input: [Clip #] 3 [Running Time] 1 minute 58 seconds [MPG File*] sp_green_03.mpg (285 MB) [MP4 File**] sp_green_03.mp4 (11.7 MB) [Quotes (Text)] 
output: And so we describe these five domains, some of which that have been very active this past decade, but others are more far reaching, but nonetheless, we want to think about research agendas that will really inform us and make us more sophisticated in those domains. It starts at the most proximal end of that progression by simply understanding the structure of genomes, sounds like what we did in the Human Genome Project and certainly included activities that have been going on since the Human Genome Project. But then it's about understanding how the human genome works and advancing our knowledge of genome function and that was very importantly and certainly was a major emphasis of our strategic vision starting right when the genome project was completed. The third domain starts to apply that knowledge of genomics to advance our understanding of human disease. And here is the progression that in many ways the fields of genomics is most aggressively pursuing really using the tools and technology of genomics to better understand molecular basis of disease. The fourth domain then moves you from having that knowledge of disease to actually changing medical science by advancing how you approach medical science. There you start to see clinical applications but you can't stop there, and this was one of the key things we heard from our colleagues in genomics community and members of the biomedical research community who has had experience in taking discoveries all the way to the bedside. Now there is even a fifth domain that one needs to contemplate and that's actually demonstrating effectiveness of these advances to the actual delivery of healthcare. Just because you have a medical advance doesn't mean that it's actually going to prove to be effective when actually executed in the healthcare delivery study. You need to actually have a research agenda that studies that last area if you're ultimately going to have an impact on clinical care.