specificity, potentially reducing the risk of relapse or resistance. Despite CAR T cell therapies being extensively studied in clinical settings, the use of CAR-modified NK cells in GBM treatment remains largely in the preclinical stage. This review aims to discuss recent advancements in NK cell and CAR T cell therapies for GBM, including methods for introducing CARs into both NK cells and T cells, addressing manufacturing challenges, and providing evidence supporting the efficacy of these approaches from preclinical and early-phase clinical studies. The comprehensive evaluation of CAR-engineered NK cells and CAR T cells seeks to identify the optimal therapeutic approach for GBM, contributing to the development of effective immunotherapies for this devastating disease.
|
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39538038
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10.1007/s11060-024-04876-z
10.1111/nan.12432
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10.1038/nrdp.2015.17
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10.1016/j.mehy.2020.109559
10.18632/oncotarget.17792
10.1586/14760584.5.6.793
10.1038/labinvest.3700233
10.1038/nrc.2016.97
10.1016/j.coi.2016.06.004
10.1016/j.smim.2014.02.004
10.1038/bmt.2009.304
10.1200/JCO.2009.24.4590
10.1158/2159-8290.CD-15-1020
10.1016/S0140-6736(14)61403-3
10.1016/j.jaci.2013.07.006
10.1016/j.smim.2017.08.002
10.1038/ni.3518
10.1016/S0074-7696(06)50006-3
10.1007/s00005-012-0203-0
10.1016/j.trsl.2017.07.003
10.3389/fnins.2021.662064
10.1016/j.jneuroim.2023.578146
10.1002/cti2.1049
10.1016/j.immuni.2016.04.020
10.1038/sigtrans.2017.23
10.1016/j.ymthe.2018.09.009
10.1111/imr.12125
10.1038/s41598-017-10940-8
10.1038/s41591-018-0036-4
10.1038/mt.2010.24
10.1200/JCO.2014.58.0225
10.1002/pros.23214
10.1038/nm.1882
10.1056/NEJMoa1610497
10.1038/mto.2016.11
10.1186/s12943-022-01711-9
10.1038/s41586-022-04489-4
10.1016/j.ymthe.2017.06.012
10.1038/s41573-019-0051-2
10.1186/s12896-020-00665-4
10.3389/fimmu.2024.1401683
10.1016/j.ymthe.2017.02.005
10.1016/j.omto.2023.08.009
10.1016/j.cell.2013.09.034
10.1097/01.COC.0000020922.66984.E7
10.1158/0008-5472.CAN-07-1493
10.1126/science.1254257
10.1016/j.ccr.2009.12.020
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10.1158/1078-0432.CCR-15-0428
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10.1182/blood-2015-01-621474
10.1158/1078-0432.Ccr-21-1392
10.1158/2326-6066.Cir-21-1075
10.1038/s41698-024-00522-z
10.1007/s11060-015-1849-3
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10.4049/jimmunol.133.1.273
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10.1038/s41591-018-0337-7
10.1038/s41591-018-0339-5
10.1038/s41591-019-0349-y
10.1016/j.omto.2018.08.002
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10.3389/fimmu.2022.904133
10.1093/neuonc/noad179.0897
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10.1126/science.1068440
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10.4049/jimmunol.1701155
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10.1016/j.jcyt.2016.05.018
10.3389/fimmu.2024.1368290
10.3389/fimmu.2015.00266
10.1016/j.heliyon.2024.e27196
10.1371/journal.pone.0142767
10.1093/neuonc/nov318
10.1016/j.medj.2024.09.010
10.1080/21645515.2015.1096458
10.1038/nrc.2015.5
10.1016/j.jcyt.2014.09.007
10.3171/2016.9.JNS16943
10.1002/cti2.1507
10.1186/s12943-023-01735-9
10.1038/s41388-023-02738-y
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10.1016/j.isci.2021.102619
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10.3390/cancers14174318
10.1186/s13045-021-01083-5
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[
"Sabahi",
"Fathi Jouzdani",
"Sadeghian",
"Dabbagh Ohadi",
"Sultan",
"Salehipour",
"Maniakhina",
"Rezaei",
"Adada",
"Mansouri",
"Borghei-Razavi"
] |
[
"Department of Neurological Surgery, Pauline Braathen Neurological Center, Cleveland Clinic Florida, Weston, FL, USA.",
"Neurosurgery Research Group (NRG), Hamadan University of Medical Sciences, Hamadan, Iran.\nBrain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.",
"Department of Pathology & Laboratory Medicine, Cleveland Clinic Florida, Weston, FL, USA.",
"Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran.",
"Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.",
"Neurosurgery Research Group (NRG), Hamadan University of Medical Sciences, Hamadan, Iran.\nBrain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.",
"Department of Neurosurgery, Geisinger and Geisinger Commonwealth School of Medicine, Wilkes-Barre, PA, USA.",
"Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.\nDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.",
"Department of Neurological Surgery, Pauline Braathen Neurological Center, Cleveland Clinic Florida, Weston, FL, USA.",
"Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA. amansouri@pennstatehealth.psu.edu.",
"Department of Neurological Surgery, Pauline Braathen Neurological Center, Cleveland Clinic Florida, Weston, FL, USA."
] |
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] |
[] | 10.130451 | 7.342193 |
39537919
| 256 |
Intravenous and intracranial GD2-CAR T cells for H3K27M
|
H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref.
|
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] | 2024-11-14 | 36 |
39537919
|
[
"high levels",
"H3K27M-mutant diffuse midline gliomas",
"DMGs",
"ref",
"the disialoganglioside",
"GD2 (ref"
] |
[] | 0 |
10.1038/s41586-024-08171-9
|
[
"Monje",
"Mahdi",
"Majzner",
"Yeom",
"Schultz",
"Richards",
"Barsan",
"Song",
"Kamens",
"Baggott",
"Kunicki",
"Rietberg",
"Lim",
"Reschke",
"Mavroukakis",
"Egeler",
"Moon",
"Patel",
"Chinnasamy",
"Erickson",
"Jacobs",
"Duh",
"Tunuguntla",
"Klysz",
"Fowler",
"Green",
"Beebe",
"Carr",
"Fujimoto",
"Brown",
"Petersen",
"McIntyre",
"Siddiqui",
"Lepori-Bui",
"Villar",
"Pham",
"Bove",
"Musa",
"Reynolds",
"Kuo",
"Prabhu",
"Rasmussen",
"Cornell",
"Partap",
"Fisher",
"Campen",
"Grant",
"Prolo",
"Ye",
"Sahaf",
"Davis",
"Feldman",
"Ramakrishna",
"Mackall"
] |
[
"Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.\nDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.\nDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.\nDepartment of Pathology, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.\nHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.",
"Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.\nDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.\nDivision of Neuroradiology, Department of Radiology, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Department of Neurosurgery, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Cellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.",
"Cellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.",
"Cellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.",
"Cellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.",
"Cellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.",
"Cellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.",
"Cellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Department of Pediatrics, Division of Pediatric Critical Care Medicine, Stanford University, Stanford, CA, US.",
"Department of Pediatrics, Division of Pediatric Critical Care Medicine, Stanford University, Stanford, CA, US.",
"Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.",
"Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.",
"Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.",
"Department of Neurosurgery, Stanford University, Stanford, CA, USA.",
"Department of Neurosurgery, Stanford University, Stanford, CA, USA.",
"Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA. ramakrs@stanford.edu.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. ramakrs@stanford.edu.",
"Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA. cmackall@stanford.edu.\nStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. cmackall@stanford.edu.\nParker Institute for Cancer Immunotherapy, San Francisco, CA, USA. cmackall@stanford.edu.\nDivision of Stem Cell Transplantation and Cell Therapy, Department of Medicine, Stanford University, Stanford, CA, USA. cmackall@stanford.edu."
] |
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[] | 9.859793 | 7.002551 |
39537215
| 257 |
Better, Faster, Stronger: Accelerating mRNA-Based Immunotherapies With Nanocarriers.
|
Messenger ribonucleic acid (mRNA) therapeutics are attracting attention as promising tools in cancer immunotherapy due to their ability to leverage the in vivo expression of all known protein sequences. Even small amounts of mRNA can have a powerful effect on cancer vaccines by promoting the synthesis of tumor-specific antigens (TSA) or tumor-associated antigens (TAA) by antigen-presenting cells (APC). These antigens are then presented to T cells, eliciting strong antitumor immune stimulation. The potential of mRNA can be further enhanced by expressing immunomodulatory agents, such as cytokines, antibodies, and chimeric antigen receptors (CAR), enhancing tumor immunity. Recent research also explores mRNA-encoded tumor death inducers or tumor microenvironment (TME) modulators. Despite its promise, the clinical translation of mRNA-based anticancer strategies faces challenges, including inefficient targeted delivery in vivo, failure of endosomal escape, and inadequate intracellular mRNA release, resulting in poor transfection efficiencies. Inspired by the approval of lipid nanoparticle-loaded mRNA vaccines against coronavirus disease 2019 (COVID-19) and the encouraging outcomes of mRNA-based cancer therapies in trials, innovative nonviral nanotechnology delivery systems have been engineered. These aim to advance mRNA-based cancer immunotherapies from research to clinical application. This review summarizes recent preclinical and clinical progress in lipid and polymeric nanomedicines for delivering mRNA-encoded antitumor therapeutics, including cytokines and antibody-based immunotherapies, cancer vaccines, and CAR therapies. It also addresses advanced delivery systems for direct oncolysis or TME reprogramming and highlights key challenges in translating these therapies to clinical use, exploring future perspectives, including the role of artificial intelligence and machine learning in their development.
|
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39537215
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[
"cancer vaccines",
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"T cells",
"artificial intelligence",
"poor transfection efficiencies",
"antibody-based immunotherapies",
"endosomal escape",
"direct oncolysis",
"immunomodulatory agents",
"tumor-specific antigens"
] |
[
"cancer immunotherapy",
"mRNA‐based delivery systems",
"messenger RNA (mRNA) therapeutics",
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] | 0 |
10.1002/wnan.2017
10.1002/advs.202404159
10.1038/mt.2010.85
10.1038/s41571-023-00832-4
10.1002/anie.202310395
10.1056/NEJMoa2028436
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10.1084/jem.20230903
10.1002/eji.202250039
10.1182/bloodadvances.2023012336
10.1038/s41587-022-01294-2
10.1007/s12032-023-02184-6
10.1016/j.ccell.2024.02.013
10.1186/s12943-021-01348-0
10.1002/smll.202304378
10.1021/acs.nanolett.1c02503
10.1021/acs.nanolett.9b04246
10.1084/jem.184.2.465
10.1039/D2SC00670G
10.1016/j.bbmt.2019.12.478
10.1038/s41571-023-00754-1
10.1038/s41467-024-50235-x
10.1016/j.chembiol.2022.10.005
10.1073/pnas.2207841119
10.1038/s41565-020-0669-6
10.1016/j.omtn.2023.07.026
10.3389/fimmu.2023.1294929
10.1200/EDBK_397912
10.1016/j.cub.2015.05.032
10.1038/s41565-019-0512-0
10.1002/adfm.202106727
10.1016/j.omtm.2022.11.009
10.2147/IJN.S452896
10.1038/s12276-018-0191-1
10.3390/vaccines9020108
10.1038/nrclinonc.2018.27
10.2217/nnm.13.118
10.1016/j.omtn.2023.07.020
10.1038/gt.2011.17
10.4049/immunohorizons.2300099
10.1038/s41467-023-42365-5
10.1002/adma.201606944
10.1038/s41565-020-0732-3
10.1038/s41586-022-05531-1
10.3390/cancers15102860
10.3390/ijms241713364
10.1016/j.biopha.2024.116603
10.3389/fchem.2020.589959
10.1002/wnan.1582
10.1007/s00262-019-02460-3
10.1002/smll.201805097
10.1002/adhm.202301515
10.1186/s40580-023-00385-3
10.1038/s41467-021-27493-0
10.1038/s41568-019-0116-x
10.1007/s00262-005-0064-z
10.1126/scitranslmed.aat9143
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10.1038/s41578-021-00379-9
10.1126/scitranslmed.abc7804
10.1038/s41578-021-00358-0
10.1016/j.jconrel.2020.06.029
10.1002/advs.202205532
10.2147/IJN.S447350
10.1038/s41591-022-02061-1
10.1038/s12276-024-01220-3
10.1016/j.jcyt.2021.08.005
10.1016/j.ijpharm.2007.11.005
10.1038/s41551-018-0284-0
10.1016/j.drudis.2019.12.003
10.1016/j.ebiom.2020.102931
10.1016/j.jconrel.2024.03.016
10.2217/nnm.11.19
10.1056/NEJMoa1001294
10.1038/nri3727
10.1080/17460441.2020.1811673
10.1016/j.biomaterials.2021.121339
10.1016/j.jconrel.2022.03.029
10.1016/j.omtm.2023.101139
10.1016/j.omto.2020.07.005
10.1038/s41587-020-0462-y
10.1002/anie.200902672
10.1186/2051-1426-2-S3-P85
10.1016/j.addr.2023.114993
10.2147/IJN.S29183
10.1126/scitranslmed.aaw1565
10.1016/j.ymthe.2019.02.012
10.1038/nature18300
10.1186/s40425-015-0068-y
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10.1038/s41573-021-00387-y
10.1016/j.jconrel.2018.03.035
10.1021/acsnano.3c13039
10.1016/j.jconrel.2020.08.009
10.1038/s12276-023-01086-x
10.1021/acs.molpharmaceut.0c00451
10.1002/wnan.1530
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10.3389/fimmu.2023.1303935
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10.1126/scitranslmed.aba9772
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10.1016/j.jconrel.2022.03.021
10.1016/j.ymthe.2017.10.020
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10.1016/j.jconrel.2006.04.014
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10.1016/j.jconrel.2019.06.017
10.1002/advs.202300299
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10.1038/s41571-021-00507-y
10.1002/adtp.202000099
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10.1016/j.lfs.2020.118110
10.1002/adfm.202312038
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10.1136/jitc-2022-006434
10.1016/j.biomaterials.2023.122185
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10.1016/j.jcyt.2024.02.024
10.1021/acsanm.0c01834
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10.1002/adfm.202401749
10.1016/j.addr.2021.03.001
10.1038/s41467-019-13368-y
10.3389/fimmu.2019.02630
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10.1016/j.addr.2023.115026
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10.1146/annurev-cancerbio-061521-082320
10.1021/acsnano.5b02796
10.1038/s41573-018-0006-z
10.1038/s41587-022-01491-z
10.1038/s41586-023-06063-y
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10.1038/s41586-020-2537-9
10.3390/antib10040037
10.1038/s41571-024-00902-1
10.1080/2162402X.2016.1256527
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10.3390/ph15081017
10.1021/acsnano.3c06733
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10.1016/j.tips.2024.03.004
10.1038/nm.4356
10.1056/NEJMoa1106152
10.1002/ijc.34635
10.1016/j.addr.2015.09.012
10.1016/j.pharmthera.2019.04.006
10.1038/s41590-022-01160-y
10.1073/pnas.2304966120
10.15252/emmm.201707678
10.3390/vaccines9091033
10.1186/s12967-019-1804-8
10.1158/0008-5472.CAN-11-2957
10.1158/2326-6066.CIR-15-0163
10.1038/s41467-018-06936-1
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10.3390/pharmaceutics12020102
10.1056/NEJMoa2027906
10.1038/s41586-020-2079-1
10.1038/s41420-024-01815-9
10.1002/adma.202007603
10.1016/j.ymthe.2017.11.009
10.1126/science.aba1786
10.1016/S0140-6736(23)02268-7
10.3389/fimmu.2022.1035276
10.1021/jacs.0c09343
10.1182/bloodadvances.2020002355
10.1016/j.tibtech.2023.08.005
10.7150/jca.63991
10.1038/s41467-022-28279-8
10.1038/d41573-021-00147-y
10.1016/j.omtn.2022.09.010
10.1002/wnan.1339
10.1016/j.bioactmat.2020.07.003
10.1038/s41587-022-01567-w
10.1016/j.jconrel.2023.07.021
10.1021/acsbiomaterials.1c01532
10.1038/s41551-024-01208-4
10.1186/s40824-023-00425-3
10.1007/82_2020_217
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10.1021/acscentsci.3c01511
10.1021/acs.chemrev.1c00244
10.1038/s41586-020-2071-9
10.1186/s12967-023-04553-1
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|
[
"Carvalho",
"Fidalgo",
"Acúrcio",
"Matos",
"Satchi-Fainaro",
"Florindo"
] |
[
"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.",
"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.",
"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.",
"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.",
"Department of Physiology and Pharmacology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.\nSagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.",
"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal."
] |
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[] | 10.023035 | 3.461794 |
39536093
| 258 |
TET2 regulates early and late transitions in exhausted CD8
|
CD8
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] | 2024-11-14 | 100 |
39536093
|
[
"CD8"
] |
[] | 0 |
10.1126/sciadv.adp9371
|
[
"Dimitri",
"Baxter",
"Chen",
"Hopkins",
"Rouin",
"Huang",
"Kong",
"Holliday",
"Wiebking",
"Bartoszek",
"Drury",
"Dalton",
"Koucky",
"Chen",
"Giles",
"Dils",
"Jung",
"O'Connor",
"Collins",
"Everett",
"Amses",
"Sherrill-Mix",
"Chandra",
"Goldman",
"Vahedi",
"Jadlowsky",
"Young",
"Melenhorst",
"Maude",
"Levine",
"Frey",
"Berger",
"Grupp",
"Porter",
"Herbst",
"Porteus",
"Carty",
"Bushman",
"Weber",
"Wherry",
"Jordan",
"Fraietta"
] |
[
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment for Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment for Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics,, Stanford University, Palo Alto, CA 94304, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment for Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment for Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nEpigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI 48824, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nEpigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nEpigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nEpigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA.",
"Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nEpigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.",
"Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDivision of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics,, Stanford University, Palo Alto, CA 94304, USA.",
"Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment for Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."
] |
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[] | 33.513828 | 7.035285 |
39535595
| 259 |
Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia.
|
Immunotherapy, such as chimeric antigen receptor T (CAR-T) cells targeting CD33 or CD123, has been well developed over the past decade for the treatment of acute myeloid leukemia (AML). However, the inability to sustain tumor-free survival and the possibility of relapse due to antigen loss have raised concerns. A dual targeting of CD33 and CD123 is needed for better outcomes.
Based on our previously constructed CD33 and CD123 monovalent CAR-T, Loop33 × 123 and Loop123 × 33 CAR-T were constructed with molecular cloning techniques. All CAR-T cells were generated by lentivirus transduction of T cells from healthy donors. Phenotype detection was evaluated on day 7 concerning activation, exhaustion, and subtype proportions. Coculture killing assays were conducted using various AML cell lines and primary AML cells. Degranulation and cytokine secretion levels were detected by flow cytometry. Cell-derived xenograft models were established using wild-type Molm 13 cell lines, or a mixture of Molm 13-KO33 and Molm 13-KO123 cells as an ideal model of immune escape. By monitoring body weight and survival of tumor-bearing mice, Loop33 × 123 and Loop123 × 33 CAR-T cells were further assessed for their efficacy in vivo.
In vitro study, our results demonstrated that Loop33 × 123 CAR-T cells could efficiently eliminate AML cell lines and primary AML cells with elevated degranulation and cytokine secretion levels. Compared with our previously constructed monovalent CD33 or CD123 CAR-T cells, Loop33 × 123 CAR-T cells showed superior advantages in an immune escape model. In vivo studies further confirmed that Loop33 × 123 CAR-T cells could effectively prolong the survival of mice without significant toxicity. However, Loop123 × 33 CAR-T cells failed to show the same effects. Furthermore, Loop33 × 123 CAR-T cells efficiently circumvented potential immune escape, a challenge where monovalent CAR-T cells failed.
Loop33 × 123 CAR-T targeting CD33 and CD123 could efficiently eliminate AML cells and prolong survival of tumor-bearing mice, while addressing the issue of immune escape.
|
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39535595
|
[
"T cells",
"AML cells",
"AML cell lines",
"primary AML cells",
"various AML cell lines",
"CD123 CAR-T cells",
"monovalent CAR-T cells",
"potential immune escape",
"prolong survival",
"immune escape",
"CD123 CAR-T",
"CD123",
"cytokine secretion levels",
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"CD33",
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"33 CAR-T cells",
"chimeric antigen receptor T (CAR-T) cells",
"Loop33",
"mice",
"wild-type Molm 13 cell lines",
"antigen loss",
"All CAR-T cells",
"elevated degranulation",
"acute myeloid leukemia",
"Coculture killing assays",
"Loop33 × 123 CAR-T cells",
"tumor-free survival"
] |
[
"AML",
"CD123",
"CD33",
"Chimeric antigen receptor"
] | 0 |
10.1007/s00262-024-03847-7
|
[
"Ma",
"Yan",
"Gu",
"Xu",
"Qiu",
"Xing",
"Tang",
"Tian",
"Rao",
"Wang",
"Wang"
] |
[
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China. wangjxm@ihcams.ac.cn.\nTianjin Institutes of Health Science, Tianjin, 301617, China. wangjxm@ihcams.ac.cn.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China. wangjx@ihcams.ac.cn.\nTianjin Institutes of Health Science, Tianjin, 301617, China. wangjx@ihcams.ac.cn."
] |
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[] | 6.961609 | 7.156167 |
39533710
| 260 |
Optimizing CAR-T treatment: A T
|
Chimeric antigen receptor (CAR)-T cell products, classified as Advanced Therapy Medicinal Products (ATMPs), have shown promising outcomes in cancer immunotherapy. The quality of raw and starting materials used in manufacturing is critical to ensure the efficacy and safety of CAR-T cell products and depends primarily on the selection of the right materials and the right suppliers. It is essential to consider a long-term strategy when selecting raw and starting materials to prevent delays in the supply of innovative, high-quality, and safe therapies to patients. A thorough assessment will allow developers not only to select suppliers who comply with regulatory requirements but also to ensure a sustainable supply of materials throughout the development and the commercial phases. A careful selection of materials and suppliers can avoid the need of comparability studies due to changes in the supply of materials, impacting costs and causing significant delays in development and treatment readiness for patients. This work, coordinated by the T
|
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] | 2024-11-13 | 1 |
39533710
|
[
"materials",
"Advanced Therapy Medicinal Products",
"significant delays",
"suppliers",
"promising outcomes",
"Chimeric antigen receptor",
"raw and starting materials",
"delays",
"comparability studies",
"regulatory requirements",
"impacting costs",
"CAR-T cell products",
"cancer immunotherapy",
"the right materials",
"(CAR)-T cell products",
"ATMPs",
"CAR)-T",
"developers",
"patients",
"safety",
"manufacturing",
"changes",
"development and treatment readiness",
"the right suppliers",
"a sustainable supply",
"the supply",
"A careful selection",
"a long-term strategy",
"innovative, high-quality, and safe therapies",
"A thorough assessment"
] |
[
"CAR-T cells",
"GMP",
"clinical trials",
"comparability",
"quality",
"raw material",
"stability",
"starting material",
"supplier selection",
"viral safety"
] | 0 |
10.1016/j.ymthe.2024.11.017
|
[
"Navarro",
"Moukheiber",
"Inogés Sancho",
"Ruiz Guillén",
"López-Díaz de Cerio",
"Sanges",
"Tanaka",
"Arnould",
"Briones",
"Dolstra",
"Hudecek",
"Choudhary",
"Schapitz",
"Juan",
"Worel",
"Ammar",
"Luu",
"Müller",
"Schroeder",
"Negre",
"Franz"
] |
[
"Hospital Clínic de Barcelona, Secció d'Immunoterapia - Servei d'Immunologia, Barcelona, Spain. Electronic address: senavarro@clinic.cat.",
"Institut de Recherches Internationales Servier, Gif-sur-Yvette, France. Electronic address: carole.moukheiber@servier.com.",
"Clínica Universidad de Navarra, Hematología- Área de Terapia Celular, Pamplona, Spain. Electronic address: sinoges@unav.es.",
"Clínica Universidad de Navarra, Hematología- Área de Terapia Celular, Pamplona, Spain.",
"Clínica Universidad de Navarra, Hematología- Área de Terapia Celular, Pamplona, Spain.",
"Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.",
"Astellas Pharma Inc, Tokyo, Japan.",
"Institut de Recherches Internationales Servier, Gif-sur-Yvette, France.",
"Hospital de Sant Pau, Hematology Department, Barcelona, Spain.",
"Radboud University Medical Center, Department of Laboratory Medicine, Nijmegen, the Netherlands.",
"Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany; Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.",
"Takeda Development Centers Americas, Inc, Lexington, MA, USA.",
"Bayer Vital GmbH, Leverkusen, Germany.",
"Hospital Clínic de Barcelona, Secció d'Immunoterapia - Servei d'Immunologia, Barcelona, Spain.",
"Medical University of Vienna, Department of Transfusion Medicine and Cell Therapy, Vienna, Austria.",
"Astellas Pharma B.V., Leiden, the Netherlands.",
"Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.",
"Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.",
"Miltenyi Biotec B.V. & Co KG, Bergisch Gladbach, Germany.",
"Institut de Recherches Internationales Servier, Gif-sur-Yvette, France.",
"Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany. Electronic address: paul.franz@izi.fraunhofer.de."
] |
[
"39533710"
] |
[] | 8.601646 | 3.325509 |
39533105
| 261 |
Beyond the blood: expanding CAR T cell therapy to solid tumors.
|
Chimeric antigen receptor (CAR) T cell therapy stands as a transformative advancement in immunotherapy, triumphing against hematological malignancies and, increasingly, autoimmune disorders. After a decade of relatively modest results for solid tumors, recent clinical trials and patient reports have also started to yield promising outcomes in glioblastoma and other challenging solid tumor entities. This Perspective seeks to explore the reasons behind these latest achievements and discusses how they can be sustained and expanded through different strategies involving CAR engineering and synthetic biology. Furthermore, we critically analyze how these breakthroughs can be leveraged to maintain momentum and broaden the therapeutic impact of CAR T cells across a variety of solid tumor landscapes.
|
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39533105
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[
"Uslu",
"June"
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[
"Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.\nParker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.\nParker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu."
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[] | 9.147708 | 4.181095 |
39532433
| 262 |
ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis.
|
The failure of conventional therapies and the propensity for recurrence and metastasis make triple-negative breast cancer (TNBC) a formidable challenge with grim prognoses and diminished survival rates. Immunotherapy, including immune checkpoint blockade and chimeric antigen receptor (CAR)-T cell therapy, presents innovative and potentially more effective strategies for addressing TNBC. Within this context, the inducible costimulator (ICOS), a member of the CTLA4/CD28 family, plays a crucial role in regulating immune responses and T-cell differentiation by binding to its ligand ICOSL. However, the impact of the ICOS/ICOSL axis on cancer varies.
In this study, immunohistochemistry was conducted to examine the expression level of ICOSL in TNBC tumor tissues. We developed ICOS-enhanced B7H3-CAR-T cells (ICOS-B7H3-CAR) using the third-generation CAR-T cell technology, which featured magnified ICOS expression and targeted the B7H3 antigen. Xenograft and metastasis models of TNBC were conducted to examine the cytotoxicity and durability of CAR-T cells in tumors. Overexpression and CRISPR/Cas9-mediated knockout (KO) techniques were employed to regulate the expression of ICOSL on TNBC cell lines.
Notably, we observed elevated ICOSL expression in TNBC tumor tissues, which correlated with poor survival prognosis in patients with TNBC. Compared with conventional B7H3-CAR-T cells, ICOS-B7H3-CAR-T cells significantly inhibited the tumor growth of TNBC cells both in vitro and in vivo, accompanied by increased secretion of cytokines such as interferon gamma and tumor necrosis factor alpha. Furthermore, the in vivo experiments illustrated that ICOS-B7H3-CAR-T cells exhibited prolonged antitumor activity and could effectively eradicate metastases in a TNBC metastasis model, consequently extending survival. Importantly, manipulating the expression of ICOSL on TNBC cells through overexpression or KO significantly influenced the function of ICOS-B7H3-CAR-T cells. This suggests that the level of ICOSL expression on TNBC cells is critical for enhancing the potent antitumor effects of ICOS-B7H3-CAR-T cells.
Overall, our study highlights the potential clinical application of ICOS as a promising strategy for combating TNBC recurrence and metastasis.
|
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] | 2024-11-13 | 55 |
39532433
|
[
"TNBC cells",
"TNBC cell lines",
"ICOS expression",
"TNBC tumor tissues",
"TNBC recurrence",
"CAR)-T cell therapy",
"TNBC",
"ICOSL expression",
"ICOS",
"B7H3",
"CAR-T cells",
"ICOSL",
"metastasis models",
"T-cell differentiation",
"tumor necrosis factor alpha",
"poor survival prognosis",
"conventional B7H3-CAR-T cells",
"a TNBC metastasis model",
"metastases",
"metastasis",
"ICOS-enhanced B7H3-CAR-T cells",
"immune checkpoint blockade",
"tumors",
"ICOS-B7H3-CAR-T cells",
"chimeric antigen receptor",
"conventional therapies",
"diminished survival rates",
"immune responses",
"grim prognoses",
"ICOS-B7H3-CAR"
] |
[
"Immunotherapy"
] | 0 |
10.1136/jitc-2024-010028
10.1186/s13046-022-02476-1
10.1158/2159-8290.CD-18-1177
10.1038/s41523-022-00500-3
10.1016/j.trecan.2024.02.008
10.1186/s13045-018-0635-z
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10.1016/j.canlet.2020.07.044
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10.1182/blood-2013-10-535245
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10.1016/j.biomaterials.2012.10.018
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10.1016/j.semcancer.2017.10.001
10.1136/esmoopen-2019-000544
10.4049/jimmunol.181.3.1969
10.1038/ni.3050
|
[
"Cao",
"Peng",
"Chen",
"Xia",
"Zeng",
"Guo",
"Yu",
"Ye",
"Zhang",
"Chen"
] |
[
"Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.",
"Department of Breast Surgery, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.\nGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, Guangdong, China.",
"Department of Gynecology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.",
"Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.\nGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, Guangdong, China.",
"Department of Breast Surgery, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.",
"Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.",
"Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China chenxinxin@gzhmu.edu.cn zhangh92@mail.sysu.edu.cn yehaiyan@gdph.org.cn yufei@gdph.org.cn.",
"Department of Gynecology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China chenxinxin@gzhmu.edu.cn zhangh92@mail.sysu.edu.cn yehaiyan@gdph.org.cn yufei@gdph.org.cn.",
"Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China chenxinxin@gzhmu.edu.cn zhangh92@mail.sysu.edu.cn yehaiyan@gdph.org.cn yufei@gdph.org.cn.",
"Department of Breast Surgery, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China chenxinxin@gzhmu.edu.cn zhangh92@mail.sysu.edu.cn yehaiyan@gdph.org.cn yufei@gdph.org.cn."
] |
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[] | 9.91848 | 5.818245 |
39530971
| 263 |
Successful generation of fully human, second generation, anti-CD19 CAR T cells for clinical use in patients with diverse autoimmune disorders.
|
B-cell targeting chimeric antigen receptor (CAR) T-cell therapies, which lead to profound B-cell depletion, have been well-established in hematology-oncology. This deep B-cell depletion mechanism has prompted the exploration of their use in B-cell driven autoimmune diseases. We herein report on the manufacturing of KYV-101, a fully human anti-CD19 CAR T-cell therapy, derived from patients who were treated across a spectrum of autoimmune diseases.
KYV-101 was manufactured from peripheral blood-derived mononuclear cells of 20 patients across seven autoimmune disease types (neurological autoimmune diseases, n = 13; rheumatological autoimmune diseases, n = 7). Patients ranged from 18 to 75 years of age. Duration of disease ranged from <1 to 23 years since diagnosis. Patients were heavily pretreated, and most were refractory to prior immunosuppressive treatments. Apheresis was collected across nine sites, cryopreserved, and shipped to the manufacturing facility. Healthy donor apheresis samples were collected for manufacturing comparison. Manufacturing was performed using the CliniMACS Prodigy system. Cells were enriched for CD4
KYV-101 was successfully manufactured for 100% of patients. Transduced cell populations were highly viable, with expansion ranging from 11 to 66 fold at Day 8, and were comparable across disease types. Healthy donor-derived controls displayed similar expansion ranges. High CAR expression and transduction rates were observed, ranging between 37 and 77% with low variation in transgene copy number (two to four per cell). Cell viability of the final KYV-101 drug product ranged from 87 to 97%. KYV-101 displayed robust CD19-dependent and effector dose-related release of the pro-inflammatory cytokine IFN-γ.
KYV-101 manufacturing yielded a CAR T-cell product with high viability and consistent composition and functionality, regardless of disease indication, pre-treatment, and heterogeneity of the incoming material. Cryopreservation of the apheresis and final drug product enabled widespread distribution. These results support the robustness of the manufacturing process for the fully human KYV-101 anti-CD19 CAR T-cell therapy drug product for patients across diverse autoimmune disease types.
|
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] | 2024-11-13 | 1 |
39530971
|
[
"Cell viability",
"Cells",
"cell",
"Transduced cell populations",
"KYV-101 manufacturing",
"autoimmune diseases",
"rheumatological autoimmune diseases",
"diverse autoimmune disease types",
"neurological autoimmune diseases",
"final drug product",
"disease indication",
"disease types",
"B-cell driven autoimmune diseases",
"disease",
"KYV-101",
"Patients",
"patients",
"B-cell targeting chimeric antigen receptor",
"profound B-cell depletion",
"Healthy donor apheresis samples",
"Manufacturing",
"peripheral blood-derived mononuclear cells",
"the fully human KYV-101 anti-CD19 CAR T-cell therapy drug product",
"High CAR expression",
"the final KYV-101 drug product",
"high viability",
"similar expansion ranges",
"a fully human anti-CD19 CAR T-cell therapy",
"manufacturing comparison",
"prior immunosuppressive treatments"
] |
[
"anti-CD19 chimeric antigen receptor",
"manufacturing",
"neurological autoimmune disease",
"rheumatological autoimmune disease"
] | 0 |
10.1016/j.jcyt.2024.09.008
|
[
"Mougiakakos",
"Sengupta",
"Gold",
"Schroers",
"Haghikia",
"Lorente",
"Pendleton",
"Register",
"Heesen",
"Kröger",
"Schett",
"Mackensen",
"Podoll",
"Gutman",
"Furie",
"Bayer",
"Distler",
"Dietrich",
"Krönke",
"Bullinger",
"Walker"
] |
[
"Department of Hematology, Oncology, and Cell Therapy, Otto-von-Guericke University, Magdeburg, Germany.",
"Kyverna Therapeutics, Inc, Emeryville, California, USA. Electronic address: rsengupta@kyvernatx.com.",
"Department of Neurology, Ruhr University Bochum, Bochum, Germany.",
"Department of Hematology and Oncology, Ruhr University Bochum, Bochum, Germany.",
"Department of Neurology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.",
"Kyverna Therapeutics, Inc, Emeryville, California, USA.",
"Kyverna Therapeutics, Inc, Emeryville, California, USA.",
"Kyverna Therapeutics, Inc, Emeryville, California, USA.",
"Institute of Neuroimmunology and Multiple Sclerosis and Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.",
"Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.",
"Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nürnberg, Erlangen, Germany.",
"Department of Internal Medicine 5 - Hematology and Oncology, Friedrich-Alexander-University (FAU) Erlangen-Nürnberg, Erlangen, Germany.",
"Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Hematology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Rheumatology, Northwell Health, Great Neck, New York, USA.",
"Department of Hematology/Oncology, Northwell Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, New York, USA.",
"Department of Rheumatology and Hiller Research Center, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.",
"Department of Hematology, Oncology and Immunology, University Hospital of Düsseldorf, Düsseldorf, Germany.",
"Department of Rheumatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.",
"Department of Hematology, Oncology and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.",
"Kyverna Therapeutics, Inc, Emeryville, California, USA."
] |
[
"39530971"
] |
[] | 8.526245 | 3.091718 |
39528665
| 264 |
TRBC1-CAR T cell therapy in peripheral T cell lymphoma: a phase 1/2 trial.
|
Relapsed/refractory peripheral T cell lymphomas (PTCLs) are aggressive tumors with a poor prognosis. Unlike B cell lymphomas, treatment of PTCL has not benefited from advances in immunotherapy. This is largely due to a lack of suitable target antigens that discriminate malignant from normal T cells, thus avoiding severe immunosuppression consequent to depletion of the entire T cell compartment. We recently described a targeting strategy based on the mutually exclusive expression of T cell antigen receptor beta-chain constant domain (TRBC) 1 and 2. Selective targeting of the T cell antigen receptor beta-chain expressed by the (clonal) malignancy spares normal T cells expressing the other chain. The LibraT1 study is an ongoing, multicenter, international, single-arm phase 1/2 study of TRBC1-directed autologous chimeric antigen receptor (CAR) T cells (AUTO4) in relapsed/refractory TRBC1-positive PTCL. Primary objectives were assessment of safety and tolerability of AUTO4 infusion. Key secondary endpoints included efficacy, CAR T cell expansion and persistence. Here we describe the findings from dose escalation in LibraT1 in the first ten patients, in a non-prespecified interim analysis. AUTO4 resulted in low frequency of severe immunotoxicity, with one of ten patients developing grade 3 cytokine release syndrome. Complete metabolic response was observed in four of ten evaluable patients, with remissions being durable beyond 1 year in two patients. While an absence of circulating CAR T cells was observed, CAR T cells were readily detected in lymph node biopsy samples from sites of original disease suggesting homing to tumor sites. These results support the continuing exploration of TRBC1 targeting in PTCL. ClinicalTrials.gov registration: NCT03590574 .
|
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] | 2024-11-13 | 22 |
39528665
|
[
"T cells",
"normal T cells",
"CAR T cells",
"CAR T cell expansion",
"circulating CAR T cells",
"B cell lymphomas",
"T cell antigen receptor beta-chain constant domain",
"Relapsed/refractory peripheral T cell lymphomas",
"suitable target antigens",
"the entire T cell compartment",
"the T cell antigen receptor beta-chain",
"severe immunosuppression consequent",
"tumor sites",
"lymph node biopsy samples",
"severe immunotoxicity",
"TRBC1-directed autologous chimeric antigen receptor",
"AUTO4 infusion",
"TRBC1",
"aggressive tumors",
"AUTO4",
"PTCL",
"original disease",
"Key secondary endpoints",
"Complete metabolic response",
"low frequency",
"CAR",
"LibraT1",
"Primary objectives",
"sites",
"a non-prespecified interim analysis"
] |
[] | 0 |
10.1038/s41591-024-03326-7
|
[
"Cwynarski",
"Iacoboni",
"Tholouli",
"Menne",
"Irvine",
"Balasubramaniam",
"Wood",
"Shang",
"Xue",
"Zhang",
"Basilico",
"Neves",
"Raymond",
"Scott",
"El-Kholy",
"Jha",
"Dainton-Smith",
"Hussain",
"Day",
"Ferrari",
"Thomas",
"Lilova",
"Brugger",
"Marafioti",
"Lao-Sirieix",
"Maciocia",
"Pule"
] |
[
"Department of Haematology, University College London, London, UK.\nUniversity College London Hospital, London, UK.",
"Department of Haematology, Vall d'Hebron University Hospital, Barcelona, Spain.",
"Department of Haematology, Manchester Royal Infirmary, Manchester, UK.",
"The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.",
"Queen Elizabeth University Hospital, Glasgow, UK.",
"University College London Hospital, London, UK.",
"University College London Hospital, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"Autolus Therapeutics, London, UK.",
"University College London Hospital, London, UK.",
"Autolus Therapeutics, London, UK.",
"Department of Haematology, University College London, London, UK.\nUniversity College London Hospital, London, UK.",
"Department of Haematology, University College London, London, UK. m.pule@ucl.ac.uk.\nAutolus Therapeutics, London, UK. m.pule@ucl.ac.uk."
] |
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[] | 6.62992 | 5.752203 |
39528513
| 265 |
Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies.
|
To address immune escape, multi-specific CAR-T-cell strategies use natural ligands that specifically bind multiple receptors on malignant cells. In this context, we propose a split CAR design comprising a universal receptor expressed on T cells and ligand-based switch molecules, which preserves the natural trimeric structure of ligands like APRIL and BAFF. Following optimization of the hinges and switch labeling sites, the split-design CAR-T cells ensure the native conformation of ligands, facilitating the optimal formation of immune synapses between target cancer cells and CAR-T cells. Our CAR-T-cell strategy demonstrates antitumor activities against various B-cell malignancy models in female mice, potentially preventing immune escape following conventional CAR-T-cell therapies in the case of antigen loss or switching. This ligand-based split CAR design introduces an idea for optimizing CAR recognition, enhancing efficacy and potentially improving safety in clinical translation, and may be broadly applicable to cellular therapies based on natural receptors or ligands.
|
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] | 2024-11-13 | 61 |
39528513
|
[
"T cells",
"target cancer cells",
"malignant cells",
"natural ligands",
"natural receptors",
"immune escape",
"ligands",
"CAR",
"CAR recognition",
"immune synapses",
"CAR-T cells",
"multiple receptors",
"cellular therapies",
"various B-cell malignancy models",
"conventional CAR-T-cell therapies",
"immune escape, multi-specific CAR-T-cell strategies",
"This ligand-based split CAR design",
"ligand-based switch molecules",
"clinical translation",
"labeling sites",
"female mice",
"antitumor activities",
"switch molecules",
"antigen loss",
"the split-design CAR-T cells",
"a split CAR design",
"Our CAR-T-cell strategy",
"the natural trimeric structure",
"safety",
"efficacy"
] |
[] | 0 |
10.1038/s41467-024-54150-z
|
[
"Li",
"Shi",
"Zhao",
"Guo",
"Li",
"Liu",
"Guo",
"Cao"
] |
[
"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.",
"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.",
"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.",
"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.",
"Fundamenta Therapeutics Co., Ltd, Suzhou, Jiangsu, China.",
"Department of Hematology, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, Guangdong, China.",
"Department of Hematology, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, Guangdong, China.",
"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China. joshuacao@pku.edu.cn.\nInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China. joshuacao@pku.edu.cn."
] |
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[] | 8.645355 | 4.819412 |
39524212
| 266 |
CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer.
|
The E6 and E7 oncoproteins of human papillomavirus (HPV) are considered promising targets for HPV-related cancers. In this study, we evaluated novel T cell receptor mimic (TCRm) nanobodies targeting the E6
|
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] | 2024-11-13 | 44 |
39524212
|
[
"human papillomavirus",
"promising targets",
"E7 oncoproteins",
"HPV",
"E6",
"novel T cell receptor mimic (TCRm) nanobodies",
"E7",
"HPV-related cancers",
"The E6",
"the E6",
"this study",
"we"
] |
[
"CAR-T",
"E6-MHC",
"HPV16+",
"TCR mimic",
"cervical cancer",
"nanobody"
] | 0 |
10.1016/j.omton.2024.200892
10.1158/1535-7163.MCT-21-0115
10.3389/fimmu.2017.01001
10.1016/j.ccell.2020.07.013
10.1038/s43018-021-00210-y
10.3389/fimmu.2019.02250
10.3390/cells10040808
10.1126/scitranslmed.3005661
10.4049/jimmunol.1001775
10.1126/sciimmunol.abd5515
10.1126/science.abc8697
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10.1172/jci.insight.99488
10.3389/fmicb.2019.03116
10.1038/nrdp.2016.86
10.3322/caac.21654
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10.1371/journal.pone.0265534
10.1016/j.it.2010.07.003
10.1146/annurev-animal-021419-083831
10.1146/annurev-biochem-063011-092449
10.1093/abt/tbaa001
10.1126/science.1101148
10.1038/s41467-023-44534-y
10.4049/jimmunol.167.9.5420
10.3390/cells9071720
10.1016/j.vaccine.2013.02.065
10.1038/nmeth.3213
10.1038/nprot.2016.169
10.1371/journal.pone.0144787
10.1016/j.ymthe.2018.11.015
10.1038/s41467-023-41631-w
10.1097/HC9.0000000000000022
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10.1038/s41586-021-04061-6
10.1073/pnas.2201433119
10.1074/jbc.M409783200
10.1002/cpps.66
10.1002/cpz1.459
10.1016/j.omto.2022.02.015
|
[
"Duan",
"Li",
"Li",
"Lin",
"Ren",
"Hong",
"Hinrichs",
"Ho"
] |
[
"Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.",
"Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.\nLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
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[] | 9.394915 | 4.922406 |
39523098
| 267 |
[Enhanced tumoricidal activity of PD-1 antibody-secreting c-Met CAR-T cells against pancreatic cancer cells].
|
To construct c-Met CAR-T cells secreting PD-1 antibodies to reduce immune inhibitory effect of tumor cells and enhance the efficacy of CAR-T cell therapy against pancreatic cancer.
Kaplan-Meier Plotter, GEPIA, and Timer 2.0 bioinformatics databases were used to analyze c-Met expression in pancreatic cancer and its correlation with survival and immune infiltration status. In clinical samples of pancreatic cancer and pancreatic cancer Aspc-1 cells, c-Met and PD-L1 expressions were detected using immunohistochemistry or flow cytometry. Using gene editing technology, PD-1 secretory antibodies and HIS tags were linked to second-generation c-Met CAR molecules to construct PD-1/c-Met CAR plasmids, which were then packaged into lentiviruses for infection of activated T cells. The positive rate and cell subset distribution of CAR-T cells were analyzed with flow cytometry, and secretory PD-1 antibodies in cell supernatants were detected using Western blotting. The target cell killing efficiency and proliferative activity of the modified CAR-T cells were evaluated after activation, and cytokine secretion was analyzed using ELISA.
The expression of c-Met was significantly higher in pancreatic cancer than in normal tissues, and its expression level was negatively correlated with the patients' survival and positively correlated with immune cell infiltration. The clinical samples of pancreatic cancer tissues expressed significantly higher levels of c-Met and PD-L1 than the adjacent tissues, and 90.7% and 57.7% of Aspc-1 cells were positive for c-Met and PD-L1, respectively. The constructed PD-1/c-Met CAR-T cells were capable of secreting PD-1 antibodies and showed a significantly higher killing efficiency against tumor cells than c-Met CAR-T cells at an effector-to-target ratio of 20: 1, with also a higher proliferative activity after target cell stimulation and higher levels of IL-2 and TNF-α secretin.
PD-1/c-Met CAR-T cells have higher killing efficiency against pancreatic cancer cells with also higher proliferative activity than c-Met CAR-T cells.
设计并制备能够分泌PD-1抗体和靶向c-Met的CAR-T细胞，以消除肿瘤对CAR-T细胞的免疫抑制作用，从而提高CAR-T细胞对胰腺癌的治疗效果。
采用Kaplan-Meier Plotter、GEPIA和Timer2.0生物信息学数据库，分析c-Met在胰腺癌中的表达、生存期及免疫浸润。免疫组化检测胰腺癌临床样本c-Met和PD-L1表达，流式细胞术验证胰腺癌细胞Aspc-1 c-Met和PD-L1表达通过基因编辑将PD-1分泌型抗体和HIS标签连接至2代c-Met CAR分子后，构建PD-1/c-Met CAR质粒并包被慢病毒，慢病毒感染至活化T细胞内，通过流式细胞技术检测CAR-T阳性率和细胞亚群；Western blotting检测分泌型PD-1抗体在细胞上清液中的存在；体外功能试验中，通过LDH释放实验检测CAR-T对靶细胞的杀伤效率，CCK-8检测靶细胞存在下PD-1抗体对CAR-T增殖的促进作用。ELISA检测PD-1/c-Met CAR-T和c-Met CAR-T活化后细胞因子的分泌量。
生信分析结果显示，胰腺癌组织c-Met表达高于正常组织（
PD-1抗体分泌型c-Met CAR-T可成功构建，并在体外胰腺癌细胞上显示出优于c-Met CAR-T肿瘤杀伤效率和增殖效率。
|
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] | 2024-11-13 | 32 |
39523098
|
[
"Met CAR",
"pancreatic cancer cells",
"pancreatic cancer Aspc-1 cells",
"activated T cells",
"tumor cells",
"Aspc-1 cells",
"immune cell infiltration",
"cell supernatants",
"cell subset",
"Met",
"target cell stimulation",
"pancreatic cancer tissues",
"higher levels",
"higher killing efficiency",
"pancreatic cancer",
"CAR-T cell therapy",
"PD-1 secretory antibodies",
"c-Met CAR-T cells",
"CAR-T cells",
"secretory PD-1",
"proliferative activity",
"c-Met expression",
"PD-1",
"immune inhibitory effect",
"c-Met CAR质粒并包被慢病毒，慢病毒感染至活化T细胞内，通过流式细胞技术检测CAR",
"immune infiltration status",
"c-Met",
"normal tissues",
"the modified CAR-T cells",
"flow cytometry"
] |
[
"c-Met",
"chimeric antigen receptor T-cell therapy",
"pancreatic cancer",
"secretary PD-1 antibody"
] | 0 |
10.12122/j.issn.1673-4254.2024.10.16
|
[
"Min",
"Peng",
"DU",
"An",
"Zhen",
"Cao",
"Zhou",
"Li"
] |
[
"College of Basic Medical Sciecens, Bengbu Medical University, Bengbu 233000, China.",
"College of Basic Medical Sciecens, Bengbu Medical University, Bengbu 233000, China.",
"College of Basic Medical Sciecens, Bengbu Medical University, Bengbu 233000, China.",
"School of Basic Sciences, Bengbu Medical University, Bengbu 233000, China.",
"Clinical Medical College, Bengbu Medical University, Bengbu 233000, China.",
"Clinical Medical College, Bengbu Medical University, Bengbu 233000, China.",
"School of Stomatology, Bengbu Medical University, Bengbu 233000, China.",
"College of Life Sciences, Bengbu Medical University, Bengbu 233000, China."
] |
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[] | 9.892143 | 5.90389 |
39523093
| 268 |
[Modification with IL-21 and CCL19 enhances killing efficiency and tumor infiltration of NKP30 CAR-T cells in lung cancer].
|
To investigate whether modification with IL-21 and CCL19 enhances killing and tumor-infiltrating efficiency of NKP30 CAR-T cells in lung cancer.
The modified IL-21-CCL19 NKP30 CAR-T cells expressing IL-21 and CCL19 fusion gene was constructed based on NKP30 CAR-T cells and stimulated with CD3CD28 antibodies and IL-2. The immunophenotype and migration of the cells in the presence of IL-21 were investigated using flow cytometry and migration experiments. Lactate dehydrogenase (LDH) release and sphere formation assays were used to assess the killing and infiltration capabilities of CAR-T cells, and the secretion levels of IFN-γ, IL-21 and CCL19 were determined with enzyme-linked immunospot assay (ELISPOT) and ELISA. A zebrafish model bearing HCG-27 cell xenograft was established by microinjection of the tumor cells into the yolk sac followed 24 h later by injection of the immune cells at the same site, and the fluorescence signals were captured using a fluorescent microscopy.
The NKP30 ligand B7H6, which was almost undetectable in normal tissues and blood cells, was highly expressed (over 90%) in lung cancer cells. Compared with NKP30 CAR-T cells and conventional T cells, IL-21-CCL19 NKP30 CAR-T cells exhibited stronger proliferative and migration capabilities with the formation of central memory T cells. The reduced expressions of CTLA4 and PD1 in the constructed cells resulted in enhanced killing efficiency against lung cancer cells accompanied by significantly increased production of IFN-γ, IL-21 and CCL19. In the zebrafish models, CAR-T cells exhibited stronger cytotoxicity and proliferative abilities than typical T cells, but these differences were not statistically significant between the two CAR-T cells.
Modification of NKP30 CAR-T cells with IL-21 and CCL19 facilitates their access into solid tumors for more effective tumor cell killing while producing a large number of memory T cells.
探讨细胞因子IL-21和趋化因子CCL19修饰的NKP30 CAR-T细胞是否增强对肺癌的杀伤和浸润作用。
在NKP30 CAR基础上融合基因IL-21和CCL19构建IL-21-CCL19 NKP30 CAR；CAR-T细胞的培养使用CD3CD28单抗及细胞因子IL-2刺激；流式细胞术检测免疫细胞表型；迁移实验检测IL-21对免疫细胞的迁移作用；乳酸脱氢酶（LDH）及成球实验检测CAR-T细胞的杀伤及浸润能力；酶联免疫斑点技术（ELISPOT）检测IFN-γ的分泌数量；ELISA检测IL-21及CCL19的分泌情况；体内实验中，将肿瘤细胞显微注射到斑马鱼卵黄囊，构建斑马鱼移植瘤模型，24 h后将免疫细胞注射至同样部位，体式荧光显微镜拍摄荧光。
NKP30配体（B7H6）在正常组织及血液细胞不表达，在肺癌细胞上高表达（90%以上）。IL-21-CCL19 NKP30 CAR-T细胞与NKP30 CAR-T细胞和常规T细胞相比，具有更强的增殖能力、迁移能力及中心记忆T细胞的形成（
IL-21-CCL19 NKP30 CAR-T细胞更容易浸润到肿瘤内部，有效杀伤肿瘤细胞，同时产生更多的记忆T细胞。
|
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] | 2024-11-13 | 30 |
39523093
|
[
"memory T cells",
"typical T cells",
"conventional T cells",
"central memory T cells",
"lung cancer cells",
"blood cells",
"HCG-27 cell xenograft",
"NKP30 CAR-T cells",
"CCL19",
"IL-21-CCL19 NKP30 CAR-T cells",
"CAR-T cells",
"IL-21",
"more effective tumor cell killing",
"The modified IL-21-CCL19 NKP30 CAR-T cells",
"sphere formation assays",
"the tumor cells",
"solid tumors",
"the constructed cells",
"IL-21 and CCL19 fusion gene",
"the immune cells",
"lung cancer",
"IL-21-CCL19",
"enhanced killing efficiency",
"the cells",
"migration experiments",
"stronger cytotoxicity",
"migration",
"The NKP30 ligand B7H6",
"normal tissues",
"flow cytometry"
] |
[
"CCL19",
"NKP30",
"chimeric antigen receptor gene modified-T lymphocytes",
"interleukin-21",
"lung cancer"
] | 0 |
10.12122/j.issn.1673-4254.2024.10.11
10.12122/j.issn.1673-4254.2023.06.03
|
[
"Zhou",
"Liu",
"Li",
"Chen",
"Lin",
"Chen",
"Chen",
"Lin",
"Zhou",
"Zheng"
] |
[
"Laboratory of Immuno-Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.\nSchool of Basic Medical Sciences, Fujian Medical University, Fuzhou 350100, China.\nFujian Key Laboratory of Translational Cancer Medicine, Fuzhou 350014, China.",
"Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.",
"Laboratory of Immuno-Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.\nSchool of Basic Medical Sciences, Fujian Medical University, Fuzhou 350100, China.\nFujian Key Laboratory of Translational Cancer Medicine, Fuzhou 350014, China.",
"Department of Thoracic Oncology Radiation, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.",
"Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.",
"Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.",
"Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.",
"Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.",
"Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.",
"Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China."
] |
[
"39523093",
"34268421",
"33098993",
"38070118",
"36271832",
"35697295",
"37249661",
"37977064",
"37208608",
"29453518",
"37818365",
"36617554",
"26503962",
"26968708",
"28502785",
"17234735",
"30111631",
"29475789",
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] |
[] | 9.888127 | 5.96807 |
39521782
| 269 |
Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker.
|
A significant challenge for chimeric antigen receptor (CAR) T cell therapy against glioblastoma (GBM) is its immunosuppressive microenvironment, which is densely populated by protumoral glioma-associated microglia and macrophages (GAMs). Myeloid immune checkpoint therapy targeting the CD47-signal regulatory protein alpha (SIRPα) axis induces GAM phagocytic function, but CD47 blockade monotherapy is associated with toxicity and low bioavailability in solid tumors. In this work, we engineer a CAR T cell against epidermal growth factor receptor variant III (EGFRvIII), constitutively secreting a signal regulatory protein gamma-related protein (SGRP) with high affinity to CD47. Anti-EGFRvIII-SGRP CAR T cells eradicate orthotopic EGFRvIII-mosaic GBM in vivo, promoting GAM-mediated tumor cell phagocytosis. In a subcutaneous CD19
|
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] | 2024-11-13 | 76 |
39521782
|
[
"T cell therapy",
"epidermal growth factor receptor",
"chimeric antigen receptor",
"GAM phagocytic function",
"Myeloid immune checkpoint therapy",
"CD47 blockade monotherapy",
"Anti-EGFRvIII-SGRP CAR T cells",
"GAM-mediated tumor cell phagocytosis",
"solid tumors",
"GBM",
"a CAR T cell",
"variant III",
"low bioavailability",
"CD47",
"high affinity",
"a signal regulatory protein gamma-related protein",
"protumoral glioma-associated microglia",
"toxicity",
"SGRP",
"CAR",
"vivo",
"SIRPα",
"glioblastoma",
"macrophages",
"GAMs",
"Myeloid",
"its immunosuppressive microenvironment",
"EGFRvIII-mosaic GBM",
"A significant challenge",
"a subcutaneous CD19"
] |
[] | 0 |
10.1038/s41467-024-54129-w
|
[
"Martins",
"Kaymak",
"Tatari",
"Gerster",
"Hogan",
"Ritz",
"Sabatino",
"Wieboldt",
"Bartoszek",
"McDaid",
"Gerber",
"Buck",
"Beshirova",
"Heider",
"Shekarian",
"Mohamed",
"Etter",
"Schmassmann",
"Abel",
"Boulay",
"Saito",
"Mariani",
"Guzman",
"Snijder",
"Weiss",
"Läubli",
"Hutter"
] |
[
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland. tomas.martins@unibas.ch.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Cancer Immunotherapy, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Microscopy Core Facility, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.\nDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.\nDepartment of Neurology, University of Zurich, Zurich, Switzerland.",
"Experimental Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos Wolfgang, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.",
"Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.",
"Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.\nDepartment of Surgery, University Hospital Basel, Basel, Switzerland.",
"Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.\nDepartment of Surgery, University Hospital Basel, Basel, Switzerland.",
"Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.",
"Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.\nDepartment of Neurology, University of Zurich, Zurich, Switzerland.",
"Cancer Immunotherapy, Department of Biomedicine, University of Basel, Basel, Switzerland.\nDepartment of Oncology, University Hospital Basel, Basel, Switzerland.",
"Brain Tumor Immunotherapy and Biology, Department of Biomedicine, University of Basel, Basel, Switzerland. gregor.hutter@usb.ch.\nDepartment of Neurosurgery, University Hospital Basel, Basel, Switzerland. gregor.hutter@usb.ch.\nDepartment of Surgery, University Hospital Basel, Basel, Switzerland. gregor.hutter@usb.ch."
] |
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] |
[] | 10.017225 | 7.2992 |
39520682
| 270 |
TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens.
|
Targeting tumor-specific neoantigens holds promise for cancer immunotherapy, but their ultra-low expression on tumor cells poses challenges for T cell therapies. Here, we found that chimeric antigen receptors (CARs) exhibit 10-100 times lower sensitivity than T cell receptors (TCRs) when targeting human leukocyte antigen (HLA) class I-presented p53
|
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] | 2024-11-13 | 1 |
39520682
|
[
"chimeric antigen receptors",
"tumor cells",
"cancer immunotherapy",
"T cell receptors",
"their ultra-low expression",
"promise",
"CARs",
"T cell therapies",
"TCRs",
"tumor-specific neoantigens",
"challenges",
"10-100 times lower sensitivity",
"10-100",
"we"
] |
[
"CAR",
"CP: Immunology",
"STAR",
"T cell receptor",
"TCR",
"antigen sensitivity",
"cancer immunotherapy",
"chimeric antigen receptor",
"neoantigen",
"synthetic TCR and antigen receptor",
"synthetic receptor"
] | 0 |
10.1016/j.celrep.2024.114949
|
[
"Huang",
"Li",
"Rui",
"Sun",
"Zhou",
"Lv",
"Yu",
"Chen",
"Zhou",
"Liu",
"Wang",
"Lan",
"Fu",
"Zhao",
"Lin"
] |
[
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute for Immunology, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute for Immunology, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute for Immunology, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute for Immunology, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.",
"Changping Laboratory, Beijing 102206, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute for Immunology, Tsinghua University, Beijing 100084, China.",
"Changping Laboratory, Beijing 102206, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute for Immunology, Tsinghua University, Beijing 100084, China.",
"School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute for Immunology, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Changping Laboratory, Beijing 102206, China. Electronic address: linxin307@tsinghua.edu.cn."
] |
[
"39520682"
] |
[] | 8.942007 | 5.038275 |
39518068
| 271 |
Membrane Antigen Targeting in Acute Myeloid Leukemia Using Antibodies or CAR-T Cells.
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This review explores the emerging area of the therapeutic use of antibodies and chimeric antigen receptor (CAR)-T cells for the treatment of acute myeloid leukemia (AML). Through a detailed analysis of the existing literature, this paper highlights the different categories of AML antigens for immunotherapeutic targeting, the most recent applications on antibodies, including bispecific immune cell engagers and CAR-T cells, to the therapy of patients with refractory/relapsing AML The studies performed in AML patients using BisAbs and CAR-T cells have shown that only a limited number of AML patients show sustained responses to these therapies, thus underlying AML heterogeneity as a major challenge. Several studies have addressed the potential mechanisms underlying the resistance of AMLs to antibody-directed immunotherapies. A better understanding of the barriers hampering the successful development of AML immunotherapy is required. However, in spite of the limitations, the studies recently carried out have shown the peculiar sensitivity of some AML subtypes to immunotherapy and have provided the basis for future studies, such as multiplex antigen targeting, which hold the promise of successful development.
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39518068
|
[
"AML patients",
"AML immunotherapy",
"AML heterogeneity",
"AML",
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"future studies",
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"successful development",
"antibodies",
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"AMLs",
"BisAbs",
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"myeloid",
"refractory",
"the successful development",
"spite",
"The studies",
"the studies"
] |
[
"acute myeloid leukemia",
"bispecific antibodies",
"chimeric antigen receptor T cells",
"immunologic profile",
"immunotherapy",
"membrane antigens",
"monoclonal antibodies"
] | 0 |
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|
[
"Testa",
"Castelli",
"Pelosi"
] |
[
"Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.",
"Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.",
"Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy."
] |
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[] | 6.840625 | 7.173132 |
39516088
| 272 |
BCMA-Directed MRD Detection as a Predictor of Relapse after BCMA CAR T in Multiple Myeloma.
|
Recent approvals of chimeric antigen receptor T-cells (CAR T) and bispecific antibody therapies offer new hope for relapsed refractory multiple myeloma (RRMM) patients, with superior efficacy over standard regimens observed in clinical trials. However, relapse after BCMA-directed therapy is common and requires further investigation.
We conducted a retrospective cohort study on 57 RRMM patients treated with BCMA-directed CAR T. Only the patients who had an initial response and lost BCMA-expressing identified PC following CAR T infusion at Day 30 were included in the analysis. Multicolor flow cytometry (MFC) to detect BCMA + plasma cell (PC) re-emergence was performed on bone marrow samples at defined intervals and clinical responses were assessed using International Myeloma Working Group criteria.
The majority of patients achieved undetectable BCMA on MFC postinfusion, with subsequent BCMA+ PC re-emergence observed in 55% of cases. Notably, 91% of patients experiencing clinical relapse showed BCMA+ PC re-emergence, often preceding relapse. Early relapse (<6 months) was associated with earlier BCMA re-emergence.
Early BCMA+ PC re-emergence may serve as a prognostic marker for clinical relapse post-BCMA CAR T therapy. Monitoring BCMA+ PC levels via MFC offers potential for early relapse detection and informed treatment decisions. Further studies, including novel BCMA-directed minimal residual disease (MRD) detection technologies, are warranted to validate these findings and refine RRMM management strategies.
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] | 2024-11-13 | 1 |
39516088
|
[
"earlier BCMA re",
"clinical relapse post-BCMA CAR T therapy",
"subsequent BCMA+ PC re",
"clinical relapse",
"early relapse detection",
"Early relapse",
"BCMA",
"clinical responses",
"CAR T infusion",
"PC levels",
"patients",
"re",
"relapse",
"PC",
"-",
"clinical trials",
"emergence",
"bispecific antibody therapies",
"MFC postinfusion",
"CAR T",
"International Myeloma Working Group criteria",
"International Myeloma Working Group",
"novel BCMA-directed minimal residual disease",
"RRMM management strategies",
"BCMA-expressing identified PC",
"Further studies",
"MFC",
"BCMA-directed CAR",
"plasma cell",
"BCMA-directed therapy"
] |
[
"BCMA",
"CAR T",
"Chimeric antigen receptor therapy",
"Flow cytometry",
"Minimal residual disease",
"Myeloma"
] | 0 |
10.1016/j.clml.2024.10.003
|
[
"Rashid",
"Wesson",
"Abdallah",
"Snyder",
"Venkatesh",
"Mushtaq",
"Shune",
"Witek",
"McGuirk",
"Soper",
"Cui",
"Ahmed"
] |
[
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS; United States Myeloma Innovations Research Collaborative (USMIRC), Westwood, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS; United States Myeloma Innovations Research Collaborative (USMIRC), Westwood, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS; United States Myeloma Innovations Research Collaborative (USMIRC), Westwood, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS; United States Myeloma Innovations Research Collaborative (USMIRC), Westwood, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS; United States Myeloma Innovations Research Collaborative (USMIRC), Westwood, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS.",
"Kansas Institute for Precision Medicine, University of Kansas Medical Center, Kansas City, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS.",
"Kansas Institute for Precision Medicine, University of Kansas Medical Center, Kansas City, KS.",
"Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS.",
"Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS; United States Myeloma Innovations Research Collaborative (USMIRC), Westwood, KS. Electronic address: nahmed5@kumc.edu."
] |
[
"39516088"
] |
[] | 5.051077 | 5.853106 |
39514948
| 273 |
Preclinical assessment of the efficacy of B7-H3 CAR-T in renal cell carcinoma.
|
B7-H3 is a type I transmembrane protein that belongs to the B7 immune checkpoint protein family, is aberrantly expressed in cancer cells, but rarely expressed in normal tissues, making it an attractive target for cancer therapy. Here, we found B7-H3 is highly expressed in the renal cell carcinoma (RCC) tumor tissues and RCC cell lines, but is undetectable in normal renal tissues. Therefore, we engineered second-generation CAR-T cells targeting B7-H3, incorporating either CD28 or 4-1BB co-stimulatory domains. Both CAR-T cell variants demonstrated potent antitumor activity against RCC tumors in vitro and in metastatic and orthotopic RCC mouse models. Furthermore, the B7-H3 CAR-T cells exhibited remarkable proliferation and robust cytokine release when co-cultured with RCC cancer cells. These findings demonstrated that targeting B7-H3 by CAR-T cells potentially offering a new treatment option for RCC patients.
|
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] | 2024-11-13 | 44 |
39514948
|
[
"RCC cancer cells",
"RCC cell lines",
"cancer cells",
"RCC tumors",
"RCC patients",
"normal renal tissues",
"RCC",
"B7",
"normal tissues",
"robust cytokine release",
"cancer therapy",
"CAR-T cells",
"potent antitumor activity",
"the B7 immune checkpoint protein family",
"the renal cell carcinoma",
"remarkable proliferation",
"metastatic and orthotopic RCC mouse models",
"transmembrane protein",
"B7-H3",
"second-generation CAR-T cells",
"the B7-H3 CAR-T cells",
"Both CAR-T cell variants",
"(RCC) tumor tissues",
"second",
"a new treatment option",
"4-1BB co-stimulatory domains",
"either CD28",
"These findings",
"a type",
"4-1BB"
] |
[
"B7-H3",
"CAR-T",
"Renal cell carcinoma"
] | 0 |
10.1016/j.molimm.2024.10.006
|
[
"Li",
"Wang",
"Zhao",
"Cao",
"Wang",
"Li",
"Savoldo",
"Rao",
"Dotti",
"Du"
] |
[
"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.",
"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.",
"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.",
"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.",
"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101125, China.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA.",
"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: gdotti@med.unc.edu.",
"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address: hwdu@xzhmu.edu.cn."
] |
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[] | 10.112213 | 6.613002 |
39514017
| 274 |
The mechanisms of B-cell acute lymphoblastic leukemia relapsing following chimeric antigen receptor-T cell therapy; the plausible future strategies.
|
Research has demonstrated the high mortality and morbidity associated with B-Acute lymphoblastic lymphoma (B-ALL). Researchers have developed several therapeutic approaches to combat the disorder. Recently, researchers developed chimeric antigen receptors (CARs)-T cells, which recognize antigens independently of major histocompatibility complexes (MHCs) and activate at a higher level with additional persistence. However, relapsing B-ALL has been reported in several cases. This review article was aimed to collecting recent information regarding the mechanisms used by B-ALL-related lymphocytes to escape from CAR-T cells and the plausible resolution projects.
|
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39514017
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] |
[
"B-Acute lymphoblastic lymphoma",
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"Relapsing"
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10.1007/s11033-024-10061-2
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|
[
"Karimi-Googheri",
"Gholipourmalekabadi",
"Madjd",
"Shabani",
"Rostami",
"Kazemi Arababadi",
"Kiani"
] |
[
"Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.\nDepartment of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.\nApplied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.",
"Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.\nDepartment of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.",
"Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.\nDepartment of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.",
"Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.",
"Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.",
"Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. drkazemi@rums.ac.ir.\nDepartmant of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. drkazemi@rums.ac.ir.",
"Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Ja.kiani@gmail.com."
] |
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[] | 6.711766 | 6.337069 |
39512355
| 275 |
Targeting TGFβ with chimeric switch receptor and secreted trap to improve T cells anti-tumor activity.
|
TGFβ is a major immunoinhibitory factor present in the microenvironment of solid tumors. Various cancer types acquire the ability to overexpress TGFβ to escape immune response. Specifically, TGFβ dampens cytotoxic T cell activity, and its presence has been correlated with tumor invasion and poor prognosis.
In this study, we developed two approaches to counteract the effects of TGFβ and provide a functional advantage to genetically engineered T cells in the immunoinhibitory tumor milieu. We designed a TGFβRI-based co-stimulatory switch receptor (CSRI), comprising the TGFβ receptor I extracellular binding domain and a 4-1BB co-stimulatory signaling moiety. Additionally, we tested the efficacy of a TGFβ-binding scFv trap produced by T cells.
We demonstrated that both approaches enhanced tumor-specific T cell cytokine secretion, upregulated activation markers, and reduced inhibition markers upon co-culture with melanoma targets. Furthermore, CSRI and the anti-TGFβ trap exhibited improved anti-tumor function
Overall, we show that targeting the TGFβ pathway can enhance cellular immunotherapy.
|
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39512355
|
[
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"tumor invasion",
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"the TGFβ pathway",
"TGFβRI",
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"the effects"
] |
[
"T cells",
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10.3389/fimmu.2024.1460266
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10.1186/s13045-021-01053-x
10.1016/j.cell.2020.03.039
10.1126/sciadv.abi5781
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10.1182/blood-2009-01-199216
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10.1016/j.omto.2021.03.014
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10.1136/jitc-2023-008434
10.1016/j.ymthe.2024.05.006
10.1038/sj.bjc.6605642
|
[
"Matikhina",
"Cohen"
] |
[
"The Laboratory of Tumor Immunology and Immunotherapy, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"The Laboratory of Tumor Immunology and Immunotherapy, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel."
] |
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[] | 10.670856 | 4.949643 |
39511890
| 276 |
Proton pump inhibitor attenuates acidic microenvironment to improve the therapeutic effects of MSLN-CAR-T cells on the brain metastasis.
|
The incidence of brain metastasis (BM) is gradually increasing, and the prognosis and therapeutic effect are poor. The emergence of immunotherapy has brought hope for the development of BM treatments. This study revealed that compared with primary cancers, BMs have a colder and more acidic tumor microenvironment (TME), resulting in reduced protein levels of mesothelin (MSLN), a promising target for chimeric antigen receptor-T (CAR-T) cell therapy for triple-negative breast cancer (TNBC) with BMs. These factors could significantly decrease the efficiency of MSLN-CAR-T cells in TNBC BMs. Pantoprazole (PPZ) administration at the most commonly used dose in the clinic notably increased the pH of the TME, inhibited lysosomal activity, increased the membrane levels of the MSLN protein and improved the killing ability of MSLN-CAR-T cells both in vitro and in vivo. Similar results were obtained in non-small cell lung cancer BMs. Hence, when administered in combination with CAR-T cells, PPZ, which increases the protein levels of target antigens, may constitute a new immunotherapeutic strategy for treating solid tumors with BMs.
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] | 2024-11-13 | 1 |
39511890
|
[
"non-small cell lung cancer BMs",
"reduced protein levels",
"TNBC BMs",
"target antigens",
"primary cancers",
"MSLN",
"BMs",
"BM treatments",
"solid tumors",
"inhibited lysosomal activity",
"BM",
"CAR-T cells",
"TME",
"MSLN-CAR-T cells",
"brain metastasis",
"PPZ",
"Similar results",
"hope",
"triple-negative breast cancer",
"the MSLN protein",
"TNBC",
"the protein levels",
"immunotherapy",
"CAR-T",
"more acidic tumor microenvironment",
"mesothelin",
"the membrane levels",
"a new immunotherapeutic strategy",
"combination",
"a promising target"
] |
[
"adoptive cell therapy",
"brain metastases",
"chimeric antigen receptor T cells",
"immunotherapy",
"mesothelin",
"pantoprazole",
"solid tumor",
"tumor microenvironment"
] | 0 |
10.1016/j.ymthe.2024.11.010
|
[
"Zhai",
"Mao",
"Kang",
"Liu",
"Zhou",
"Wang",
"Yang",
"Wang",
"Wang",
"Li",
"Duan",
"Zhang",
"Lin",
"Zhao",
"Li",
"Wu",
"Yu"
] |
[
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Department of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Breast and Thyroid Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address: wumin0517wu@163.com.",
"Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China. Electronic address: yushicang@163.com."
] |
[
"39511890"
] |
[] | 10.113868 | 5.883801 |
39510106
| 277 |
Accelerating and optimising CAR T-cell manufacture to deliver better patient products.
|
Autologous chimeric antigen receptor (CAR) T-cell therapy has transformed the management of B-cell leukaemia and lymphoma. However, current manufacturing processes present logistical hurdles, restricting broader application. As clinical outcomes can be heavily influenced by the quality of autologous starting materials and production processes, strategies to improve product phenotype are crucial. Short manufacturing processes have the advantage of bringing products to patients more quickly and, in parallel, avoiding the highly differentiated and exhausted CAR T-cell phenotypes associated with prolonged ex vivo manufacture. This Review examines advances in our understanding of what constitutes an effective CAR T-cell product and approaches to improve product quality. Historically, strategies have relied on adjustments in medium composition and selection of less differentiated cell subtypes. Since 2020, the field has been shifting towards reduced-expansion protocols, no-activation protocols, and point-of-care manufacturing. These approaches have the advantage of a rapid turnaround while maintaining a less differentiated and exhausted phenotype. These efforts are leading to ultrarapid production methods and even elimination of ex vivo manipulation with the use of in vivo manufacturing approaches. In this Review, we focus on the advances needed to accelerate CAR T-cell manufacture (including near-patient methods), with an emphasis on improved therapeutic efficacy and rapid turnaround time, and simplified quality control procedures required to fully realise the clinical potential of CAR T-cell therapies.
|
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] | 2024-11-13 | 1 |
39510106
|
[
"current manufacturing processes",
"Short manufacturing processes",
"product quality",
"vivo manufacturing approaches",
"product phenotype",
"ultrarapid production methods",
"prolonged ex vivo manufacture",
"rapid turnaround time",
"CAR T-cell therapies",
"CAR T-cell manufacture",
"quality control procedures",
"improved therapeutic efficacy",
"ex vivo manipulation",
"Autologous chimeric antigen receptor",
"products",
"logistical hurdles",
"autologous starting materials and production processes",
"clinical outcomes",
"medium composition",
"CAR) T-cell therapy",
"less differentiated cell subtypes",
"B-cell leukaemia",
"patients",
"advances",
"approaches",
"an effective CAR T-cell product",
"broader application",
"strategies",
"the highly differentiated and exhausted CAR T-cell phenotypes",
"near-patient methods"
] |
[] | 0 |
10.1016/S2352-3026(24)00273-4
|
[
"Agliardi",
"Dias",
"Rampotas",
"Garcia",
"Roddie"
] |
[
"Cancer Institute, University College London, London, UK; Centre for Cell, Gene and Tissue Therapeutics, Royal Free Hospital London, NHS Foundation Trust, London, UK.",
"Cancer Institute, University College London, London, UK; Centre for Cell, Gene and Tissue Therapeutics, Royal Free Hospital London, NHS Foundation Trust, London, UK.",
"Cancer Institute, University College London, London, UK; Department of Haematology, University College London Hospitals, London, UK.",
"Cancer Institute, University College London, London, UK; Centre for Cell, Gene and Tissue Therapeutics, Royal Free Hospital London, NHS Foundation Trust, London, UK.",
"Cancer Institute, University College London, London, UK; Department of Haematology, University College London Hospitals, London, UK. Electronic address: c.roddie@ucl.ac.uk."
] |
[
"39510106"
] |
[] | 8.581795 | 3.149287 |
39509090
| 278 |
Equecabtagene Autoleucel in Patients With Relapsed or Refractory Multiple Myeloma: The FUMANBA-1 Nonrandomized Clinical Trial.
|
Equecabtagene autoleucel (eque-cel), a fully human-derived B-cell maturation antigen-targeting chimeric antigen receptor (CAR) T-cell therapy, has exhibited potential for the treatment of relapsed or refractory multiple myeloma (RRMM), and further investigation in a larger cohort is necessary.
To evaluate whether eque-cel can benefit patients with RRMM and determine the overall response rate postinfusion.
The FUMANBA-1 trial was a single-arm, open-label, phase 1b/2 trial that evaluated eque-cel in adult patients with RRMM. Enrollment began in April 2020, and patients who received eque-cel will be monitored for a minimum of 15 years following the infusion. As of September 2022, patients with heavily pretreated RRMM who received at least 3 prior courses of therapy from 14 centers were enrolled. Data were analyzed from April 2020 to September 2022.
Patients received a single infusion of eque-cel at 1.0 × 106 CAR-positive T cells/kg after the lymphodepletion.
Efficacy was the primary objective, and safety, pharmacokinetics, and pharmacodynamics were secondary objectives.
Of 103 patients who received an eque-cel infusion, 55 (53.4%) were male, and the median (range) age was 58 (39-70) years. A total of 101 patients were evaluable for efficacy. At a median (range) follow-up of 13.8 (0.4-27.2) months, the overall response rate was 96.0% (97 of 101), with 74.3% (75 of 103) achieving a complete response or better. Among the 12 patients who had prior CAR T-cell treatment, 75% (9 of 12) achieved a response. The median progression-free survival was not reached, with a 12-month progression-free survival rate of 78.8% (95% CI, 68.6-86.0). A total of 96 patients (95.0%) achieved minimal residual disease negativity at a sensitivity threshold of 10-5. Adverse events were favorable: 96 of 103 patients (93.2%) experienced cytokine release syndrome (grade 1 to 2 in 95 patients [92.3%]) and 2 (1.9%) experienced immune effector cell-associated neurotoxicity syndrome (grade 1 to 2). All cases of immune effector cell-associated neurotoxicity syndrome and 94 of 96 cases of cytokine release syndrome resolved with treatment. Additionally, only 20 patients (19.4%) developed antidrug antibodies. Cellular kinetic analysis confirmed CAR-positive T cells in all patients, with the longest duration at 735 days.
In this trial, eque-cel led to early, deep, and durable responses in patients with heavily pretreated RRMM with a manageable safety profile. Patients with prior CAR T-cell therapy also benefitted from eque-cel.
Chinese Clinical Trial Registry Identifier: ChiCTR2000033946.
|
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] | 2024-11-13 | 28 |
39509090
|
[
"Patients",
"patients",
"adult patients",
"prior CAR T-cell therapy",
"prior CAR T-cell treatment",
"Chinese Clinical Trial Registry Identifier",
"experienced immune effector cell-associated neurotoxicity syndrome",
"immune effector cell-associated neurotoxicity syndrome",
"cytokine release syndrome",
"CAR-positive T cells",
"minimal residual disease negativity",
"RRMM",
"therapy",
"further investigation",
"secondary objectives",
"eque-cel",
"safety",
"treatment",
"the overall response rate postinfusion",
"95% CI",
"Cellular kinetic analysis",
"101 patients",
"103 patients",
"95 patients",
"96 patients",
"all patients",
"the overall response rate",
"an eque-cel infusion",
"months",
"1.9%"
] |
[] | 0 |
10.1001/jamaoncol.2024.4879
10.1056/NEJMra1011442
10.1111/bjh.14213
10.1016/j.annonc.2020.11.014
10.1038/s41375-022-01531-2
10.1038/s41571-020-0427-6
10.1016/S1470-2045(19)30788-0
10.1016/S0140-6736(21)00933-8
10.1056/NEJMoa2024850
10.1056/NEJMoa2203478
10.1038/s41591-023-02528-9
10.1182/blood.2020008936
10.1182/blood.2021010833
10.1182/blood-2010-10-299487
10.1038/leu.2015.290
10.1016/S1470-2045(16)30206-6
10.1182/blood-2014-05-552729
10.3389/fimmu.2021.755866
10.1200/JCO.21.01676
10.1182/blood.2022017848
10.1016/j.bbmt.2018.12.758
10.1016/S2352-3026(19)30115-2
10.1182/blood.2020006216
10.1016/j.jtct.2021.03.004
10.1038/s41408-021-00563-8
10.1053/j.seminhematol.2023.02.003
10.1111/cts.13421
10.1200/JCO.22.00690
|
[
"Li",
"Zhou",
"Hu",
"Zou",
"Chen",
"Chen",
"Liu",
"Zhang",
"Ren",
"Hu",
"Liu",
"Mi",
"Li",
"Ding",
"Wang",
"Wang",
"Cai",
"Li",
"Song",
"Huang",
"Qiu"
] |
[
"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.\nKey Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.\nImmunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, China.",
"Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University and the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.",
"Department of Hematology, Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.",
"National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.",
"Department of Hematology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.",
"Department of Hematology, Nanjing University Medical School, the Affiliated Nanjing Drum Tower Hospital, Nanjing, China.",
"Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China.",
"Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China.",
"Department of Hematology, Peking University First Hospital, Beijing, China.",
"Department of Adult Lymphoma, Beijing GoBroad Boren Hospital, Beijing, China.",
"Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China.",
"State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Shanghai Institute of Hematology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.",
"The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.",
"Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.",
"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.\nImmunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, China.",
"Nanjing IASO Medical Technology Co, Nanjing, China.",
"Nanjing IASO Medical Technology Co, Nanjing, China.",
"Department of Hematology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.",
"Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University and the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.",
"Department of Hematology, Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.",
"National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China."
] |
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] |
[] | 5.238643 | 5.736145 |
39507317
| 279 |
Point-of-care manufacturing of anti-CD19 CAR-T cells using a closed production platform: Experiences of an academic in Thailand.
|
Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has evolved as a standard of care for various forms of relapsed/refractory B cell malignancies in major developed countries. However, access to industry-driven CAR-T cell therapy is limited in developing countries, partly due to the centralized manufacturing system. Here, we demonstrated the feasibility of the point-of-care (POC) manufacturing of anti-CD19 CAR-T cells from heavily pretreated patients and healthy graft donors at an academic medical center in Thailand using a closed semi-automated production platform, CliniMACS Prodigy, and established in-process quality control and release testing to ensure their identity, purity, sterility, safety, and potency. Nine out of the nine products manufactured were used in a pilot study (ISRCTN17901467). However, we did observe that starting T cells with CD4/CD8 ratios of less than one-third had a high chance of manufacturing failure, which could be minimized by serum supplementation. Further analysis of T cell phenotypes in the infused versus circulating CAR-T cells revealed the differentiation from early memory subtypes toward effector cells
|
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] | 2024-11-12 | 33 |
39507317
|
[
"CAR)-T cell therapy",
"effector cells",
"anti-CD19 CAR-T cells",
"circulating CAR-T cells",
"T cell phenotypes",
"major developed countries",
"manufacturing failure",
"relapsed/refractory B cell malignancies",
"developing countries",
"T cells",
"healthy graft donors",
"industry-driven CAR-T cell therapy",
"early memory subtypes",
"CliniMACS Prodigy",
"care",
"a closed semi-automated production platform",
"various forms",
"serum supplementation",
"purity",
"testing",
"process",
"Further analysis",
"sterility",
"Thailand",
"CAR)-T",
"safety",
"an academic medical center",
"CD4/CD8 ratios",
"the centralized manufacturing system",
"potency"
] |
[
"B cell malignancies",
"CAR",
"CAR-T cells",
"CD19",
"MT: Regular Issue",
"POC",
"Thailand",
"automated",
"chimeric antigen receptor",
"manufacturing",
"point-of-care"
] | 0 |
10.1016/j.omton.2024.200889
|
[
"Luanpitpong",
"Klaihmon",
"Janan",
"Kungwankiattichai",
"Owattanapanich",
"Kunacheewa",
"Chanthateyanonth",
"Donsakul",
"U-Pratya",
"Warindpong",
"Kittivorapart",
"Permpikul",
"Issaragrisil"
] |
[
"Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nSiriraj Cell Factory for Cancer Immunotherapy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nBlood Products and Cellular Immunotherapy Research Group, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nSiriraj Cell Factory for Cancer Immunotherapy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nSiriraj Cell Factory for Cancer Immunotherapy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nBlood Products and Cellular Immunotherapy Research Group, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nCenter of Excellence of Siriraj Adult Acute Myeloid/Lymphoblastic Leukemia, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nCenter of Excellence of Siriraj Adult Acute Myeloid/Lymphoblastic Leukemia, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nCenter of Excellence of Siriraj Adult Acute Myeloid/Lymphoblastic Leukemia, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nSiriraj Cell Factory for Cancer Immunotherapy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nCenter of Excellence of Siriraj Adult Acute Myeloid/Lymphoblastic Leukemia, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.",
"Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nDivision of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.\nBDMS Center of Excellence for Hematology, Wattanosoth Cancer Hospital, Bangkok 10310, Thailand."
] |
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] |
[] | 8.55295 | 3.100773 |
39506012
| 280 |
Acute kidney injury in hematological patients treated with CAR-T cells: risk factors, clinical presentation and impact on outcomes.
|
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematologic malignancies, yet it carries significant risks, including acute kidney injury (AKI). In this study, we investigated the risk factors and clinical impact of AKI in patients undergoing CAR-T cell therapy. This retrospective study involved hematologic patients treated with CAR-T therapy. Clinical and laboratory data were collected, and clinical outcomes were monitored during follow-up after CAR-T infusion. AKI was defined according to KDIGO criteria. The outcome measures included early mortality, overall survival (OS), and disease-free survival (DFS). Among the 48 patients analyzed, 14 (29%) developed AKI, with a mean onset of 6 days after CAR-T infusion. The risk of AKI was associated with baseline performance status (OR 8.65, IC95% 6.2-12, p = 0.032) and the development of severe cytokine release syndrome post-therapy (OR 16.4 95%CI 1.9-138.5, p = 0.01). Patients with AKI more frequently required intensive care. Furthermore, severe AKI was independently associated with worse clinical outcomes, including reduced OS and DFS (HR 18.2, 95%CI 2.6-27.3, p = 0.003). Additionally, patients who developed AKI post-CAR-T therapy were more likely to progress to chronic kidney disease during follow-up. In conclusion, frail patients undergoing CAR-T therapy are at an increased risk of developing AKI, which can significantly affect both short- and long-term outcomes. Preventive strategies and early recognition of AKI are essential in these patients.
|
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] | 2024-11-07 | 37 |
39506012
|
[
"AKI",
"hematologic patients",
"worse clinical outcomes",
"clinical outcomes",
"frail patients",
"therapy",
"AKI post-CAR-T therapy",
"Patients",
"patients",
"significant risks",
"clinical impact",
"CAR-T cell therapy",
"severe cytokine release syndrome post",
"CAR-T therapy",
"chronic kidney disease",
"early mortality",
"early recognition",
"severe AKI",
"hematologic malignancies",
"IC95%",
"baseline performance status",
"CAR-T infusion",
"p",
"overall survival",
"acute kidney injury",
"reduced OS",
"KDIGO criteria",
"DFS",
"Preventive strategies",
"intensive care"
] |
[
"Acute kidney injury",
"CAR-T cell therapy",
"Cytokine release syndrome",
"Disease-free survival",
"Mortality",
"Performance status"
] | 0 |
10.1038/s41598-024-77720-z
|
[
"Russo",
"Gambella",
"Raiola",
"Beltrametti",
"Zanetti",
"Chirco",
"Viazzi",
"Angelucci",
"Esposito"
] |
[
"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Genova, Italy.\nUnit of Nephrology, Dialysis and Transplantation, IRCCS Ospedale Policlinico San Martino, Genova, Italy.",
"Unit of Hematology and Cellular Therapy, IRCCS Ospedale Policlinico San Martino, Genova, Italy.",
"Unit of Hematology and Cellular Therapy, IRCCS Ospedale Policlinico San Martino, Genova, Italy.",
"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Genova, Italy.",
"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Genova, Italy.",
"Unit of Nephrology, Dialysis and Transplantation, IRCCS Ospedale Policlinico San Martino, Genova, Italy.",
"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Genova, Italy.\nUnit of Nephrology, Dialysis and Transplantation, IRCCS Ospedale Policlinico San Martino, Genova, Italy.",
"Unit of Hematology and Cellular Therapy, IRCCS Ospedale Policlinico San Martino, Genova, Italy.",
"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Genova, Italy. pasquale.esposito@unige.it.\nUnit of Nephrology, Dialysis and Transplantation, IRCCS Ospedale Policlinico San Martino, Genova, Italy. pasquale.esposito@unige.it."
] |
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[] | 5.936442 | 4.20763 |
39504968
| 281 |
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP.
|
Elucidating mechanisms of T cell development can guide in vitro T cell differentiation from induced pluripotent stem cells (iPSCs) and facilitate off-the-shelf T cell-based immunotherapies. Using a stroma-free human iPSC-T cell differentiation platform, we screened for epigenetic modulators that influence T cell specification and identified the H3K9-directed histone methyltransferases G9a/GLP as repressors of T cell fate. We show that G9a/GLP inhibition during specific time windows of differentiation of hematopoietic stem and progenitor cells (HSPCs) skews cell fates toward lymphoid lineages. Inhibition of G9a/GLP promotes the production of lymphoid cells during zebrafish embryonic hematopoiesis, demonstrating the evolutionary conservation of G9a/GLP function. Importantly, chemical inhibition of G9a/GLP facilitates the generation of mature iPSC-T cells that bear transcriptional similarity to peripheral blood αβ T cells. When engineered to express chimeric antigen receptors, the epigenetically engineered iPSC-T cells exhibit enhanced effector functions in vitro and durable, persistent antitumor activity in a xenograft tumor-rechallenge model.
|
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] | 2024-11-07 | 54 |
39504968
|
[
"lymphoid cells",
"progenitor cells",
"skews cell",
"induced pluripotent stem cells",
"mature iPSC-T cells",
"peripheral blood αβ T cells",
"T cell development",
"T cell fate",
"T cell specification",
"enhanced effector functions",
"differentiation",
"hematopoietic stem",
"zebrafish embryonic hematopoiesis",
"specific time windows",
"chimeric antigen receptors",
"vitro T cell differentiation",
"a stroma-free human iPSC-T cell differentiation platform",
"chemical inhibition",
"lymphoid lineages",
"transcriptional similarity",
"Inhibition",
"epigenetic modulators",
"G9a/GLP inhibition",
"T cell-based immunotherapies",
"G9a/GLP function",
"the epigenetically engineered iPSC-T cells",
"G9a/GLP",
"H3K9",
"methyltransferases",
"iPSCs"
] |
[
"CAR-T cells",
"G9a/GLP",
"T cell differentiation",
"cancer immunotherapy",
"chemical screen",
"epigenetic regulation",
"hematopoiesis",
"lymphoid development",
"pluripotent stem cells"
] | 0 |
10.1016/j.stem.2024.10.004
10.1038/s41408-021-00459-7
10.1038/s41586-023-06243-w
10.1111/trf.14110
10.1038/nbt.2678
10.1038/nature25435
10.1016/j.stem.2022.06.014
10.1016/j.stem.2013.09.002
10.1126/scitranslmed.aah5645
10.1177/108705719900400206
10.1038/s41467-020-20658-3
10.1038/ncb3161
10.1101/gad.1284005
10.1016/j.jbc.2021.101276
10.1038/ng.3646
10.1038/nil007
10.1242/dev.012385
10.1016/sl074-7613(03)00328-5
10.1182/blood-2012-06-440065
10.1038/ncommslll71
10.1016/s0092-8674(00)81929-7
10.1016/sl044-5323(03)00007-l
10.1016/j.immuni.2005.04.003
10.1016/j.immuni.2009.07.010
10.4161/cc.7.13.6234
10.1038/s41587-019-0332-7
10.1089/omi.2011.0118
10.1038/s41422-023-00789-0
10.1016/j.stem.2022.03.007
10.1038/sj.onc.1210755
10.1002/sctm.17-0192
10.1016/j.tig.2020.09.015
10.1038/ncb1353
10.1038/nsmb.1476
10.1038/ng.297
10.4049/jimmunol.181.1.485
10.1084/jem.20100363
10.1084/jem.20151646
10.4049/jimmunol.1701700
10.1016/j.molcel.2013.12.005
10.1038/s41591-018-0290-5
10.1158/2159-8290.CD-20-1661
10.1073/pnas.2218632120
10.1038/s41551-024-01181-y
10.1038/s41551-023-01146-7
10.1038/nmeth.4258
10.1189/jlb.1TA0214-121RR
10.1038/s41467-018-07901-8
10.1186/s13059-015-0846-3
10.1038/nmeth.4396
10.1371/journal.pbio.0050008
10.1038/s41467-018-03214-y
10.1038/s41556-022-00884-1
10.1182/blood-2018-10-882613
|
[
"Jing",
"Falchetti",
"Han",
"Najia",
"Hensch",
"Meader",
"Lummertz da Rocha",
"Kononov",
"Wang",
"Bingham",
"Li",
"Zhao",
"Frenis",
"Kubaczka",
"Yang",
"Jha",
"Rodrigues-Luiz",
"Rowe",
"Schlaeger",
"Maus",
"North",
"Zon",
"Daley"
] |
[
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Graduate Program of Pharmacology, Center for Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil.",
"Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.",
"Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Developmental and Regenerative Biology Program, Harvard Medical School, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.",
"Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: george.daley@childrens.harvard.edu."
] |
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[] | 8.963876 | 3.622638 |
39504625
| 282 |
Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variants.
|
Chimeric antigen receptor (CAR) T cells are a powerful treatment against hematologic cancers. The functional phenotype of a CAR-T cell is influenced by the domains that comprise the synthetic receptor. Typically, the potency of therapeutic CAR-T cell candidates is assessed by preclinical functional assays and mouse models (i.e. human tumor xenografts). However, to date, only a few sets of domains (e.g. CD8, CD28, 41BB) have been extensively tested in preclinical assays and human clinical studies. To characterize the efficiency of a CAR, different assays have been utilized to analyze T cell phenotypes, such as expansion, cytotoxicity, secretome, and persistence. However, each of these previous studies evaluated the importance of an assay differently, resulting in a wide range of functionally diverse CARs. In this review, we highlight recent (high-throughput) methods to analyze CAR domains and demonstrate their impact on inducing T cell phenotypes and activity. We also describe advances in computational methods and their potential for identifying CAR variants with enhanced properties. Finally, we reflect on the need for a standardized scoring system to support the clinical development of next-generation CARs.
|
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] | 2024-11-07 | 1 |
39504625
|
[
"CAR domains",
"T cell phenotypes",
"CAR variants",
"preclinical assays",
"CAR",
"different assays",
"human clinical studies",
"therapeutic CAR-T cell candidates",
"domains",
"computational methods",
"preclinical functional assays and mouse models",
"next-generation CARs",
"enhanced properties",
"functionally diverse CARs",
"hematologic cancers",
"a CAR-T cell",
"expansion",
"CD28",
"41BB",
"cytotoxicity",
"a CAR",
"a standardized scoring system",
"advances",
"i.e. human tumor xenografts",
"The functional phenotype",
"an assay",
"the clinical development",
"persistence",
"date",
"the domains"
] |
[] | 0 |
10.1016/j.copbio.2024.103223
|
[
"Mei",
"Letscher",
"Reddy"
] |
[
"Department of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland; Life Science Zurich Graduate School, ETH Zürich, University of Zurich, 8057 Zürich, Switzerland.",
"Department of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.",
"Department of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland. Electronic address: sai.reddy@ethz.ch."
] |
[
"39504625"
] |
[] | 8.259119 | 4.688591 |
39502704
| 283 |
Mechanisms and salvage treatments in patients with multiple myeloma relapsed post-BCMA CAR-T cell therapy.
|
Chimeric antigen receptor T-cell (CAR-T) therapy has ushered in a new era for the treatment of multiple myeloma (MM). Numerous clinical studies, especially those involving B-cell maturation antigen (BCMA)-directed CAR-T, have shown remarkable efficacy in patients with relapsed or refractory multiple myeloma (R/R MM). However, a considerable number of patients still experience disease recurrence or progression after BCMA CAR-T treatment, which is attributed to various factors, including antigen escape, CAR-T manufacturing factors, T cell exhaustion, inhibitory effects of tumor microenvironment and impact of prior treatments. The scarcity of effective treatment options following post-CAR-T disease recurrence, coupled with the lack of well-established salvage regimens, leaves patients who do relapse facing a bleak prognosis. In recent years, some academic institutions have achieved certain results in salvage treatments of patients with relapse after BCMA CAR-T treatment through secondary infusion of BCMA CAR-T, changing to non-BCMA-directed CAR-T, double-target CAR-T, bispecific antibodies or other novel therapies. This review summarizes the mechanisms of resistance or relapse after BCMA CAR-T administration and the available data on current salvage treatments, hoping to provide ideas for optimizing clinical salvage therapies.
|
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] | 2024-11-06 | 111 |
39502704
|
[
"salvage treatments",
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"relapse",
"other novel therapies",
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"various factors",
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"tumor microenvironment",
"certain results",
"BCMA-directed CAR-T",
"inhibitory effects",
"double-target CAR-T",
"B-cell maturation antigen",
"remarkable efficacy",
"recent years"
] |
[
"BCMA CAR-T",
"T-cell -engaging therapy",
"multiple myeloma",
"relapse",
"salvage treatment"
] | 0 |
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|
[
"Fu",
"Liu",
"Gao",
"Lin",
"He"
] |
[
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.\nNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.\nXi'an Key Laboratory of Hematological Diseases, Xi'an, China."
] |
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[] | 4.950753 | 6.067693 |
39502312
| 284 |
Cellular therapy in older adults with relapsed/refractory diffuse large B-cell lymphoma.
|
Relapsed/Refractory (R/R) diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with poor prognosis and limited therapeutic options. High-dose chemotherapy with autologous hematopoietic stem cell transplantation (autoHCT) was historically the curative-intent treatment for patients who demonstrated chemosensitivity to salvage therapy. However, a significant portion of patients do not make it autoHCT due to disease progression or overall fitness and eligibility. This is of particular concern in the older adult population. In recent years, significant advances in cellular therapies including chimeric antigen receptor (CAR) T-cells and bispecific antibodies, in addition to improvement in autoHCT tolerability, have allowed for additional treatment options for patients with R/R DLBCL. These novel therapies offer the potential for durable remissions and cure, and should be considered in older patients. We present a review focused on the safety and efficacy of cellular therapies in the older adult population with R/R DLBCL.
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] | 2024-11-06 | 45 |
39502312
|
[
"older patients",
"cellular therapies",
"autologous hematopoietic stem cell transplantation",
"salvage therapy",
"additional treatment options",
"patients",
"disease progression",
"limited therapeutic options",
"chimeric antigen receptor",
"significant advances",
"poor prognosis",
"durable remissions",
"bispecific antibodies",
"autoHCT tolerability",
"overall fitness",
"large B-cell lymphoma",
"the older adult population",
"recent years",
"particular concern",
"efficacy",
"improvement",
"addition",
"CAR",
"DLBCL",
"cure",
"T-cells",
"R/R",
"These novel therapies",
"chemosensitivity",
"an aggressive disease"
] |
[
"CAR T",
"CAR T cell",
"DLBCL - diffuse large B cell lymphoma",
"autologous transplant (ASCT)",
"bispecific antibody (bsAb)",
"elderly"
] | 0 |
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10.1016/j.jgo.2015.04.005
10.1016/j.leukres.2019.01.002
10.3109/10428194.2014.1001987
10.1634/theoncologist.2017-0499
10.1111/bjh.13561
10.1038/sj.bmt.1705266
10.1038/sj.bmt.1702833
10.1016/j.bbmt.2008.05.002
10.1002/ajh.23108
10.1038/bmt.2010.289
10.1093/annonc/mdm608
10.1016/j.jtct.2022.12.011
10.1056/NEJMoa2401361
10.1038/s41591-024-02826-w
|
[
"Esteghamat",
"Tsumura",
"Marquez-Arreguin",
"Tuscano"
] |
[
"Division of Malignant Hematology, Cellular Therapy and Transplantation, University of California Davis Comprehensive Cancer Center, Sacramento, CA, United States.",
"Division of Hematology & Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, CA, United States.",
"Schoool of Medicine, University of California, Davis, Sacramento, CA, United States.",
"Division of Malignant Hematology, Cellular Therapy and Transplantation, University of California Davis Comprehensive Cancer Center, Sacramento, CA, United States."
] |
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[] | 6.293687 | 6.039025 |
39501358
| 285 |
Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies.
|
Chimeric antigen receptor (CAR)-T cell therapy demonstrates substantial efficacy in various hematological malignancies. However, its application in solid tumors is still limited. Clinical studies report suboptimal outcomes such as reduced cytotoxicity of CAR-T cells and tumor evasion, underscoring the need to address the challenges of sliding cytotoxicity in CAR-T cells. Despite improvements from fourth and next-generation CAR-T cells, new challenges include systemic toxicity from continuously secreted proteins, low productivity, and elevated costs. Recent research targets genetic modifications to boost killing potential, metabolic interventions to hinder tumor progression, and diverse combination strategies to enhance CAR-T cell therapy. Efforts to reduce the duration and cost of CAR-T cell therapy include developing allogenic and in-vivo approaches, promising significant future advancements. Concurrently, innovative technologies and platforms enhance the potential of CAR-T cell therapy to overcome limitations in treating solid tumors. This review explores strategies to optimize CAR-T cell therapies for solid tumors, focusing on enhancing cytotoxicity and overcoming application restrictions. We summarize recent advances in T cell subset selection, CAR-T structural modifications, infiltration enhancement, genetic and metabolic interventions, production optimization, and the integration of novel technologies, presenting therapeutic approaches that could improve CAR-T cell therapy's efficacy and applicability in solid tumors.
|
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] | 2024-11-06 | 242 |
39501358
|
[
"T cell subset selection",
"CAR)-T cell therapy",
"CAR-T cell therapies",
"CAR-T cell therapy",
"solid tumors",
"tumor progression",
"tumor evasion",
"CAR-T cells",
"reduced cytotoxicity",
"CAR-T cell therapys efficacy",
"genetic modifications",
"sliding cytotoxicity",
"therapeutic approaches",
"diverse combination strategies",
"metabolic interventions",
"substantial efficacy",
"killing potential",
"cytotoxicity",
"novel technologies",
"new challenges",
"suboptimal outcomes",
"CAR-T structural modifications",
"fourth and next-generation CAR-T cells",
"elevated costs",
"significant future advancements",
"innovative technologies",
"production optimization",
"low productivity",
"systemic toxicity",
"infiltration enhancement"
] |
[
"CAR-T cell therapy",
"Challenges of cytotoxicity",
"Novel technologies",
"Restriction in application",
"Solid tumors"
] | 0 |
10.1186/s13045-024-01625-7
|
[
"Ai",
"Liu",
"Chen",
"Huang",
"Yang",
"Zhang",
"Weng",
"Du",
"Wu",
"Lai"
] |
[
"Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.",
"Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510280, Guangdong, China.",
"Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510280, Guangdong, China.",
"Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.",
"Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.",
"Princess Máxima Center for Pediatric Oncology, 3584 CS, Utrecht, The Netherlands.",
"Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510280, Guangdong, China.",
"Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510280, Guangdong, China.",
"Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China. wukm_lab@163.com.\nCancer Center, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. wukm_lab@163.com.",
"Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510280, Guangdong, China. lai_peilong@163.com."
] |
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] |
[] | 9.554832 | 4.470391 |
39500484
| 286 |
Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy.
|
Anti-CD19 Chimeric Antigen Receptor (CAR)-T cell therapies have shown promise for treating B cell malignancies, but the clinical outcome is influenced by both the CAR-T product and the patient's immune system. The role of γδ T cells in the context of CAR-T cell therapy remains poorly understood. This study investigates the transcriptional heterogeneity, clonal expansion and dynamics of γδ T cells in patients undergoing anti-CD19 CAR-T cell therapy. Longitudinal single cell multi-omics analysis was performed on γδ T cells from four patients receiving anti-CD19 CAR-T cell therapy. Single cell RNA-seq, antibody-based protein profiling (AbSeq) and full-length TCRγδ sequences revealed clonally expanded populations displaying plasticity in T cell differentiation, and temporal dynamics of large clones, suggesting ongoing expansion and differentiation. Clonally expanded γδ T cells had heterogeneous gene expression profiles, occupying seven transcriptionally distinct clusters. Analysis of chemokine markers indicated cluster-specific homing tendencies of circulating γδ T cells to peripheral tissues. We found unexpectedly high frequencies of Vδ1 and Vδ3 cells in the blood with distinct gene and protein expression profiles. This analysis provides insights into the dynamic and heterogeneous nature of γδ T cells following anti-CD19 CAR-T cell therapy, contributing valuable information for optimizing CAR-T cell therapies in B cell malignancies.
|
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] | 2024-11-06 | 1 |
39500484
|
[
"Vδ3 cells",
"B cell malignancies",
"Longitudinal single cell multi-omics analysis",
"anti-CD19 CAR-T cell therapy",
"CAR-T cell therapies",
"CAR-T cell therapy",
"γδ T cells",
"T cell differentiation",
"heterogeneous gene expression profiles",
"Anti-CD19 Chimeric Antigen Receptor (CAR)-T cell therapies",
"clonal expansion",
"-seq",
"Clonally expanded γδ T cells",
"temporal dynamics",
"ongoing expansion",
"patients",
"distinct gene and protein expression profiles",
"large clones",
"Analysis",
"dynamics",
"valuable information",
"chemokine markers",
"differentiation",
"antibody-based protein profiling",
"cluster-specific homing tendencies",
"Vδ1",
"peripheral tissues",
"AbSeq",
"TCRγδ",
"plasticity"
] |
[
"CAR‐T cells",
"T cell receptors",
"immune reconstitution",
"immune response dynamics",
"single cell RNA‐seq",
"γδ T cells"
] | 0 |
10.1111/imcb.12834
|
[
"Safavi",
"Samir",
"Singh",
"Bonomi",
"Louie",
"Micklethwaite",
"Luciani"
] |
[
"School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.",
"School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.",
"Garvan Institute of Medical Research, Sydney, NSW, Australia.",
"School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.",
"School of Computer Science and Engineering, UNSW Sydney, Sydney, NSW, Australia.",
"NSW Health Pathology Blood Transplant and Cell Therapies Laboratory - ICPMR Westmead, Sydney, NSW, Australia.\nBlood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.\nWestmead Institute for Medical Research, Sydney, NSW, Australia.\nSydney Medical School, The University of Sydney, Sydney, NSW, Australia.",
"School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.\nGarvan Institute of Medical Research, Sydney, NSW, Australia.\nCellular Genomics Future Institute, UNSW Sydney, Sydney, NSW, Australia."
] |
[
"39500484"
] |
[] | 7.823861 | 4.900138 |
39498846
| 287 |
CAR T-cell therapy for gliomas.
|
To review the landscape of chimeric antigen receptor T-cell (CAR T) therapy for gliomas as seen in recently published trials and discuss on-going challenges with new cancer immunotherapy treatments.
Given how CAR T therapy has revolutionized the treatment of several hematologic malignancies, there has been increasing interest in using immunotherapy, and particularly CAR T therapy for gliomas. Within the past decade, several first in human trials have published early patient experiences showing treatment is generally well tolerated but with limited efficacy, which may be improving with newer evolutions in CAR T design to overcome known resistance mechanisms in glioma treatment.
CAR T therapy is a promising avenue of treatment for high-grade gliomas, which have a universally poor prognosis as well as limited therapeutics. There are a growing number of CAR T clinical trials for CNS tumors and thus, an understanding of their treatment strategies, toxicity management, and overcoming resistance mechanisms will be important for both clinical practice and to identify areas for future research.
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] | 2024-11-05 | 1 |
39498846
|
[
"CAR T therapy",
"CAR T clinical trials",
"glioma treatment",
"CAR T design",
"new cancer immunotherapy treatments",
"treatment",
"known resistance mechanisms",
"human trials",
"resistance mechanisms",
"several hematologic malignancies",
"particularly CAR T therapy",
"gliomas",
"newer evolutions",
"limited efficacy",
"early patient experiences",
"limited therapeutics",
"CNS tumors",
"toxicity management",
"chimeric antigen receptor T-cell (CAR T) therapy",
"immunotherapy",
"future research",
"their treatment strategies",
"high-grade gliomas",
"first",
"areas",
"recently published trials",
"interest",
"CNS",
"the treatment",
"both clinical practice"
] |
[] | 0 |
10.1097/WCO.0000000000001318
|
[
"Song",
"Scott"
] |
[
"Department of Neurology, Stanford University School of Medicine.\nStanford Neuro-Immuno-Oncology (NIO) Program, Stanford, California, USA.",
"Department of Neurology, Stanford University School of Medicine.\nStanford Neuro-Immuno-Oncology (NIO) Program, Stanford, California, USA."
] |
[
"39498846"
] |
[] | 9.889759 | 7.253308 |
39498357
| 288 |
Solid cancer-directed CAR T cell therapy that attacks both tumor and immunosuppressive cells via targeting PD-L1.
|
Chimeric antigen receptor (CAR) T cell therapy has encountered limited success in solid tumors. The lack of dependable antigens and the immunosuppressive tumor microenvironment (TME) are major challenges. Within the TME, tumor cells along with immunosuppressive cells employ an immune-evasion mechanism that upregulates programmed death ligand 1 (PD-L1) to deactivate effector T cells; this makes PD-L1 a reliable, universal target for solid tumors. We developed a novel PD-L1 CAR (MC9999) using our humanized anti-PD-L1 monoclonal antibody, designed to simultaneously target tumor and immunosuppressive cells. The antigen-specific antitumor effects of MC9999 CAR T cells were observed consistently across four solid tumor models: breast cancer, lung cancer, melanoma, and glioblastoma multiforme (GBM). Notably, intravenous administration of MC9999 CAR T cells eradicated intracranially established LN229 GBM tumors, suggesting penetration of the blood-brain barrier. The proof-of-concept data demonstrate the cytolytic effect of MC9999 CAR T cells against immunosuppressive cells, including microglia HMC3 cells and M2 macrophages. Furthermore, MC9999 CAR T cells elicited cytotoxicity against primary tumor-associated macrophages within GBM tumors. The concept of targeting both tumor and immunosuppressive cells with MC9999 was further validated using CAR T cells derived from cancer patients. These findings establish MC9999 as a foundation for the development of effective CAR T cell therapies against solid tumors.
|
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] | 2024-11-05 | 54 |
39498357
|
[
"tumor cells",
"immunosuppressive cells",
"microglia HMC3 cells",
"solid tumors",
"GBM tumors",
"MC9999 CAR T cells",
"effective CAR T cell therapies",
"tumor and immunosuppressive cells",
"MC9999",
"CAR T cells",
"CAR) T cell therapy",
"breast cancer",
"lung cancer",
"effector T cells",
"the immunosuppressive tumor microenvironment",
"intracranially established LN229 GBM tumors",
"LN229 GBM",
"cancer patients",
"Chimeric antigen receptor",
"both tumor and immunosuppressive cells",
"four solid tumor models",
"dependable antigens",
"primary tumor-associated macrophages",
"death ligand",
"GBM",
"a novel PD-L1 CAR",
"M2 macrophages",
"anti-PD-L1",
"glioblastoma multiforme",
"limited success"
] |
[
"CAR T cells",
"MT: Regular Issue",
"PD-L1",
"T cells",
"chimeric antigen receptor",
"immunotherapy",
"solid tumor",
"tumor microenvironment"
] | 0 |
10.1016/j.omton.2024.200891
10.7150/jca.57334
10.3389/fimmu.2019.01337
10.1038/s41571-019-0297-y
10.1016/j.ccell.2020.07.005
10.3324/haematol.2019.229781
10.1007/s10555-021-09997-9
10.1016/j.trecan.2020.10.009
10.1371/journal.pone.0131403
10.3390/cancers13081946
10.7150/jca.14549
10.1007/s00262-020-02520-z
10.1016/j.nucmedbio.2021.05.004
10.1182/blood-2011-02-337360
10.1007/s00262-023-03537-w
10.1080/21645515.2017.1403694
10.1056/NEJMoa1709866
10.1186/s13287-020-02128-1
10.3390/jpm13020221
10.1097/md.0000000000006369
10.3390/ijms21165918
10.3390/cancers12102966
10.1136/jitc-2021-004400
10.3389/fonc.2024.1368732
10.3389/fimmu.2022.973881
10.7554/eLife.36967
10.1038/s41590-022-01215-0
10.1016/j.canlet.2021.12.008
10.1038/s41590-022-01267-2
10.3390/cancers12030683
10.1016/j.isci.2020.101960
10.1038/srep36722
10.1136/jitc-2021-002500
10.1186/s40364-020-00198-0
10.18632/aging.202578
10.3389/fonc.2021.546586
10.1038/s41389-020-00257-z
10.1002/cti2.1154
10.1186/s40425-019-0770-2
10.1016/j.cell.2016.01.011
10.1126/scitranslmed.abe7378
10.1111/j.1537-2995.2006.01033.x
10.1016/j.jneumeth.2009.02.014
10.1371/journal.pone.0150271
10.1038/onc.2015.452
10.1158/0008-5472.Can-13-2103
10.1073/pnas.1016912108
10.1038/onc.2011.58
10.1158/1535-7163.Mct-20-0547
10.1038/s41598-017-08121-8
10.1016/S0022-1759(03)00265-5
10.1126/scitranslmed.aaw9414
|
[
"Luo",
"Gadd",
"Qie",
"Otamendi-Lopez",
"Sanchez-Garavito",
"Brooks",
"Ulloa Navas",
"Hundal",
"Li",
"Jones",
"Lou",
"Patel",
"Dronca",
"Kharfan-Dabaja",
"Dong",
"Quinones-Hinojosa",
"Qin"
] |
[
"Regenerative Immunotherapy and CAR-T Translational Research Program, Mayo Clinic, Jacksonville, FL, USA.\nDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.",
"Regenerative Immunotherapy and CAR-T Translational Research Program, Mayo Clinic, Jacksonville, FL, USA.",
"Regenerative Immunotherapy and CAR-T Translational Research Program, Mayo Clinic, Jacksonville, FL, USA.",
"The Neurosurgery Department, Mayo Clinic, Jacksonville, FL, USA.",
"The Neurosurgery Department, Mayo Clinic, Jacksonville, FL, USA.",
"The Neurosurgery Department, Mayo Clinic, Jacksonville, FL, USA.",
"The Neurosurgery Department, Mayo Clinic, Jacksonville, FL, USA.",
"Regenerative Immunotherapy and CAR-T Translational Research Program, Mayo Clinic, Jacksonville, FL, USA.",
"Regenerative Immunotherapy and CAR-T Translational Research Program, Mayo Clinic, Jacksonville, FL, USA.",
"The Neurosurgery Department, Mayo Clinic, Jacksonville, FL, USA.",
"Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.\nDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.",
"Hepatology & Liver Transplantation, Mayo Clinic, Jacksonville, FL, USA.\nDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.",
"Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.",
"Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.\nBlood and Marrow Transplantation and Cellular Therapy Program, Mayo Clinic, Jacksonville, FL, USA.",
"Department of Urology, Mayo Clinic, Rochester, MN, USA.\nDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.",
"The Neurosurgery Department, Mayo Clinic, Jacksonville, FL, USA.\nDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.",
"Regenerative Immunotherapy and CAR-T Translational Research Program, Mayo Clinic, Jacksonville, FL, USA.\nDivision of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.\nDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.\nDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA."
] |
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[] | 9.752422 | 5.634457 |
39497428
| 289 |
Engineering and targeting potential of CAR NK cells in colorectal cancer.
|
Colorectal cancer (CRC), a major global health concern, necessitates innovative treatments. Chimeric antigen receptor (CAR) T cells have shown promise, yet they grapple with challenges. The spotlight pivots to the rising heroes: CAR natural killer (NK) cells, offering advantages such as higher safety profiles, cost-effectiveness, and efficacy against solid tumors. Nevertheless, the specific mechanisms underlying CAR NK cell trafficking and their interplay within the complex tumor microenvironment require further in-depth exploration. Herein, we provide insights into the design and engineering of CAR NK cells, antigen targets in CRC, and success in overcoming resistance mechanisms with an emphasis on the potential for clinical trials.
|
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] | 2024-11-05 | 1 |
39497428
|
[
"CAR NK cells",
"CAR NK cell trafficking",
"CAR NK",
"resistance mechanisms",
"higher safety profiles",
"antigen targets",
"solid tumors",
"CRC",
"innovative treatments",
"clinical trials",
"Colorectal cancer",
"a major global health concern",
"engineering",
"CAR",
"success",
"advantages",
"the complex tumor microenvironment",
"promise",
"efficacy",
"insights",
"challenges",
"the specific mechanisms",
"cost-effectiveness",
"the rising heroes",
"an emphasis",
"their interplay",
"the potential",
"the design",
"-depth",
"they"
] |
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|
[
"Khawar",
"Afzal",
"Dong",
"Si",
"Sun"
] |
[
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China.\nJiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research, Yangzhou, Jiangsu 225009, China.\nApplied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Punjab 51600, Pakistan.",
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China.\nMolecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences and Technology, University of Central Punjab, Lahore, Punjab 54000, Pakistan.",
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China.\nDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, China.",
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China.\nJiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research, Yangzhou, Jiangsu 225009, China.",
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China.\nJiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research, Yangzhou, Jiangsu 225009, China."
] |
[
"39497428"
] |
[] | 11.00773 | 5.440389 |
39495525
| 290 |
CAR T Cells and T-Cell Therapies for Cancer: A Translational Science Review.
|
Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell. CAR T treatments improve overall survival for patients with large B-cell lymphoma and progression-free survival for patients with multiple myeloma.
Six CAR T-cell products are approved by the US Food and Drug Administration (FDA) for 6 hematologic malignancies: B-cell acute lymphoblastic leukemia, large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, and multiple myeloma. Compared with standard chemotherapy followed by stem cell transplant, CAR T cells improved 4-year overall survival in patients with large B-cell lymphoma (54.6% vs 46.0%). Patients with pediatric acute lymphoblastic leukemia achieved durable remission after CAR T-cell therapy. At 3-year follow-up, 48% of patients were alive and relapse free. In people with multiple myeloma treated previously with 1 to 4 types of non-CAR T-cell therapy, CAR T-cell therapy prolonged treatment-free remissions compared with standard treatments (in 1 trial, CAR T-cell therapy was associated with progression-free survival of 13.3 months compared with 4.4 months with standard therapy). CAR T-cell therapy is associated with reversible acute toxicities, such as cytokine release syndrome in approximately 40% to 95% of patients, and neurologic disorders in approximately 15% to 65%. New CAR T-cell therapies in development aim to increase efficacy, decrease adverse effects, and treat other types of cancer. No CAR T-cell therapies are FDA approved for solid tumors, but recently, 2 other T lymphocyte-based treatments gained approvals: 1 for melanoma and 1 for synovial cell sarcoma. Additional cellular therapies have attained responses for certain solid tumors, including pediatric neuroblastoma, synovial cell sarcoma, melanoma, and human papillomavirus-associated cancers. A common adverse effect occurring with these T lymphocyte-based therapies is capillary leak syndrome, which is characterized by fluid retention, pulmonary edema, and kidney dysfunction.
CAR T-cell therapy is an FDA-approved therapy that has improved progression-free survival for multiple myeloma, improved overall survival for large B-cell lymphoma, and attained high rates of cancer remission for other hematologic malignancies such as acute lymphoblastic leukemia, follicular lymphoma, and mantle cell lymphoma. Recently approved T lymphocyte-based therapies demonstrated the potential for improved outcomes in solid tumor malignancies.
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] | 2024-11-04 | 1 |
39495525
|
[
"CAR T cells",
"mantle cell lymphoma",
"synovial cell sarcoma",
"stem cell transplant",
"standard therapy",
"T lymphocytes",
"CAR T-cell therapy",
"New CAR T-cell therapies",
"non-CAR T-cell therapy",
"CAR T treatments",
"solid tumor malignancies",
"large B-cell lymphoma",
"Additional cellular therapies",
"B-cell acute lymphoblastic leukemia",
"CAR T-cell therapy prolonged treatment-free remissions",
"overall survival",
"solid tumors",
"certain solid tumors",
"pediatric acute lymphoblastic leukemia",
"acute lymphoblastic leukemia",
"a tumor cell surface antigen",
"follicular lymphoma",
"standard treatments",
"other hematologic malignancies",
"the T cell",
"multiple myeloma",
"No CAR T-cell therapies",
"the tumor cell",
"improved outcomes",
"chronic lymphocytic leukemia"
] |
[] | 0 |
10.1001/jama.2024.19462
|
[
"Brudno",
"Maus",
"Hinrichs"
] |
[
"Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.",
"Department of Medicine, Massachusetts General Hospital Cancer Center, Boston.",
"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute of New Jersey, New Brunswick."
] |
[
"39495525"
] |
[] | 7.095613 | 4.737494 |
39492698
| 291 |
Current and future strategies for the prevention and treatment of cytomegalovirus infections in transplantation.
|
Successful prevention and treatment of cytomegalovirus (CMV) infection remains a central focus of clinical care in solid organ and allogeneic hematopoietic cell transplantation. Over the past 5 years, pivotal clinical trials have created new paradigms in CMV prevention, including diverging approaches in HCT and SOT. We review recent advances in CMV risk assessment and progress in antiviral and immune-based strategies for CMV prevention and treatment. We highlight approaches to optimize CMV-specific immunity through vaccination, monoclonal antibodies, and virus-specific T-cells. Observational studies and interventional trials of commercially-available CMV cell-mediated immunity assays for refining preventive and treatment strategies are summarized. Finally, we discuss the importance of enhancing CMV-specific immunity to mitigate the negative impacts of CMV in different transplant settings. CMV infections in recipients of chimeric antigen receptor-T (CAR-T) cell therapies and other immunocompromised populations are growing areas of importance that are beyond the scope of this review.
|
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0.008778032846748829
] | 2024-11-04 | 1 |
39492698
|
[
"CMV prevention",
"CMV risk assessment",
"CMV",
"pivotal clinical trials",
"allogeneic hematopoietic cell transplantation",
"CMV infections",
"clinical care",
"interventional trials",
"other immunocompromised populations",
"Successful prevention",
"CMV-specific immunity",
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"new paradigms",
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"progress",
"vaccination",
"recipients",
"HCT",
"antiviral and immune-based strategies",
"SOT"
] |
[] | 0 |
10.1093/cid/ciae535
|
[
"Heldman",
"Boeckh",
"Limaye"
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[
"Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.",
"Division of Allergy and Infectious Diseases Division, Department of Medicine, University of Washington, Seattle, WA, USA.\nVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.\nClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.",
"Division of Allergy and Infectious Diseases Division, Department of Medicine, University of Washington, Seattle, WA, USA."
] |
[
"39492698"
] |
[] | 8.600052 | 4.02514 |
39492678
| 292 |
Editor's Note: Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor.
| null |
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] | 2024-11-04 | 1 |
39492678
|
[] |
[] | 0 |
10.1158/0008-5472.CAN-24-2930
|
[
"Zhao",
"Moon",
"Carpenito",
"Paulos",
"Liu",
"Brennan",
"Chew",
"Carroll",
"Scholler",
"Levine",
"Albelda",
"June"
] |
[
null,
null,
null,
null,
null,
null,
null,
null,
null,
null,
null,
null
] |
[
"39492678"
] |
[] | 32.986763 | 7.525641 |
39490997
| 293 |
Focusing on exosomes to overcome the existing bottlenecks of CAR-T cell therapy.
|
Since chimeric antigen receptor T (CAR-T) cells were introduced three decades ago, the treatment using these cells has led to outstanding outcomes, and at the moment, CAR-T cell therapy is a well-established mainstay for treating CD19 + malignancies and multiple myeloma. Despite the astonishing results of CAR-T cell therapy in B-cell-derived malignancies, several bottlenecks must be overcome to promote its safety and efficacy and broaden its applicability. These bottlenecks include cumbersome production process, safety concerns of viral vectors, poor efficacy in treating solid tumors, life-threatening side effects, and dysfunctionality of infused CAR-T cells over time. Exosomes are nano-sized vesicles that are secreted by all living cells and play an essential role in cellular crosstalk by bridging between cells. In this review, we discuss how the existing bottlenecks of CAR-T cell therapy can be overcome by focusing on exosomes. First, we delve into the effect of tumor-derived exosomes on the CAR-T cell function and discuss how inhibiting their secretion can enhance the efficacy of CAR-T cell therapy. Afterward, the application of exosomes to the manufacturing of CAR-T cells in a non-viral approach is discussed. We also review the latest advancements in ex vivo activation and cultivation of CAR-T cells using exosomes, as well as the potential of engineered exosomes to in vivo induction or boost the in vivo proliferation of CAR-T cells. Finally, we discuss how CAR-engineered exosomes can be used as a versatile tool for the direct killing of tumor cells or delivering intended therapeutic payloads in a targeted manner.
|
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] | 2024-11-04 | 141 |
39490997
|
[
"tumor cells",
"cells",
"CAR-T cell therapy",
"infused CAR-T cells",
"CAR-T cells",
"engineered exosomes",
"Exosomes",
"exosomes",
"the CAR-T cell function",
"solid tumors",
"poor efficacy",
"nano-sized vesicles",
"several bottlenecks",
"safety concerns",
"ex vivo activation",
"intended therapeutic payloads",
"all living cells",
"efficacy",
"viral vectors",
"cumbersome production process",
"chimeric antigen receptor T (CAR-T) cells",
"tumor-derived exosomes",
"B-cell-derived malignancies",
"these cells",
"CAR-engineered exosomes",
"vivo induction",
"cellular crosstalk",
"outstanding outcomes",
"multiple myeloma",
"a non-viral approach"
] |
[
"Anti-tumor agents",
"CAR-T cell",
"Cancer immunotherapy",
"Exosomes",
"Extracellular vesicles",
"Targeted therapies"
] | 0 |
10.1186/s41232-024-00358-x
|
[
"Zhang",
"Peng",
"Chen",
"Xu",
"Moradi"
] |
[
"Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, 999078, China.\nZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, 310000, China.",
"Wuhu Hospital, East China Normal University (The Second People's Hospital of Wuhu), Wuhu, 241000, China.",
"Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, 999078, China.",
"Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, 310000, China. xuyan_zjcdc@163.com.",
"Hematology and Bood Transfusion Science Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. moradi_v@alumnus.tums.ac.ir."
] |
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] |
[] | 9.458493 | 3.545245 |
39490640
| 294 |
Applying metabolic control strategies to engineered T cell cancer therapies.
|
Chimeric antigen receptor (CAR) T cells are an engineered immunotherapy that express synthetic receptors to recognize and kill cancer cells. Despite their success in treating hematologic cancers, CAR T cells have limited efficacy against solid tumors, in part due to the altered immunometabolic profile within the tumor environment, which hinders T cell proliferation, infiltration, and anti-tumor activity. For instance, CAR T cells must compete for essential nutrients within tumors, while resisting the impacts of immunosuppressive metabolic byproducts. In this review, we will describe the altered metabolic features within solid tumors that contribute to immunosuppression of CAR T cells. We'll discuss how overexpression of key metabolic enzymes can enhance the ability of CAR T cells to resist corresponding tumoral metabolic changes or even revert the metabolic profile of a tumor to a less inhibitory state. In addition, metabolic remodeling is intrinsically linked to T cell activity, differentiation, and function, such that metabolic engineering strategies can also promote establishment of more or less efficacious CAR T cell phenotypes. Overall, we will show how applying metabolic engineering strategies holds significant promise in improving CAR T cells for the treatment of solid tumors.
|
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39490640
|
[
"CAR T cells",
"T cell activity",
"T cell proliferation",
"cancer cells",
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"metabolic remodeling",
"key metabolic enzymes",
"solid tumors",
"corresponding tumoral metabolic changes",
"immunosuppressive metabolic byproducts",
"tumors",
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"hematologic cancers",
"the metabolic profile",
"the altered metabolic",
"significant promise",
"essential nutrients",
"limited efficacy",
"the tumor environment",
"CAR",
"infiltration",
"part",
"function",
"establishment",
"differentiation",
"the altered immunometabolic profile",
"immunosuppression",
"a tumor"
] |
[
"CAR T cell therapies",
"Cellular engineering",
"Immunotherapy",
"Metabolic engineering",
"Tumor microenvironment"
] | 0 |
10.1016/j.ymben.2024.10.009
10.1056/NEJMoa1003466
10.1056/NEJMoa1910836
10.1200/JCO.2017.35.15_suppl.9011
10.1200/EDBK_201319
10.1038/leu.2015.104
10.1200/EDBK_240837
10.1080/08820139.2022.2096463
10.1158/2159-8290.CD-13-0985
10.1038/s41392-023-01332-8
10.1186/s13045-022-01282-8
10.1016/B978-0-12-822620-9.00021-5
10.1007/978-3-030-65768-0_1
10.4251/wjgo.v14.i6.1124
10.1002/eji.200838289
10.1158/0008-5472.CAN-15-3121
10.1016/j.cell.2015.08.012
10.1042/bj2490443
10.1038/nrc.2017.86
10.1038/s41598-019-48635-x
10.1038/s41586-021-04390-6
10.1158/1078-0432.CCR-18-2035
10.1002/hon.124_2629
10.1007/s12015-019-09901-7
10.3389/fonc.2022.979154
10.1084/jem.20151159
10.1371/journal.pone.0104104
10.1016/j.immuni.2018.01.007
10.3389/fimmu.2021.725618
10.1038/s41586-024-07300-8
10.1186/s40164-020-00190-2
10.1182/bloodadvances.2022008272
10.1038/s41467-023-38316-9
10.1038/s41586-019-1126-2
10.1016/j.molcel.2020.09.006
10.1186/s13046-023-02845-4
10.3389/fimmu.2017.00864
10.2217/imt-2016-0118
10.1007/s00005-021-00633-6
10.1016/j.cell.2016.09.031
10.1016/j.celrep.2024.113995.
10.1016/j.immuni.2005.03.013
10.1038/s41420-021-00579-w
10.4049/jimmunol.0903586
10.1038/s41423-021-00833-2
10.1016/j.ajps.2019.12.002
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10.1111/cas.14862
10.1182/blood.2019004500
10.1042/BST20190331
10.1136/jitc-2021-002840
10.1038/s41419-023-06376-w
10.1038/s41586-021-03442-1
10.1002/JLB.1MR0421-597RR
10.1172/JCI69589
10.1016/j.jcyt.2019.03.348
10.4049/jimmunol.1800230
10.1016/j.ymthe.2021.08.003
10.1186/s40170-018-0184-5
10.1371/journal.pone.0191533
10.1016/j.ymthe.2024.05.006
10.1007/s00424-020-02416-y
10.1038/s41556-017-0002-2
10.3109/08830185.2015.1082178
10.1038/s41589-022-01017-3
10.1084/jem.20191920
10.1074/jbc.M112.386045
10.1038/emboj.2009.6
10.1111/j.1600-065X.2012.01150.x
10.1038/nature17412
10.1016/j.omto.2020.01.008
10.1016/j.cmet.2021.02.015
10.1016/j.immuni.2021.05.003
10.1042/bst0311095
10.1186/s13045-022-01255-x
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10.1158/2326-6066.CIR-22-0565
10.1016/j.cmet.2023.12.010
10.1371/journal.pone.0266980
10.1038/s41423-020-0365-3
10.1136/jitc-2022-006522
10.1038/s41586-022-05126-w
10.1038/s41586-019-1821-z
10.1038/s41467-022-35583-w
10.1038/s41467-024-48653-y
10.1073/pnas.1920413117
10.3390/ijms23115970
10.1136/jitc-2021-003013
10.1182/blood-2015-01-621474
10.1080/2162402X.2022.2055703
10.1136/jitc-2020-ITOC7.84
10.1089/hum.2021.050
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10.1016/j.yexcr.2021.112886
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10.1016/j.molmed.2015.11.003
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10.1016/j.jbo.2022.100430
10.4049/jimmunol.1401710
10.1089/ars.2011.4073
10.1016/j.ymthe.2024.03.033
10.1038/s12276-020-0375-3
10.1016/j.celrep.2019.08.034
10.3389/fcell.2018.00096
10.1371/journal.pone.0068245.
10.1038/s42003-021-01664-7
10.1002/biot.202300446
10.1038/s41551-021-00781-2
10.1016/j.omto.2018.11.003
10.1016/j.cell.2020.07.038
10.1016/j.cmet.2023.02.013
10.21203/rs.3.rs-4020589/v1
10.1158/1538-7445.AM2024-3610
10.1158/1535-7163.MCT-20-0430
10.1002/ijc.32028
10.1038/s41556-022-00985-x
10.1080/14756366.2023.2290911
10.1016/j.molcel.2020.10.015
10.1038/s41586-024-07242-1
10.21203/rs.3.rs-2584153/v1
10.1038/s41587-023-02060-8
10.1038/s41576-021-00329-9
10.1007/s13402-024-00954-6
10.1074/jbc.RA117.000631
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|
[
"Fox",
"Blazeck"
] |
[
"School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta GA 303332, USA.",
"School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta GA 303332, USA. Electronic address: john.blazeck@chbe.gatech.edu."
] |
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[] | 10.069921 | 4.990209 |
39489212
| 295 |
Engraftment of a surrogate antigen onto tumor cell surface via pHLIP peptide to universally target CAR-T cell therapy to solid tumors.
|
CAR-T cells and monoclonal antibodies (mAbs) are immunotherapeutics that have shown efficacies against certain malignancies. However, their broad application is hindered by the scarcity of tumor-associated antigens on tumor cell surfaces. Previous investigations unveiled the unique capacity of pH-low insertion peptide (pHLIP) to anchor to plasma membranes under acidic conditions. Considering that an acidic tumor microenvironment is a hallmark of solid tumors, we engineered a novel peptide, Myc-pHLIP, by tethering a surrogate epitope tag, the c-Myc-tag, to pHLIP. We evaluated the efficiency of Myc-pHLIP in inserting the artificial c-Myc-tag onto the plasma membrane of malignant cells and determined if this engraftment could convert it into a therapeutic target for CAR-T cells or mAbs. Our in vitro experiments demonstrated that incubating Myc-pHLIP with tumor cells in acidic media triggered significant killing by either Myc-targeted CAR-T cells (Myc-CAR-T), or by an anti-Myc mAb in the presence of NK cells. In vivo studies demonstrated substantial antitumor effects with sequential administration of Myc-pHLIP followed by either Myc-CAR-T or Myc-mAb. These findings establish that Myc-pHLIP has the potential to act as a universal surrogate tumor antigen capable of directing CAR-T cells or mAbs to treat any solid tumors by concurrently targeting both malignant and stromal cells.
|
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] | 2024-11-04 | 1 |
39489212
|
[
"tumor cells",
"tumor cell surfaces",
"malignant cells",
"NK cells",
"solid tumors",
"pHLIP",
"acidic media",
"CAR-T cells",
"substantial antitumor effects",
"Myc-pHLIP",
"plasma membranes",
"a universal surrogate tumor antigen",
"acidic conditions",
"mAbs",
"an acidic tumor microenvironment",
"sequential administration",
"tumor-associated antigens",
"either Myc-targeted CAR-T cells",
"monoclonal antibodies",
"significant killing",
"Previous investigations",
"any solid tumors",
"certain malignancies",
"Myc-mAb",
"vivo studies",
"pH-low insertion peptide",
"a surrogate epitope tag",
"Myc-CAR-T",
"immunotherapeutics",
"both malignant and stromal cells"
] |
[
"Antibody therapy",
"CAR-T cells",
"Cancer immunotherapy",
"Surrogate tumor antigen",
"Targeting acidic tumor microenvironment",
"pHLIP peptide"
] | 0 |
10.1016/j.canlet.2024.217319
|
[
"Zhang",
"Fu",
"Ting Lim",
"Zhang"
] |
[
"Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA; Coriell Institute for Medical Research, 403 Haddon Ave, Camden, NJ, 08103, USA; Department Biomedical Sciences, Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ, 08103, USA.",
"Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA.",
"Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA.",
"Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA. Electronic address: shaunzhang@uh.edu."
] |
[
"39489212"
] |
[] | 9.790109 | 5.410284 |
39487875
| 296 |
Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells.
|
The use of chimeric antigen receptor (CAR)-T cells has enhanced the range of available therapeutic modalities in the context of cancer treatment. CAR-T cells have demonstrated considerable efficacy in the targeted eradication of blood cancer cells, thereby stimulating substantial interest in the advancement of such therapeutic approaches. However, the efficacy of CAR-T cells against solid tumor cells has been limited due to the presence of various obstacles. Solid tumors exhibit antigenic diversity and an immunosuppressive microenvironment, which presents a challenge for immune cells attempting to penetrate the tumor. CAR-T cells also demonstrate decreased proliferative activity and cytotoxicity. Furthermore, concerns exist regarding tumor antigen loss and therapy-associated toxicity. Currently, scientists are working to enhance the structure of the CAR and improve the survival and efficiency of CAR-T cells in recognizing tumor antigens in solid tumors. Chemotherapy drugs are frequently employed in the treatment of malignant neoplasms and can also be used prior to cell therapy to enhance CAR-T cell engraftment. Recent studies have demonstrated that chemotherapy drugs can mitigate the suppressive impact of TME, eliminate the physical barrier by destroying the tumor stroma, and facilitate greater penetration of immune cells and CAR-T cells into the tumor. This, in turn, increases their survival, persistence, and cytotoxicity, as well as affects the metabolism of immune cells inside the tumor. However, the effectiveness of the combined approach against solid tumors depends on several factors, including the type of tumor, dosage, population of CAR-T cells, and individual characteristics of the body. This review examines the principal obstacles to the utilization of CAR-T cells against solid tumors, proposes solutions to these issues, and assesses the potential advantages of a combined approach to radiation exposure, which has the potential to enhance the sensitivity of the tumor to other agents.
|
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] | 2024-11-04 | 108 |
39487875
|
[
"solid tumor cells",
"immune cells",
"Solid tumors",
"solid tumors",
"cell therapy",
"tumor antigens",
"CAR)-T cells",
"blood cancer cells",
"tumor antigen loss",
"tumor",
"CAR-T cell engraftment",
"CAR-T cells",
"such therapeutic approaches",
"chimeric antigen receptor",
"Chemotherapy drugs",
"chemotherapy drugs",
"cancer treatment",
"available therapeutic modalities",
"CAR",
"the tumor stroma",
"various obstacles",
"decreased proliferative activity",
"considerable efficacy",
"substantial interest",
"antigenic diversity",
"radiation exposure",
"malignant neoplasms",
"greater penetration",
"several factors",
"the tumor"
] |
[
"CAR-T cell therapy",
"Chemotherapy",
"Chimeric antigen receptor",
"Radiation therapy",
"Solid tumor"
] | 0 |
10.1007/s00262-024-03817-z
|
[
"Khaliulin",
"Valiullina",
"Petukhov",
"Yuan",
"Spada",
"Bulatov"
] |
[
"Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia, 420008.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia, 420008.",
"Nazarbaev University, Qabanbay Batyr Ave 53, 010000, Astana, Kazakhstan.",
"School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, People's Republic of China.",
"Tumor Immunology and Immunotherapy Unit, IRCCS-Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144, Rome, Italy.",
"Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia, 420008. chembio.kazan@gmail.com.\nShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, 117997. chembio.kazan@gmail.com.\nFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia, 119048. chembio.kazan@gmail.com."
] |
[
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[] | 9.736588 | 4.853519 |
39488837
| 297 |
Protocol for live-cell imaging of immune synapse formation and activation of CAR T cells against cancer cells.
|
Immune synapse (IS) formation determines T cell antitumor activity. Here, we present a protocol for characterizing the IS formation between chimeric antigen receptor (CAR) T cells and tumor cells by measuring the IS size and calcium flux by live-cell imaging. We describe steps for CAR T cell manufacturing, sample preparation, image acquisition, and data analysis. For complete details on the use and execution of this protocol, please refer to Chockley et al.,
|
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] | 2024-11-03 | 13 |
39488837
|
[
"tumor cells",
"IS",
"chimeric antigen receptor",
"CAR T cell manufacturing",
"image acquisition",
"sample preparation",
"T cell antitumor activity",
"CAR",
"complete details",
"data analysis",
"live-cell imaging",
"Chockley",
"execution",
"the IS formation",
"et",
"calcium",
"size",
"CAR) T cells",
"al",
"steps",
"a protocol",
"this protocol",
"the use",
"We",
"we"
] |
[
"cancer",
"immunology",
"microscopy"
] | 0 |
10.1016/j.xpro.2024.103422
10.4049/jimmunol.1600458
10.1016/j.xcrm.2023.101297
10.1016/j.xcrm.2024.101422
10.1038/s41467-021-24168-8
10.1038/s41467-022-28243-6
10.1038/nmeth.2019
10.1038/s41592-022-01507-1
10.1038/mt.2016.116
10.1007/s00401-019-01975-4
10.3389/fcell.2021.673446
10.1002/bies.201700003
|
[
"Ibanez",
"Hebbar",
"Thanekar",
"Yi",
"Houke",
"Ward",
"Nevitt",
"Tian",
"Mack",
"Sheppard",
"Chiang",
"Velasquez",
"Krenciute"
] |
[
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address: paulina.velasquez@stjude.org.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address: giedre.krenciute@stjude.org."
] |
[
"39488837",
"27431984",
"37992682",
"38350450",
"34215733",
"35102167",
"22743772",
"35654950",
"27401038",
"30770999",
"37759484",
"34368126",
"28749075"
] |
[] | 8.565584 | 4.878312 |
39488831
| 298 |
Protocol to measure human IL-6 secretion from CAR T cell-primed macrophage and monocyte lineage cells in vitro and in vivo using humanized mice.
|
Chimeric antigen receptor (CAR) T cell therapy often causes serious toxicities, such as cytokine release syndrome (CRS), mainly due to interleukin-6 (IL-6) secreted by monocyte lineage cells. Here, we describe a protocol to generate anti-CD19 CAR T cells and quantify human monocyte-derived IL-6 cocultured with CAR T cells and target tumor cells in vitro. We further describe a protocol to generate a humanized mouse model and evaluate CAR T cell-associated plasma IL-6 levels in vivo. For complete details on the use and execution of this protocol, please refer to Yoshikawa et al.
|
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] | 2024-11-03 | 10 |
39488831
|
[
"monocyte lineage cells",
"tumor cells",
"cytokine release syndrome",
"anti-CD19 CAR T cells",
"CAR T cells",
"CAR T cell-associated plasma IL-6 levels",
"serious toxicities",
"Chimeric antigen receptor",
"CAR) T cell therapy",
"complete details",
"execution",
"human monocyte-derived IL-6",
"IL-6",
"interleukin-6",
"CRS",
"Yoshikawa",
"monocyte",
"et",
"a humanized mouse model",
"al",
"vivo",
"a protocol",
"this protocol",
"the use",
"We",
"we"
] |
[
"Cancer",
"Cell culture",
"Flow Cytometry",
"Immunology"
] | 0 |
10.1016/j.xpro.2024.103423
10.1016/j.xcrm.2024.101526
10.1038/s41591-018-0036-4
10.1084/jem.20221988
10.1038/s41591-018-0041-7
10.1182/blood.2021012714
10.1016/s0161-5890(97)00144-2
10.1158/2643-3230.Bcd-21-0181
10.1182/blood-2018-10-881722
10.1093/intimm/dxae015
|
[
"Nguyen",
"Yoshikawa",
"Ito",
"Kasuya",
"Nakashima",
"Okamoto",
"Amaishi",
"Zhang",
"Li",
"Matsukawa",
"Inoue",
"Kagoya"
] |
[
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan; Department of Hematology and Oncology, Nagoya City University Institute of Medical and Pharmaceutical Sciences, Nagoya 467-8601, Japan.",
"Takara Bio Inc., Shiga 525-0058, Japan.",
"Takara Bio Inc., Shiga 525-0058, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan; Division of Cellular Oncology, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan; Division of Cellular Oncology, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan; Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.",
"Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan; Division of Immune Response, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. Electronic address: ykagoya@keio.jp."
] |
[
"39488831",
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"34861037",
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] |
[] | 6.511696 | 4.268524 |
39487603
| 299 |
Glycolytic activity following anti-CD19 CAR-T cell infusion in non-Hodgkin lymphoma.
|
Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lactate in the first weeks post-CAR-T infusion. In 17 patients treated with CD28 harbording anti-CD19 CAR-T for relapsed/refractory non-Hodgkin lymphomas, PB lactate levels increased following CAR-T infusion. Elevated lactate levels correlated with longer CAR-T persistence and higher CD8+/CD4+ ratio. Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring.
|
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] | 2024-11-02 | 16 |
39487603
|
[
"PB lactate levels",
"CD28 harbording anti-CD19 CAR",
"Peripheral blood lactate kinetics",
"Elevated lactate levels",
"immune cells activation",
"lactate kinetics",
"non-Hodgkin",
"anti-CD19 CAR-T",
"chimeric antigen receptor-T cells",
"longer CAR-T persistence",
"higher CD8+/CD4",
"relapsed/refractory non-Hodgkin lymphomas",
"PB",
"CAR-T infusion",
"the first weeks post-CAR-T infusion",
"Energy metabolism",
"+ ratio",
"bedside monitoring",
"peripheral blood (PB) lactate",
"CD28",
"humans",
"CAR-T) activation",
"the first weeks",
"a glycolytic activity",
"the dynamics",
"17 patients",
"17",
"we"
] |
[
"CAR‐T cells",
"NHL",
"T cells",
"cell therapy",
"metabolism"
] | 0 |
10.1111/eci.14342
|
[
"Vallet",
"Drieu Larochelle",
"Santiago-Ribeiro",
"Villate",
"Eloit",
"Cirée",
"Zaragoza",
"André",
"Prat-Lepesant",
"Hérault",
"Arbion",
"Blasco",
"Gyan"
] |
[
"Hematology and Cell Therapy, University Hospital Tours, Tours, France.\nInserm U1069 N2COx, University of Tours, Tours, France.",
"Hematology and Cell Therapy, University Hospital Tours, Tours, France.",
"Department Imaging Nuclear Medicine, University Hospital Tours, Tours, France.",
"Hematology and Cell Therapy, University Hospital Tours, Tours, France.",
"Hematology and Cell Therapy, University Hospital Tours, Tours, France.",
"Department of Biological Immunology, University Hospital Tours, Tours, France.",
"Department of Pharmacy, University Hospital Tours, Tours, France.",
"Department of Pharmacy, University Hospital Tours, Tours, France.",
"Etablissement Français du Sang, Tours, France.",
"Inserm U1069 N2COx, University of Tours, Tours, France.\nDepartment of Biological Hematology, University Hospital Tours, Tours, France.",
"Department of Pathology, University Hospital Tours, Tours, France.",
"Department of Biochemistry, University Hospital Tours, Tours, France.",
"Hematology and Cell Therapy, University Hospital Tours, Tours, France.\nInserm U1069 N2COx, University of Tours, Tours, France."
] |
[
"39487603",
"29567707",
"35015685",
"31953257",
"26885860",
"27991883",
"19460998",
"37796407",
"26903338",
"37595589",
"25090630",
"35902861",
"29808007",
"23733335",
"33674584",
"27745970"
] |
[] | 6.015209 | 5.293672 |
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